Simon Johnson

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population
    Imran Haq
    School of Molecular Medical Sciences, Institute of Genetics, Queen s Medical Centre, University of Nottingham, UK
    BMC Med Genet 11:7. 2010
  2. ncbi Clinical experience of lymphangioleiomyomatosis in the UK
    S R Johnson
    Division of Respiratory Medicine, University of Nottingham, City Hospital, Nottingham NG5 1PB, UK
    Thorax 55:1052-7. 2000
  3. ncbi The ERS guidelines for LAM: trying a rationale approach to a rare disease
    Simon R Johnson
    Division of Therapeutics and Molecular Medicine and Nottingham NIHR Respiratory Biomedical Research Unit, Nottingham University Hospital NHS Trust, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom
    Respir Med 104:S33-41. 2010
  4. ncbi Management of rare diseases in respiratory medicine
    Simon R Johnson
    University Hospital, Queens Medical Centre, Nottingham
    Clin Med 7:447-8. 2007
  5. ncbi Lymphangioleiomyomatosis
    S R Johnson
    Division of Therapeutics and Molecular Medicine, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK
    Eur Respir J 27:1056-65. 2006
  6. ncbi Chronic Respiratory Diseases. Rare lung diseases. Introduction
    Simon Johnson
    Division of Therapeutics and Molecular Medicine, D Floor, South Block, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK
    Chron Respir Dis 2:73. 2005
  7. ncbi Survival and disease progression in UK patients with lymphangioleiomyomatosis
    S R Johnson
    Division of Therapeutics and Molecular Medicine, Queens Medical Centre, University of Nottingham, Nottingham, UK
    Thorax 59:800-3. 2004
  8. ncbi An assay to evaluate the long term effects of inflammatory mediators on airway smooth muscle: evidence that TNF(alpha)up-regulates 5-HT(2A) mediated contraction
    Simon R Johnson
    Division of Therapeutics, University Hospital, Nottingham NG7 2UH, UK
    Br J Pharmacol 137:943-4. 2002
  9. ncbi The TSC-2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma
    S R Johnson
    Division of Therapeutics, University of Nottingham, UK
    Histopathology 40:458-63. 2002
  10. ncbi Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells
    A M Freyer
    Division of Therapeutics and Institute of Cell Signalling, University Hospital, Nottingham, United Kingdom
    Am J Respir Cell Mol Biol 25:569-76. 2001

Collaborators

  • Anne E Tattersfield
  • A M Freyer
  • Ian P Hall
  • A Knox
  • Francis McCormack
  • Marsha M Cohen
  • Stacey M Pollock-Barziv
  • Imran Haq
  • M E Roberts
  • E C Harknett
  • Noor Kalsheker
  • D Mark Davies
  • Debbie Clements
  • Shona R Elshaw
  • N J Burrows
  • C I Whale
  • W Y C Chang
  • L Magowan
  • H Telford
  • S Geiling
  • S Byrnes
  • J Johnson
  • B Gray
  • R B Hubbard
  • Gillian E Lowrey
  • R Lazor
  • Kevin Morgan
  • Jan Stolk
  • Leslie Daly
  • William MacNee
  • Sally Chappell
  • Pieter S Hiemstra
  • Simonetta Monti
  • Seamas C Donnelly
  • Josep Roca
  • Roberto Rabinovich
  • Tamar Guetta-Baranes
  • Massimo Miniati
  • Clare M O'Connor
  • Juzer Lotya
  • Vera Keatings
  • Ann B Millar
  • Julian R Sampson
  • Jane A Cox
  • Frances Elmslie
  • Petrus J de Vries
  • Anand Saggar
  • Tim Doyle
  • J Chris Kingswood
  • Deborah L McCartney
  • R John Mayer
  • Susan A Watson
  • Neil Henderson
  • David J Buttle
  • S A Lewis
  • K G Phillips
  • S A Newton

Detail Information

Publications19

  1. ncbi Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population
    Imran Haq
    School of Molecular Medical Sciences, Institute of Genetics, Queen s Medical Centre, University of Nottingham, UK
    BMC Med Genet 11:7. 2010
    ..Previous genetic studies of MMPs in COPD have had inadequate coverage of the genes, and have reported conflicting associations of both single nucleotide polymorphisms (SNPs) and SNP haplotypes, plausibly due to under-powered studies...
  2. ncbi Clinical experience of lymphangioleiomyomatosis in the UK
    S R Johnson
    Division of Respiratory Medicine, University of Nottingham, City Hospital, Nottingham NG5 1PB, UK
    Thorax 55:1052-7. 2000
    ..This study provides data on the natural history of lymphangioleiomyomatosis in the UK and compares this with experience from other centres...
  3. ncbi The ERS guidelines for LAM: trying a rationale approach to a rare disease
    Simon R Johnson
    Division of Therapeutics and Molecular Medicine and Nottingham NIHR Respiratory Biomedical Research Unit, Nottingham University Hospital NHS Trust, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom
    Respir Med 104:S33-41. 2010
    ..It is hoped that these guidelines will result in standardisation of diagnostic criteria and patient management which will further improve clinical care and facilitate research and clinical trials...
  4. ncbi Management of rare diseases in respiratory medicine
    Simon R Johnson
    University Hospital, Queens Medical Centre, Nottingham
    Clin Med 7:447-8. 2007
  5. ncbi Lymphangioleiomyomatosis
    S R Johnson
    Division of Therapeutics and Molecular Medicine, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK
    Eur Respir J 27:1056-65. 2006
    ..Trials of rapamycin in lymphangioleiomyomatosis are currently underway and offer hope of evidence-based treatment for the disease...
  6. ncbi Chronic Respiratory Diseases. Rare lung diseases. Introduction
    Simon Johnson
    Division of Therapeutics and Molecular Medicine, D Floor, South Block, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK
    Chron Respir Dis 2:73. 2005
  7. ncbi Survival and disease progression in UK patients with lymphangioleiomyomatosis
    S R Johnson
    Division of Therapeutics and Molecular Medicine, Queens Medical Centre, University of Nottingham, Nottingham, UK
    Thorax 59:800-3. 2004
    ..In order to provide data for patients and for planning intervention studies, we have looked at the time course of LAM using a national cohort...
  8. ncbi An assay to evaluate the long term effects of inflammatory mediators on airway smooth muscle: evidence that TNF(alpha)up-regulates 5-HT(2A) mediated contraction
    Simon R Johnson
    Division of Therapeutics, University Hospital, Nottingham NG7 2UH, UK
    Br J Pharmacol 137:943-4. 2002
  9. ncbi The TSC-2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma
    S R Johnson
    Division of Therapeutics, University of Nottingham, UK
    Histopathology 40:458-63. 2002
    ..We used immunohistochemistry to test the hypothesis that uncontrolled cellular proliferation in lymphangioleiomyomatosis is the result of reduced tuberin protein expression...
  10. ncbi Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells
    A M Freyer
    Division of Therapeutics and Institute of Cell Signalling, University Hospital, Nottingham, United Kingdom
    Am J Respir Cell Mol Biol 25:569-76. 2001
    ....
  11. ncbi Lymphangioleiomyomatosis: a case-control study of perinatal and early life events
    C I Whale
    Division of Respiratory Medicine, City Hospital, Nottingham, UK
    Thorax 58:979-82. 2003
    ..Being more likely to be an only child and having an increased family history of uterine fibroids may, if confirmed, indicate some differences in reproductive function within the families of affected individuals...
  12. ncbi Use of variability in national and regional data to estimate the prevalence of lymphangioleiomyomatosis
    E C Harknett
    Division of Therapeutics and Molecular Medicine and Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, UK
    QJM 104:971-9. 2011
    ..As with all rare diseases, obtaining reliable epidemiological data is difficult and requires innovative approaches...
  13. ncbi Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD
    Imran Haq
    Division of Therapeutics and Molecular Medicine and NIHR Respiratory Biomedical Research Unit, Queens Medical Centre, University of Nottingham, D Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Thorax 66:970-6. 2011
    ..It has previously been shown that individuals homozygous for the A/A allele of rs652438 in MMP-12 are over-represented among patients with severe COPD (n=1517). A study was undertaken to examine the functional basis of these findings...
  14. ncbi Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production
    M E Roberts
    Division of Therapeutics and Molecular Medicine, Respiratory Biomedical Research Unit, University of Nottingham, D Floor South Block, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Eur Respir J 37:1482-93. 2011
    ..These data suggest that ECM signalling via DDR1 regulates aspects of bronchial epithelial repair, integrity and MMP expression in the airways...
  15. ncbi Pulmonary artery aneurysm and tuberous sclerosis
    N J Burrows
    Queens Medical Centre, University Hospital, Nottingham, UK
    Thorax 59:86. 2004
  16. ncbi Subcellular distribution of the TSC2 gene product tuberin in human airway smooth muscle cells is driven by multiple localization sequences and is cell-cycle dependent
    Debbie Clements
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Am J Physiol Lung Cell Mol Physiol 292:L258-66. 2007
    ..As tuberin has potential roles in proliferation, migration, and cell phenotype, it therefore warrants further investigation in diseases categorized by abnormalities in airway smooth muscle...
  17. ncbi Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis
    D Mark Davies
    N Engl J Med 358:200-3. 2008
  18. ncbi Air travel in women with lymphangioleiomyomatosis
    Stacey Pollock-Barziv
    Women s College Research Institute, Women s College Hospital, Toronto, Ontario, Canada
    Thorax 62:176-80. 2007
    ..A questionnaire-based evaluation of air travel in patients with LAM was conducted to determine experiences aboard commercial aircraft...
  19. ncbi Matrix metalloproteinase expression and activity in human airway smooth muscle cells
    Shona R Elshaw
    Division of Therapeutics and Molecular Medicine, University of Nottingham, University Hospital, Queens Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 142:1318-24. 2004
    ..Unstimulated cells secrete excess TIMP 1 and 2, preventing proteolytic activity. MMP-2 can be activated by thrombin which may contribute to airway remodelling...