Robin Irvine

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Mobility of proteins associated with the plasma membrane by interaction with inositol lipids
    David Brough
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Cell Sci 118:3019-25. 2005
  2. ncbi Back in the water: the return of the inositol phosphates
    R F Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK
    Nat Rev Mol Cell Biol 2:327-38. 2001
  3. ncbi 20 years of Ins(1,4,5)P3, and 40 years before
    Robin F Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK
    Nat Rev Mol Cell Biol 4:586-90. 2003
  4. ncbi The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants
    Maria-Luisa Giudici
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    FEBS Lett 580:6933-7. 2006
  5. ncbi Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation
    Jonathan P Richardson
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Cell Signal 19:1309-14. 2007
  6. ncbi Phosphatidylinositol 4-phosphate 5-kinase I?_v6, a new splice variant found in rodents and humans
    Yang Xia
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK
    Biochem Biophys Res Commun 411:416-20. 2011
  7. ncbi Cell signaling. The art of the soluble
    Robin Irvine
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 316:845-6. 2007
  8. ncbi The regulation and function of inositol 1,4,5-trisphosphate 3-kinases
    Robin F Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK
    Adv Enzyme Regul 46:314-23. 2006
  9. ncbi Nuclear inositide signalling -- expansion, structures and clarification
    Robin F Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK
    Biochim Biophys Acta 1761:505-8. 2006
  10. ncbi Inositol phospholipids: translocation, translocation, translocation
    R Irvine
    Department of Pharmacology University of Cambridge Tennis Court Road, Cambridge CB2 1QJ, UK
    Curr Biol 8:R557-9. 1998

Collaborators

Detail Information

Publications37

  1. ncbi Mobility of proteins associated with the plasma membrane by interaction with inositol lipids
    David Brough
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Cell Sci 118:3019-25. 2005
    ..Moreover, the mobility of GAP1(IP4BP) is not detectably altered by the generation of either of its two potential regulators, Ins(1,3,4,5)P(4) or PtdIns(3,4,5)P(3)...
  2. ncbi Back in the water: the return of the inositol phosphates
    R F Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK
    Nat Rev Mol Cell Biol 2:327-38. 2001
    ..Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling...
  3. ncbi 20 years of Ins(1,4,5)P3, and 40 years before
    Robin F Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK
    Nat Rev Mol Cell Biol 4:586-90. 2003
    ..The background to this discovery is a complex story that goes back more than 50 years and involves a large cast of characters, both chemical and human...
  4. ncbi The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants
    Maria-Luisa Giudici
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    FEBS Lett 580:6933-7. 2006
    ..Moreover, the markedly different localisation and mobility of active versus inactive PIPkin Igamma93 provide insights into the factors that dictate cellular targeting of Type Igamma PIPkins...
  5. ncbi Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation
    Jonathan P Richardson
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Cell Signal 19:1309-14. 2007
    ..Genomic tagging of endogenous proteins in DT40 cells is a technique that offers unique advantages in studying endogenous signalling proteins...
  6. ncbi Phosphatidylinositol 4-phosphate 5-kinase I?_v6, a new splice variant found in rodents and humans
    Yang Xia
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK
    Biochem Biophys Res Commun 411:416-20. 2011
    ....
  7. ncbi Cell signaling. The art of the soluble
    Robin Irvine
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 316:845-6. 2007
  8. ncbi The regulation and function of inositol 1,4,5-trisphosphate 3-kinases
    Robin F Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK
    Adv Enzyme Regul 46:314-23. 2006
  9. ncbi Nuclear inositide signalling -- expansion, structures and clarification
    Robin F Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK
    Biochim Biophys Acta 1761:505-8. 2006
    ..Here, a few key issues with regard to nuclear inositide signalling are briefly addressed...
  10. ncbi Inositol phospholipids: translocation, translocation, translocation
    R Irvine
    Department of Pharmacology University of Cambridge Tennis Court Road, Cambridge CB2 1QJ, UK
    Curr Biol 8:R557-9. 1998
    ....
  11. ncbi Inositide evolution - towards turtle domination?
    Robin F Irvine
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Physiol 566:295-300. 2005
    ..This review will focus on two specific aspects of this diversity: the evolution of the polyphosphoinositides, and the synthesis and functions of the higher inositol phosphates...
  12. ncbi Nuclear lipid signalling
    Robin F Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK
    Nat Rev Mol Cell Biol 4:349-60. 2003
    ..However, exactly as has been discovered in the cytoplasm, this is just part of a complex picture that involves many other lipids and functions...
  13. ncbi Nuclear lipid signaling
    R Irvine
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Sci STKE 2000:re1. 2000
    ....
  14. ncbi Manganese-stimulated phosphatidylinositol headgroup exchange in rat liver microsomes
    R F Irvine
    Department of Pharmacology, University of Cambridge, UK
    Biochim Biophys Acta 1393:292-8. 1998
    ....
  15. ncbi Inositol 1,3,4,5-tetrakisphosphate as a second messenger--a special role in neurones?
    R F Irvine
    Department of Pharmacology, University of Cambridge, UK
    Chem Phys Lipids 98:49-57. 1999
    ..In this review we discuss the possible relevance of these high expression levels to the complex way in which neurones control Ca2+ and use it as a second messenger...
  16. ncbi Inositol phosphates: Does IP(4) run a protection racket?
    R Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK
    Curr Biol 11:R172-4. 2001
    ..Recent findings about a hitherto unsuspected action of the IP(3) 3-kinase product, IP(4), suggest that the evolution of IP(3) 3-kinase may have even more far-reaching consequences than we thought...
  17. ncbi Nuclear lipid signaling
    Robin F Irvine
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1QJ, UK
    Sci STKE 2002:re13. 2002
    ....
  18. ncbi Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain
    Jonathan H Clarke
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD United Kingdom
    J Comp Neurol 517:296-312. 2009
    ..Overall, our data suggest that PIP4Kgamma may have a role in neuron function, specifically in the regulation of vesicular transport, in specific regions of the developed brain...
  19. ncbi Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron
    Jonathan H Clarke
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Am J Physiol Renal Physiol 295:F1422-30. 2008
    ..Overall our data suggest that PIP4Kgamma may have a function in the regulation of vesicular transport in specialized kidney epithelial cells...
  20. ncbi Reversible binding and rapid diffusion of proteins in complex with inositol lipids serves to coordinate free movement with spatial information
    Gerald R V Hammond
    Department of Pharmacology, University of Cambridge, Cambridge, England, UK
    J Cell Biol 184:297-308. 2009
    ....
  21. ncbi Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2)
    Gerald R V Hammond
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Biochem J 422:23-35. 2009
    ..In addition, we present evidence that the majority of PtdIns4P resides in the plasma membrane, where it is metabolically distinct from the steady-state plasma membrane pool of PtdIns(4,5)P(2)...
  22. ncbi Type IIalpha phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms
    Katherine A Hinchliffe
    University of Cambridge, Department of Pharmacology, Tennis Court Road, Cambridge, CB2 1PD, U K
    Biochem J 363:563-70. 2002
    ..This change in subcellular localization could result in improved access of the type IIalpha PIPkin to its lipid substrates...
  23. ncbi Regulation of type II PIP kinase by PKD phosphorylation
    Katherine A Hinchliffe
    Faculty of Life Sciences, The University of Manchester, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, United Kingdom
    Cell Signal 18:1906-13. 2006
    ..We conclude that the type II PIP kinases are physiological targets for PKD phosphorylation, and that this modification is likely to regulate inositol lipid turnover by inhibition of these lipid kinases...
  24. ncbi Regulation of inositol 1,4,5-trisphosphate 3-kinases by calcium and localization in cells
    Samantha M Lloyd-Burton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Biol Chem 282:9526-35. 2007
    ....
  25. ncbi Inositol lipids: to PHix or not to PHix?
    Robin Irvine
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK
    Curr Biol 14:R308-10. 2004
  26. ncbi A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma
    Maria Luisa Giudici
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Biochem J 379:489-96. 2004
    ....
  27. ncbi Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines
    Hilary F Roberts
    Department of Pharmacology, University of Cambridge, UK
    FEBS Lett 579:2868-72. 2005
    ....
  28. ncbi The structural integrity of the endoplasmic reticulum, and its possible regulation by inositol 1,3,4,5-tetrakisphosphate
    David Brough
    Department of Pharmacology, Cambridge, UK
    Cell Calcium 38:153-9. 2005
    ..However, we were subsequently unable to detect by FRAP any significant effect of Ins(1,3,4,5)P(4) on ER integrity...
  29. ncbi Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIalpha and IIbeta and a partial nuclear localization of the IIalpha isoform
    Minchuan Wang
    Department of Pharmacology, Tennis Court Road, Cambridge, U K
    Biochem J 430:215-21. 2010
    ..Overall the results suggest a function of PtdIns5P 4-kinase IIbeta may be to target the more active IIalpha isoform into the nucleus...
  30. ncbi Do mammals make all their own inositol hexakisphosphate?
    Andrew J Letcher
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB21PD, UK
    Biochem J 416:263-70. 2008
    ..Therefore claims that administrating InsP6 in the diet or applying it topically can produce health benefits by increasing extracellular InsP6 levels may require reassessment...
  31. ncbi A femtomole-sensitivity mass assay for inositol hexakisphosphate
    Andrew J Letcher
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Methods Mol Biol 645:61-71. 2010
    ..But the assay is unambiguous and is capable of quantifying accurately as little as 10 fmol of InsP(6) in a cell extract...
  32. ncbi Calcium-triggered exit of F-actin and IP(3) 3-kinase A from dendritic spines is rapid and reversible
    Michael J Schell
    Department of Pharmacology, University of Cambridge CB2 1PD, UK
    Eur J Neurosci 24:2491-503. 2006
    ..This process contributes to changes in spine F-actin shape and content during synaptic activity, and might also regulate spine IP3 signals...
  33. ncbi Solution behaviour of myo-inositol hexakisphosphate in the presence of multivalent cations. Prediction of a neutral pentamagnesium species under cytosolic/nuclear conditions
    Julia Torres
    , Departamento Estrella Campos, , , CC 1157, Montevideo, Uruguay
    J Inorg Biochem 99:828-40. 2005
    ..In vitro, InsP6 also forms high affinity 1:1 complexes with Fe(III) and Al(III). However, our data predict that in the biological context of excess free Mg(II), neither Fe(III) nor Fe(II) are complexed by InsP6...
  34. ncbi Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase
    Beatriz Gonzalez
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Mol Cell 15:689-701. 2004
    ..This lobe embraces all of the phosphates of Ins(1,4,5)P3 in a positively charged pocket, explaining the enzyme's substrate specificity and its inability to phosphorylate PtdIns(4,5)P2, the membrane-resident analog of Ins(1,4,5)P3...
  35. ncbi Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b
    Dale J Powner
    CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    J Cell Sci 118:2975-86. 2005
    ....
  36. ncbi Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores
    Alan P Dawson
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem J 370:621-9. 2003
    ....