Mark M Iles

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi What can genome-wide association studies tell us about the genetics of common disease?
    Mark M Iles
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
    PLoS Genet 4:e33. 2008
  2. ncbi Quantification and correction of bias in tagging SNPs caused by insufficient sample size and marker density by means of haplotype-dropping
    Mark M Iles
    Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
    Genet Epidemiol 32:20-8. 2008
  3. ncbi The impact of incomplete linkage disequilibrium and genetic model choice on the analysis and interpretation of genome-wide association studies
    Mark M Iles
    Section of Epidemiology and Biostatistics, Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Beckett Street, Leeds, LS9 7TF, UK
    Ann Hum Genet 74:375-9. 2010
  4. ncbi Genome-wide association study identifies three new melanoma susceptibility loci
    Jennifer H Barrett
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James s University Hospital, Leeds, UK
    Nat Genet 43:1108-13. 2011
  5. ncbi Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett Street, Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2043-54. 2010
  6. ncbi Analysis of variants in DNA damage signalling genes in bladder cancer
    Ananya Choudhury
    Cancer Research UK Clinical Centre, Section of Oncology, Leeds Institute of Molecular Medicine, Leeds, LS9 7TF, UK
    BMC Med Genet 9:69. 2008
  7. ncbi Genome-wide association study identifies three loci associated with melanoma risk
    D Timothy Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Nat Genet 41:920-5. 2009
  8. ncbi Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression
    Nils Schoof
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
    PLoS ONE 6:e29451. 2011
  9. ncbi Genome-wide association studies
    Mark M Iles
    Section of Epidemiology and Biostatistics, Leeds Institute for Molecular Medicine, University of Leeds, Leeds, UK
    Methods Mol Biol 713:89-103. 2011
  10. ncbi Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008

Detail Information

Publications22

  1. ncbi What can genome-wide association studies tell us about the genetics of common disease?
    Mark M Iles
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
    PLoS Genet 4:e33. 2008
    ..Thus, although the truth of the common disease / common variant hypothesis remains undecided, recent successes suggest that there are many more common genetic disease-associated variants, requiring larger studies to be identified...
  2. ncbi Quantification and correction of bias in tagging SNPs caused by insufficient sample size and marker density by means of haplotype-dropping
    Mark M Iles
    Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
    Genet Epidemiol 32:20-8. 2008
    ..This has obvious ramifications for tSNP selection both in candidate regions and using HapMap or SNP chips for genomewide studies...
  3. ncbi The impact of incomplete linkage disequilibrium and genetic model choice on the analysis and interpretation of genome-wide association studies
    Mark M Iles
    Section of Epidemiology and Biostatistics, Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Beckett Street, Leeds, LS9 7TF, UK
    Ann Hum Genet 74:375-9. 2010
    ..This may lead to problems in interpreting risk estimates...
  4. ncbi Genome-wide association study identifies three new melanoma susceptibility loci
    Jennifer H Barrett
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James s University Hospital, Leeds, UK
    Nat Genet 43:1108-13. 2011
    ..6 × 10(-7) under a fixed-effects model and P = 1.2 × 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series...
  5. ncbi Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett Street, Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2043-54. 2010
    ..Increased number of melanocytic nevi is a potent melanoma risk factor. We have carried out a large population-based case-control study to explore the environmental and genetic determinants of nevi and the relationship with melanoma risk...
  6. ncbi Analysis of variants in DNA damage signalling genes in bladder cancer
    Ananya Choudhury
    Cancer Research UK Clinical Centre, Section of Oncology, Leeds Institute of Molecular Medicine, Leeds, LS9 7TF, UK
    BMC Med Genet 9:69. 2008
    ..We hypothesized that SNPs in DSB signalling genes may modulate predisposition to bladder cancer and influence the effects of environmental exposures...
  7. ncbi Genome-wide association study identifies three loci associated with melanoma risk
    D Timothy Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Nat Genet 41:920-5. 2009
    ..Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk...
  8. ncbi Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression
    Nils Schoof
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
    PLoS ONE 6:e29451. 2011
    ..As one of the first attempts to replicate a pathway-level association, our results suggest that low power and heterogeneity may present challenges...
  9. ncbi Genome-wide association studies
    Mark M Iles
    Section of Epidemiology and Biostatistics, Leeds Institute for Molecular Medicine, University of Leeds, Leeds, UK
    Methods Mol Biol 713:89-103. 2011
    ..After some background and an introduction to GWA, studies are considered stage-by-stage with particular focus on quality control as this is by far the most time-consuming and complex issue related to GWA...
  10. ncbi Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  11. ncbi Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  12. ncbi Genomewide association analysis of coronary artery disease
    Nilesh J Samani
    University of Leicester, Leicester, United Kingdom
    N Engl J Med 357:443-53. 2007
    ..Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease...
  13. ncbi Recombination can evolve in large finite populations given selection on sufficient loci
    Mark M Iles
    Mathematical Modelling and Genetic Epidemiology, Division of Genomic Medicine, University of Sheffield, Sheffield S10 2JF, United Kingdom
    Genetics 165:2249-58. 2003
    ..Thus fixation of a particular haplotype is less likely to occur, increasing the advantage of recombination...
  14. ncbi Additional genetic susceptibility for rheumatoid arthritis telomeric of the DRB1 locus
    Rachael Kilding
    The University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Arthritis Rheum 50:763-9. 2004
    ..This is a genomic segment of high linkage disequilibrium containing a large number of poorly characterized immunomodulatory genes...
  15. ncbi Sequential genotyping within TDT families
    Mark M Iles
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Math Med Biol 21:115-27. 2004
    ..We discuss the practical application of such sequential genotyping and illustrate its potential using a real data set...
  16. ncbi Linkage and association. The transmission/disequilibrium test for QTLs
    Mark M Iles
    Division of Genomic Medicine, University of Sheffield, UK
    Methods Mol Biol 195:101-38. 2002
  17. ncbi Single-point haplotype scores telomeric to human leukocyte antigen-C give a high susceptibility major histocompatibility complex haplotype for psoriasis in a Caucasian population
    Nick Lench
    Oxagen Limited, Abingdon, Oxon, UK
    J Invest Dermatol 124:545-52. 2005
    ..53; p=0.0051). Our results give scores as high as the highest single-point scores suggesting that it is unlikely to be able to discriminate the origin of the association on this analysis on strength of association...
  18. ncbi Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk
    Kristjana Einarsdóttir
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    PLoS Med 3:e168. 2006
    ..In this study, we aimed to assess the importance of common CHEK2 variants on population risk for breast cancer by capturing the majority of diversity in the gene using haplotype tagging single nucleotide polymorphisms (tagSNPs)...
  19. ncbi Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  20. ncbi Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans population
    Gurdeep S Sagoo
    Biomedical Genetics Project, Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    J Invest Dermatol 122:1401-5. 2004
    ..To overcome this problem, we suggest that future studies condition on the effect of the PSORS1 locus...
  21. ncbi Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  22. ncbi The effect of SNP marker density on the efficacy of haplotype tagging SNPs--a warning
    Mark M Iles
    University of Sheffield, UK
    Ann Hum Genet 69:209-15. 2005
    ..Such findings are important both for individual studies utilising htSNPs to reduce costs, and for projects such as HapMap which try to characterise human genomic variation using htSNPs...