Xu Huang

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines
    Weiwei Fan
    Division of Genetics, Department of Pediatrics, Robert R Sprague Hall 314, University of California Irvine, Irvine, CA 92697, USA
    Cancer Res 64:5132-9. 2004
  2. ncbi Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
    Xu Huang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 412:211-21. 2008
  3. ncbi Identification of Protor as a novel Rictor-binding component of mTOR complex-2
    Laura R Pearce
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 405:513-22. 2007
  4. ncbi The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)
    Xu Huang
    Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC 29208, U S A
    Biochem J 366:175-86. 2002
  5. ncbi The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity
    Vishal Gupta
    Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC 29208, USA
    Virology 315:283-91. 2003
  6. ncbi TBX5, a gene mutated in Holt-Oram syndrome, is regulated through a GC box and T-box binding elements (TBEs)
    Guifeng Sun
    Department of Pediatrics, Division of Human Genetics and Metabolism, University of California, Irvine, California 92697, USA
    J Cell Biochem 92:189-99. 2004
  7. ncbi CcbP, a calcium-binding protein from Anabaena sp. PCC 7120, provides evidence that calcium ions regulate heterocyst differentiation
    Yinhong Zhao
    State Key Laboratory of Protein and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 102:5744-8. 2005
  8. ncbi Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation
    Annette Gärtner
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK
    J Cell Sci 119:3927-34. 2006
  9. ncbi Construction of a high sensitive Escherichia coli alkaline phosphatase reporter system for screening affinity peptides
    Xu Huang
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    J Biochem Biophys Methods 70:435-9. 2007

Collaborators

Detail Information

Publications9

  1. ncbi TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines
    Weiwei Fan
    Division of Genetics, Department of Pediatrics, Robert R Sprague Hall 314, University of California Irvine, Irvine, CA 92697, USA
    Cancer Res 64:5132-9. 2004
    ..A subset of human breast cancer cell lines overexpresses TBX3. Our results indicate that TBX3 and TBX3 + 2a are functionally distinctive in inhibition of senescence of MEF cells and may play a role in breast cancer...
  2. ncbi Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
    Xu Huang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 412:211-21. 2008
    ....
  3. ncbi Identification of Protor as a novel Rictor-binding component of mTOR complex-2
    Laura R Pearce
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 405:513-22. 2007
    ..Protor-1 is a novel Rictor-binding subunit of mTORC2, but further work is required to establish its role...
  4. ncbi The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)
    Xu Huang
    Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC 29208, U S A
    Biochem J 366:175-86. 2002
    ..In addition, domain 3 and eukaryotic initiation factor 2alpha both interact with PKR through the same region within PKR, which we have mapped to lie between amino acid residues 318 and 551...
  5. ncbi The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity
    Vishal Gupta
    Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC 29208, USA
    Virology 315:283-91. 2003
    ..Domain swap experiments between PACT and TRBP indicated that the inhibitory effects of TRBP on PKR activity are mediated through its carboxy-terminal residues, which contain TRBP's third dsRNA-binding motif...
  6. ncbi TBX5, a gene mutated in Holt-Oram syndrome, is regulated through a GC box and T-box binding elements (TBEs)
    Guifeng Sun
    Department of Pediatrics, Division of Human Genetics and Metabolism, University of California, Irvine, California 92697, USA
    J Cell Biochem 92:189-99. 2004
    ..We conclude that the GC box, T-box-like binding elements, and NKX2.5 binding site play important roles in the regulation of TBX5 expression, and that TBX5 is likely to be autoregulated as part of the mechanism of its transcription...
  7. ncbi CcbP, a calcium-binding protein from Anabaena sp. PCC 7120, provides evidence that calcium ions regulate heterocyst differentiation
    Yinhong Zhao
    State Key Laboratory of Protein and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 102:5744-8. 2005
    ..These results suggest that Ca(2+) ions play very important roles in hetR induction and heterocyst differentiation...
  8. ncbi Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation
    Annette Gärtner
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK
    J Cell Sci 119:3927-34. 2006
    ..We conclude that GSK-3beta inhibition promotes the development of neuronal polarity, but that this is not mediated by Akt/PKB-dependent phosphorylation...
  9. ncbi Construction of a high sensitive Escherichia coli alkaline phosphatase reporter system for screening affinity peptides
    Xu Huang
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    J Biochem Biophys Methods 70:435-9. 2007
    ..This method may be used for effective high-throughput screening of high affinity peptide from the peptide pool...