Research Topics
| K F HoffmannSummaryAffiliation: University of Cambridge Country: UK Publications
| Collaborators
|
Detail Information
Publications
Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profilingKarl F Hoffmann
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Genome Biol 3:RESEARCH0041. 2002..We have used cDNA microarray technology to initiate genome-wide gene-expression studies of sex and sexual development in mature Schistosoma mansoni parasites...- An oligonucleotide microarray for transcriptome analysis of Schistosoma mansoni and its application/use to investigate gender-associated gene expressionJennifer M Fitzpatrick
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Mol Biochem Parasitol 141:1-13. 2005..These data demonstrate the power of this new resource to facilitate a greater understanding into the biological complexities of schistosome development and maturation useful for identifying novel intervention strategies... - Changes in IgE- and antigen-dependent histamine-release in peripheral blood of Schistosoma mansoni-infected Ugandan fishermen after treatment with praziquantelMohamed Z Satti
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
BMC Immunol 5:6. 2004..mansoni infection, before and 1-day and 21-days after PZQ treatment... - An historical and genomic view of schistosome conjugal biology with emphasis on sex-specific gene expressionK F Hoffmann
University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK
Parasitology 128:S11-22. 2004..Following this discussion is a current overview of some modern day genomic approaches used to study schistosomes, which illustrates how major advances in the field of conjugal biology will be achieved... - Characterization of the Schistosoma transcriptome opens up the world of helminth genomicsKarl F Hoffmann
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Genome Biol 5:203. 2003..This new genomic information will have an enormous impact on all future investigations into the biology, pathogenesis and control of schistosomiasis... - The guanine protein coupled receptor rhodopsin is developmentally regulated in the free-living stages of Schistosoma mansoniK F Hoffmann
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike Bldg 7 Room 318, Bethesda, MD 20892, USA
Mol Biochem Parasitol 112:113-23. 2001..Identifying and characterizing new GPCRs may uncover hidden aspects of parasite biology useful towards the development of novel intervention strategies... - Integrating transcriptome, proteome and glycome analyses of Schistosoma biologyCornelis H Hokke
Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Trends Parasitol 23:165-74. 2007..In this article, we review these postgenomic investigations and contend that the generated datasets provide a plethora of novel drug, vaccine and immunomodulatory targets that might be useful for developing new antischistosome agents... - Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinasesJennifer M Fitzpatrick
Department of Pathology, University of Cambridge, Tennis Court Rd, CB2 1QP, UK
FASEB J 21:823-35. 2007.... - Factors affecting human IgE and IgG responses to allergen-like Schistosoma mansoni antigens: Molecular structure and patterns of in vivo exposureColin M Fitzsimmons
Department of Pathology, University of Cambridge, Cambridge, UK
Int Arch Allergy Immunol 142:40-50. 2007..Here we compare human IgE and IgG responses to other family members, Sm20.8 and Sm21.7, as well as to SmDLC1, relating these to antigen structure and expression in parasite life stages... - Dioecious Schistosoma mansoni express divergent gene repertoires regulated by pairingJennifer M Fitzpatrick
University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
Int J Parasitol 36:1081-9. 2006.... - Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantelClaus M Reimert
DBL, Institute for Health Research and Development, Jaegersborg Alle 1 D, 2720 Charlottenlund, Denmark
Clin Vaccine Immunol 13:584-93. 2006..Moreover, it is possible that infection intensity-dependent levels of plasma IL-10 may be involved in the prevention of treatment-induced anaphylactic reactions... - Schistosoma mansoni: DNA microarray gene expression profiling during the miracidium-to-mother sporocyst transformationJon J Vermeire
Department of Pathobiological Sciences, University of Wisconsin-Madison, 2115 Observatory Drive, Madison, WI 53706, USA
Mol Biochem Parasitol 147:39-47. 2006..mansoni larvae provides a starting point for expanding our understanding of the genes that may be involved in the establishment of parasitism and maintenance of infection in these important life cycle stages... - Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggsColin M Fitzsimmons
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Mol Biochem Parasitol 144:123-7. 2005 - Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathologyKarl F Hoffmann
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Adv Parasitol 52:265-307. 2002..Development of severe and non-overlapping immunopathological phenotypes will be discussed in the context of immune deviation and in the setting of chronic and/or hyper-polarised cytokine environments... - Gene expression studies using self-fabricated parasite cDNA microarraysKarl F Hoffmann
Department of Pathology, University of Cambridge, UK
Methods Mol Biol 270:219-36. 2004..Methods described herein were adapted for the study of schistosome sexual maturation and developmental biology but could be easily modified for the study of any additional parasitological system... - Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin EColin M Fitzsimmons
Department of Pathology, University of Cambridge, Cambridge, United Kingdom
Infect Immun 72:4023-30. 2004.... - Gender-associated gene expression in two related strains of Schistosoma japonicumJennifer M Fitzpatrick
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Mol Biochem Parasitol 136:191-209. 2004..japonicum gender-associated gene transcripts that may be considered targets for improved intervention strategies... - Human IgE response to the Schistosoma haematobium 22.6 kDa antigenC M Fitzsimmons
Department of Pathology, University of Cambridge, Cambridge, UK
Parasite Immunol 26:371-6. 2004..These results demonstrate that like related molecules in other species, Sh22.6 is a target for the human IgE response. The data also indicate that changes in the IgE response occur with age or with progressive exposure to key antigens... - Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene familyIain W Chalmers
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
BMC Genomics 9:89. 2008..Proteins containing this domain are implicated in diverse biological activities and may be important for chronic host/parasite interactions... - Gender-specific expression of complex-type N-glycans in schistosomesManfred Wuhrer
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Glycobiology 16:991-1006. 2006.... - P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptorThomas A Wynn
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6154, MSC 8003, Bethesda, MD 20892, USA
Hepatology 39:676-87. 2004..By suppressing IFN-gamma and up-regulating the decoy IL-13 receptor, P-selectin dramatically inhibits the pathologic tissue remodeling that results from chronic type 2 cytokine-mediated inflammation... - Glycomics-driven discoveries in schistosome researchCornelis H Hokke
Department of Parasitology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Exp Parasitol 117:275-83. 2007..Here we will present a concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles, and discuss implications and prospects of glycomics studies of schistosomes... - Schistosome genomics and beyond: news and viewsChristoph G Grevelding
Justus-Liebig-University Giessen, Institute for Parasitology, Rudolf-Buchheimstr. 2, 35392 Giessen, Germany
Exp Parasitol 117:223-4. 2007