S M Henson

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
    Sian M Henson
    Division of Infection and Immunity, University College London, London, UK
    Immunology 135:355-63. 2012
  2. ncbi Memory T-cell homeostasis and senescence during aging
    Sian M Henson
    Division of Infection and Immunity, Department of Immunology, University College London, 46 Cleveland Street, London, W1T 4JF, UK
    Adv Exp Med Biol 684:189-97. 2010
  3. ncbi KLRG1--more than a marker for T cell senescence
    Sian M Henson
    Division of Infection and Immunity, Department of Immunology, University College London, 46 Cleveland Street, London, UK
    Age (Dordr) 31:285-91. 2009
  4. ncbi An IL-7 fusion protein that shows increased thymopoietic ability
    Sian M Henson
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
    J Immunol 175:4112-8. 2005
  5. ncbi KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells
    Sian M Henson
    Department of Immunology, University College London, 46 Cleveland Street, London, United Kingdom
    Blood 113:6619-28. 2009
  6. ncbi The use of the inhibitory receptors for modulating the immune responses
    S M Henson
    Immunology, Division of Infection and Immunity, UCL, 46 Cleveland Street, London, W1T 4JF, UK
    Curr Pharm Des 14:2643-50. 2008
  7. ncbi Reversal of thymic atrophy
    Sian M Henson
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Exp Gerontol 39:673-8. 2004
  8. ncbi Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination
    Richard Aspinall
    Department of Immunology, Faculty of Medicine, Imperial College London, UK
    Rejuvenation Res 10:5-17. 2007
  9. ncbi Long-term effects of perinatal nutrition on T lymphocyte kinetics in young Gambian men
    Hala Ghattas
    Centre for Infection, St George s, University of London, London, United Kingdom
    Am J Clin Nutr 85:480-7. 2007
  10. ncbi Improved thymic function in exclusively breastfed infants is associated with higher interleukin 7 concentrations in their mothers' breast milk
    Pa T Ngom
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Am J Clin Nutr 80:722-8. 2004

Collaborators

  • R Aspinall
  • Arne N Akbar
  • Tracy Hussell
  • Diana L Wallace
  • Nesrina Imami
  • J Heeney
  • D C MacAllan
  • Pa T Ngom
  • Hala Ghattas
  • Andrew M Prentice
  • Dietmar Herndler-Brandstetter
  • Yan Zhang
  • Gareth Morgan
  • Juan A Solon
  • George E Griffin
  • Beatrix Grubeck-Loebenstein
  • Daniel P Cioca
  • Susanne Schwaiger
  • Gerald Pfister
  • Ellen Veel
  • Michael Keller
  • Christine Fehrer
  • Walther Parson
  • Diether Schönitzer
  • Giovanni Almanzar
  • Reinhard Wurzner
  • Günter Lepperdinger
  • Jeffrey Pido-Lopez
  • Andrew C Collinson

Detail Information

Publications12

  1. ncbi Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
    Sian M Henson
    Division of Infection and Immunity, University College London, London, UK
    Immunology 135:355-63. 2012
    ..These data collectively highlight that some, but not all, functional changes that arise during progressive T-cell differentiation and during ageing are maintained actively by inhibitory receptor signalling...
  2. ncbi Memory T-cell homeostasis and senescence during aging
    Sian M Henson
    Division of Infection and Immunity, Department of Immunology, University College London, 46 Cleveland Street, London, W1T 4JF, UK
    Adv Exp Med Biol 684:189-97. 2010
    ..We discuss here mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases...
  3. ncbi KLRG1--more than a marker for T cell senescence
    Sian M Henson
    Division of Infection and Immunity, Department of Immunology, University College London, 46 Cleveland Street, London, UK
    Age (Dordr) 31:285-91. 2009
    ..In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling...
  4. ncbi An IL-7 fusion protein that shows increased thymopoietic ability
    Sian M Henson
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
    J Immunol 175:4112-8. 2005
    ..This chimeric molecule offers a novel therapeutic strategy that may result in the production of an effective immunorestorative agent...
  5. ncbi KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells
    Sian M Henson
    Department of Immunology, University College London, 46 Cleveland Street, London, United Kingdom
    Blood 113:6619-28. 2009
    ....
  6. ncbi The use of the inhibitory receptors for modulating the immune responses
    S M Henson
    Immunology, Division of Infection and Immunity, UCL, 46 Cleveland Street, London, W1T 4JF, UK
    Curr Pharm Des 14:2643-50. 2008
    ..In this review, we examine the role of CTLA-4 and PD-1 in regulating immune response and discuss their therapeutic potential during aging...
  7. ncbi Reversal of thymic atrophy
    Sian M Henson
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Exp Gerontol 39:673-8. 2004
    ..In this review, we highlight the advances in molecular approaches used to evaluate recent thymic emigrants and assess the success of these strategies in determining whether IL-7 can lead to immune reconstitution...
  8. ncbi Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination
    Richard Aspinall
    Department of Immunology, Faculty of Medicine, Imperial College London, UK
    Rejuvenation Res 10:5-17. 2007
    ..Treatment of the elderly with IL-7 may provide an effective therapy to improve the immune system...
  9. ncbi Long-term effects of perinatal nutrition on T lymphocyte kinetics in young Gambian men
    Hala Ghattas
    Centre for Infection, St George s, University of London, London, United Kingdom
    Am J Clin Nutr 85:480-7. 2007
    ..In a rural Gambian setting, individuals born during periods of seasonal nutritional deprivation ("hungry seasons") are susceptible to mortality from infectious diseases in adult life...
  10. ncbi Improved thymic function in exclusively breastfed infants is associated with higher interleukin 7 concentrations in their mothers' breast milk
    Pa T Ngom
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Am J Clin Nutr 80:722-8. 2004
    ..CONCLUSION: These data show a plausible pathway linking external seasonal insults to mothers with thymic development in their infants, which suggests possible implications for long-term programming of immunity...
  11. ncbi My T's gone cold, I'm wondering why
    Richard Aspinall
    Department of Immunology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK
    Nat Immunol 4:203-5. 2003
  12. ncbi CD25-expressing CD8+ T cells are potent memory cells in old age
    Dietmar Herndler-Brandstetter
    Immunology Division, Institute for Biomedical Aging and Research, Austrian Academy of Sciences, Innsbruck, Austria
    J Immunol 175:1566-74. 2005
    ..Accumulation of these cells in elderly persons appears to be a prerequisite of intact immune responsiveness in the absence of naive T cells in old age...