Roger Harrison

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. ncbi Structure and function of xanthine oxidoreductase: where are we now?
    Roger Harrison
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    Free Radic Biol Med 33:774-97. 2002
  2. ncbi Role of xanthine oxidoreductase as an antimicrobial agent
    Hannah M Martin
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Infect Immun 72:4933-9. 2004
  3. ncbi Xanthine oxidoreductase is present in bile ducts of normal and cirrhotic liver
    Hannah M Martin
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Free Radic Biol Med 37:1214-23. 2004
  4. ncbi Molecular characterization of human xanthine oxidoreductase: the enzyme is grossly deficient in molybdenum and substantially deficient in iron-sulphur centres
    Benjamin L J Godber
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Biochem J 388:501-8. 2005
  5. ncbi Physiological roles of xanthine oxidoreductase
    Roger Harrison
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    Drug Metab Rev 36:363-75. 2004
  6. ncbi Antimicrobial properties of milk: dependence on presence of xanthine oxidase and nitrite
    John T Hancock
    Centre for Research in Biomedicine, University of the West of England, Bristol, United Kingdom
    Antimicrob Agents Chemother 46:3308-10. 2002
  7. ncbi Goats' milk xanthine oxidoreductase is grossly deficient in molybdenum
    Djebbar Atmani
    Laboratoire Biomathematiques, Biophysique, Biochimie et Scientometrie, Facultie des Sciences de la Nature et de la Vie, Universite de Bejaia 06000, Algeria
    J Dairy Res 71:7-13. 2004
  8. ncbi Physicochemical and kinetic properties of purified sheep's milk xanthine oxidoreductase
    Mustapha Benboubetra
    Laboratory of Applied Biochemistry, Department of Biology, Faculty of Sciences, University Ferhat Abbas of Setif, Algeria
    J Dairy Sci 87:1580-4. 2004
  9. ncbi Xanthine oxidoreductase is central to the evolution and function of the innate immune system
    Claudia Vorbach
    Ontario Cancer Institute, Princess Margaret Hospital/University Health Network, Toronto, Ontario, M5G 2C1, Canada
    Trends Immunol 24:512-7. 2003

Collaborators

Detail Information

Publications9

  1. ncbi Structure and function of xanthine oxidoreductase: where are we now?
    Roger Harrison
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    Free Radic Biol Med 33:774-97. 2002
    ..The details of these recent findings, their pathophysiological implications, and the requirements for future research are addressed in this review...
  2. ncbi Role of xanthine oxidoreductase as an antimicrobial agent
    Hannah M Martin
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Infect Immun 72:4933-9. 2004
  3. ncbi Xanthine oxidoreductase is present in bile ducts of normal and cirrhotic liver
    Hannah M Martin
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Free Radic Biol Med 37:1214-23. 2004
    ..We conclude that XOR is expressed primarily in hepatocytes, but is also present in bile duct epithelial cells and is secreted into bile. Its role in bile is unknown but it may be involved in innate immunity of the bowel muscosa...
  4. ncbi Molecular characterization of human xanthine oxidoreductase: the enzyme is grossly deficient in molybdenum and substantially deficient in iron-sulphur centres
    Benjamin L J Godber
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Biochem J 388:501-8. 2005
    ..g. in secretion) equal in importance to its catalytic function as an enzyme...
  5. ncbi Physiological roles of xanthine oxidoreductase
    Roger Harrison
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    Drug Metab Rev 36:363-75. 2004
    ..The enzyme purified from breast milk shows very low enzymatic activity, and it is suggested that human XOR has evolved so as to be regulated by an exceptional range of pre- and posttranslational mechanisms...
  6. ncbi Antimicrobial properties of milk: dependence on presence of xanthine oxidase and nitrite
    John T Hancock
    Centre for Research in Biomedicine, University of the West of England, Bristol, United Kingdom
    Antimicrob Agents Chemother 46:3308-10. 2002
    ..Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrite, implying that XO-generated nitric oxide functions as an antibacterial agent...
  7. ncbi Goats' milk xanthine oxidoreductase is grossly deficient in molybdenum
    Djebbar Atmani
    Laboratoire Biomathematiques, Biophysique, Biochimie et Scientometrie, Facultie des Sciences de la Nature et de la Vie, Universite de Bejaia 06000, Algeria
    J Dairy Res 71:7-13. 2004
    ..A parallel purification of human milk XOR showed 0.03 atoms Mo per subunit. The possible physiological significance of the low molybdenum content of the caprine milk enzyme and of its correspondingly low enzymic activity is discussed...
  8. ncbi Physicochemical and kinetic properties of purified sheep's milk xanthine oxidoreductase
    Mustapha Benboubetra
    Laboratory of Applied Biochemistry, Department of Biology, Faculty of Sciences, University Ferhat Abbas of Setif, Algeria
    J Dairy Sci 87:1580-4. 2004
    ..The presence of desulpho-enzyme in sheep's milk XOR was demonstrated by resulfuration experiments, whereby xanthine oxidase activity was increased by approximately 75%...
  9. ncbi Xanthine oxidoreductase is central to the evolution and function of the innate immune system
    Claudia Vorbach
    Ontario Cancer Institute, Princess Margaret Hospital/University Health Network, Toronto, Ontario, M5G 2C1, Canada
    Trends Immunol 24:512-7. 2003