Research Topics
Species | Lynda K HarrisSummaryAffiliation: University of Manchester Country: UK Publications
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Detail Information
Publications
Plasma from women with preeclampsia inhibits trophoblast invasionL K Harris
Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester, M13 9WL, United Kingdom
Reprod Sci 16:1082-90. 2009..The authors conclude that plasma from women with preeclampsia contains multiple factors that inhibit invasion. These factors do not specifically target invading cells, but instead may reduce the number of cells available to invade...- IFPA Gabor Than Award lecture: Transformation of the spiral arteries in human pregnancy: key events in the remodelling timelineL K Harris
Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
Placenta 32:S154-8. 2011..Parallels with remodelling events occurring in other vascular beds will also be drawn... - Trophoblast- and vascular smooth muscle cell-derived MMP-12 mediates elastolysis during uterine spiral artery remodelingLynda K Harris
Maternal and Fetal Health Research Centre, University of Manchester, Manchester Academic Health Science Centre, St Mary s Hospital, Manchester, United Kingdom
Am J Pathol 177:2103-15. 2010.... - Review: Trophoblast-vascular cell interactions in early pregnancy: how to remodel a vesselL K Harris
Maternal and Fetal Health Research Group, University of Manchester, Research 5th floor, St Mary s Hospital, Oxford Road, Manchester, M13 9WL, UK
Placenta 31:S93-8. 2010.... - Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancySamantha D Smith
Maternal and Fetal Health Research Group, Research Floor, St Mary s Hospital, Manchester, UK
Am J Pathol 174:1959-71. 2009..We thus confirm that vascular remodeling occurs in distinct trophoblast-independent and -dependent stages and provide the first evidence of decidual leukocyte involvement in trophoblast-independent stages... - Vascular remodeling and extracellular matrix breakdown in the uterine spiral arteries during pregnancyLynda K Harris
Maternal and Fetal Health Research Group, University of Manchester, United Kingdom
Reprod Sci 14:28-34. 2007..Advances in understanding will lead to the identification of the causative factors involved in failure of remodeling in pathological pregnancies and suggest novel diagnostic and therapeutic avenues... - Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanismLynda K Harris
Maternal and Fetal Health Research Centre, Division of Human Development, University of Manchester, St Mary s Hospital, Manchester, UK
Am J Pathol 169:1863-74. 2006..These results suggest that apoptosis triggered by the release of soluble FasL from invading trophoblasts contributes to the loss of smooth muscle from the walls of spiral arteries during pregnancy... - Adhesion molecules in human trophoblast - a review. II. extravillous trophoblastL K Harris
Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
Placenta 30:299-304. 2009.... - IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptorLynda K Harris
Maternal and Fetal Health Research Centre, University of Manchester, Manchester Academic Health Sciences Centre, St Mary s Hospital, Oxford Road, Manchester, UK
Biol Reprod 84:440-6. 2011.... - S-nitrosylation of proteins at the leading edge of migrating trophoblasts by inducible nitric oxide synthase promotes trophoblast invasionLynda K Harris
Maternal and Fetal Health Research Centre, Division of Human Development, University of Manchester, St Mary s Hospital, Manchester, UK
Exp Cell Res 314:1765-76. 2008..We further demonstrate that iNOS plays an important role in promoting trophoblast invasion, which is an essential process in the establishment of a successful pregnancy... - Adhesion molecules in human trophoblast - a review. I. Villous trophoblastJ D Aplin
Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
Placenta 30:293-8. 2009..There is a wide gulf to be filled between molecular anatomy and functional studies, with much to be learned about the role of adhesion molecules in regulating villous epithelial integrity, homeostasis and growth... - Trophoblast-derived heparanase is not required for invasionL K Harris
Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
Placenta 29:332-7. 2008..Its abundant expression suggests another role during pregnancy, perhaps in controlling the availability of ECM-bound growth factors or acting as a transcription factor... - A re-appraisal of the morphophenotype and basal lamina coverage of cytotrophoblasts in human term placentaC J P Jones
University of Manchester, St Mary s Hospital, Manchester M13 0JH, UK
Placenta 29:215-9. 2008..The CT layer thins but maintains a functional network within which cells intercommunicate without compromising substance transfer via the syncytium... - Biology and significance of signalling pathways activated by IGF-IILynda K Harris
Maternal and Fetal Health Research Centre, University of Manchester, UK
Growth Factors 30:1-12. 2012.... - BeWo cells stimulate smooth muscle cell apoptosis and elastin breakdown in a model of spiral artery transformationL K Harris
Maternal and Fetal Health Research Centre, Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester, UK
Hum Reprod 22:2834-41. 2007..Endovascular trophoblast is not easily accessible for studies to establish the pathogenesis of pre-eclampsia, so we have developed a model appropriate to carry out mechanistic studies of vessel wall transformation...