Research Topics
Genomes and GenesSpecies | William HarnettSummaryAffiliation: University of Strathclyde Country: UK Publications
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Publications
Molecular basis of worm-induced immunomodulationW Harnett
Department of Immunology, University of Strathclyde, Glasgow G4 0NR, UK
Parasite Immunol 28:535-43. 2006..It hopes to indicate how knowledge of these factors can explain the changes in gene expression that result in the characteristic worm-induced immunological phenotype...- Phosphorylcholine: friend or foe of the immune system?W Harnett
Dept of Immunology, University of Strathclyde, Glasgow, UK
Immunol Today 20:125-9. 1999..However, as discussed here, PC exhibits a surprising range of immunomodulatory properties that might be to the detriment of the host... - ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potentialWilliam Harnett
Department of Immunology, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
Immunol Lett 94:27-33. 2004..The nematode product was also able to suppress pro-inflammatory cytokine release in vitro in synovial cells derived from RA patients. ES-62 thus constitutes a pathogen-derived immunomodulator with significant therapeutic potential... - Parasitic nematode modulation of allergic diseaseWilliam Harnett
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, United Kingdom
Curr Allergy Asthma Rep 8:392-7. 2008..The article also describes the nature and mode of action of recently characterized nematode-derived molecules with antiallergic properties and highlights their therapeutic efficacy in allergy models... - How do nematodes transfer phosphorylcholine to carbohydrates?William Harnett
Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, UK
Trends Parasitol 26:114-8. 2010.... - Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62William Harnett
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
Adv Exp Med Biol 666:88-94. 2009..As a consequence of this, ES-62 demonstrates striking drug-like activity in models of disease associated with aberrant inflammation, in particular those associated with autoimmunity and allergy... - Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62W Harnett
Department of Immunology, University of Strathclyde, Glasgow, UK
Parasitology 130:S63-8. 2005..In particular we describe how it modulates intracellular signal transduction pathways in a number of different cells of the immune system, in particular B-lymphocytes, T-lymphocytes, macrophages and dendritic cells... - What causes lymphocyte hyporesponsiveness during filarial nematode infection?William Harnett
Department of Immunology, University of Strathclyde, Glasgow, UK
Trends Parasitol 22:105-10. 2006..The consistency of this observation, allied to the ease of measurement of lymphocyte hyporesponsiveness, has resulted in many attempts to understand its cause... - Filarial nematode secreted product ES-62 is an anti-inflammatory agent: therapeutic potential of small molecule derivatives and ES-62 peptide mimeticsWilliam Harnett
Department of Immunology, University of Strathclyde, Glasgow, UK
Clin Exp Pharmacol Physiol 33:511-8. 2006.... - Lymphocyte hyporesponsiveness during filarial nematode infectionW Harnett
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
Parasite Immunol 30:447-53. 2008..As this information continues to be generated, the challenge will be to use it to find a way of reversing lymphocyte hyporesponsiveness in the hope that this will lead to rejection of filarial nematodes in the parasitized human host... - Therapeutic immunomodulators from nematode parasitesWilliam Harnett
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
Expert Rev Mol Med 10:e18. 2008..The recent and future use of nematodes and their products in treating human disease are also discussed... - The anti-inflammatory potential of the filarial nematode secreted product, ES-62William Harnett
Department of Immunology, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
Curr Top Med Chem 4:553-9. 2004..The nematode product was also found to inhibit pro-inflammatory cytokine release in vitro in synovial cells derived from RA patients. ES-62 thus represents a parasite-derived immunomodulator with significant therapeutic potential... - Avoiding detection: parasites and the immune systemWilliam Harnett
Strathclyde Institute for Biochemical Sciences, Glasgow, UK
Biologist (London) 49:222-6. 2002..However, some have become masters of disguise, avoiding the immune system's attack. Parasites are, arguably, kings in this field of evasion of host defences... - Molecular cloning and demonstration of an aminopeptidase activity in a filarial nematode glycoproteinW Harnett
Department of Immunology, University of Strathclyde, The Todd Centre, Glasgow, UK
Mol Biochem Parasitol 104:11-23. 1999..Incubation of ES-62 with leucine-7-amino-4-methylcoumarin as substrate confirmed that ES-62 possessed aminopeptidase activity... - DNA-based detection of onchocerca volvulusWilliam Harnett
Department of Immunology, University of Strathclyde, Glasgow, G4 0NR, Scotland, UK
Trans R Soc Trop Med Hyg 96:S231-4. 2002..g. whether or not strains exist and difficulties in distinguishing the infective larval stage morphologically from related species... - Helminth-derived immunomodulators: can understanding the worm produce the pill?William Harnett
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
Nat Rev Immunol 10:278-84. 2010.... - Modulation of the host immune system by phosphorylcholine-containing glycoproteins secreted by parasitic filarial nematodesW Harnett
Department of Immunology, University of Strathclyde, Glasgow, UK
Biochim Biophys Acta 1539:7-15. 2001.... - Structural/functional aspects of ES-62--a secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoproteinW Harnett
Department of Immunology, University of Strathclyde, Glasgow G4 0NR, UK
Curr Protein Pept Sci 4:59-71. 2003..Such desensitisation reflects ES-62-primed recruitment of a number of negative regulators of these pathways, such as the phosphatases SHP-1 and Pac-1... - Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effectsMaureen R Deehan
Department of Immunology, University of Glasgow, UK
Parasite Immunol 24:463-9. 2002..Overall these data indicate that PC-containing glycosphingolipids of A. suum appear to have at least two immunomodulatory constituents - PC and an as yet unknown component... - In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotypeHelen S Goodridge
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
Immunology 113:491-8. 2004..Such a finding could have important implications for the use of pathogen products or their derivatives for immunotherapy... - A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62Iain B McInnes
Department of Immunology and Center for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom
J Immunol 171:2127-33. 2003..quot; ES-62 represents one such mechanism. We now provide proof of concept that parasite-derived immunomodulatory strategies offer a novel therapeutic opportunity in inflammatory arthritis... - Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivoFraser A Marshall
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
Immunology 123:411-25. 2008..Collectively, these results suggest that whilst ES-62 can target B-T-cell co-operation, this does not promote polarizing of T-cell responses towards a Th2-type phenotype... - Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62Helen S Goodridge
Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
J Immunol 174:284-93. 2005.... - Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62Helen S Goodridge
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
Immunology 115:296-304. 2005..In this review we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode-secreted glycoprotein ES-62 and describe the intracellular signal transduction pathways it targets to achieve these effects... - Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivoEmma H Wilson
Department of Immunology, University of Strathclyde, Glasgow, UK
Immunology 109:238-45. 2003..This finding considerably strengthens the idea that ES-62 plays a role in evasion of the immune response during parasitism... - Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted productHelen S Goodridge
Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
Cell Signal 17:11-6. 2005.... - In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62Emma H Wilson
Department of Immunology, Strathclyde Institute of Biomedical Sciences, University of Strathclyde, Glasgow, UK
Parasite Immunol 25:463-6. 2003.... - Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responsesHelen S Goodridge
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
Immunology 109:415-25. 2003.... - ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivoFraser A Marshall
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
J Immunol 175:5817-26. 2005.... - Investigation of the nature of potential phosphorylcholine donors for filarial nematode glycoconjugatesKatrina M Houston
Department of Immunology, University of Strathclyde, Glasgow G4 0NR, UK
Mol Biochem Parasitol 123:55-66. 2002.... - Differential polarization of immune responses by plant 2S seed albumins, Ber e 1, and SFA8Dorothy E Kean
Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow, UK
J Immunol 177:1561-6. 2006..Overall, our data are consistent with the idea that the ability of Ber e 1, but not SFA8, to act as a potent allergen may reflect differences in their ability to induce IL-12 production... - 19 A solution structure of the filarial nematode immunomodulatory protein, ES-62Claire J Ackerman
Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, United Kingdom
Biophys J 84:489-500. 2003..This study represents the first attempt to understand the multifunctional properties of this important parasite-derived molecule by studying its structure... - Gene inactivation confirms the identity of enzymes involved in nematode phosphorylcholine-N-glycan synthesisKatrina M Houston
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0NR, Strathclyde, United Kingdom
Mol Biochem Parasitol 157:88-91. 2008.... - Immunomodulatory properties of ES-62, a phosphorylcholine-containing glycoprotein secreted by Acanthocheilonema viteaeLamyaa Al-Riyami
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
Endocr Metab Immune Disord Drug Targets 12:45-52. 2012..Overall, ES-62 diverts the immune system towards an anti-inflammatory phenotype and consistent with this it has been shown to have therapeutic potential in models of inflammatory disease associated with autoimmunity and allergy... - Hsp90 is essential in the filarial nematode Brugia pahangiEileen Devaney
Parasitology Group, Division of Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, UK
Int J Parasitol 35:627-36. 2005..Thus, Hsp90 or some of its client proteins may provide novel targets for the chemotherapy of filarial infection... - Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodesAlirio J Melendez
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 2 Medical Drive MD9, Singapore 117597
Nat Med 13:1375-81. 2007..We also show that ES-62 is able to protect mice from mast cell-dependent hypersensitivity in the skin and lungs, indicating that it has potential as a novel therapeutic for allergy... - Parasite modulation of the immune responseWilliam Harnett
Parasite Immunol 27:357-9. 2005 - A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytesRosemary E Smith
Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
Blood 102:2532-40. 2003..MyD-1-coupling to this PI 3-kinase-dependent signaling pathway may therefore present a novel target for the development of therapeutic strategies for combating TNFalpha production and consequent inflammatory disease...