G E Hardingham

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated
    Giles E Hardingham
    Department of Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, Edinburgh University, Summerhall, EH9 1QH, Edinburgh, UK
    Biochim Biophys Acta 1600:148-53. 2002
  2. ncbi 2B synaptic or extrasynaptic determines signalling from the NMDA receptor
    Giles E Hardingham
    Centre for Neuroscience Research, University of Edinburgh, Summerhall Square, Edinburgh EH9 1QH, UK
    J Physiol 572:614-5. 2006
  3. ncbi Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    Antioxid Redox Signal 14:1421-4. 2011
  4. ncbi Pro-survival signalling from the NMDA receptor
    G E Hardingham
    Centre for Neuroscience Research, University of Edinburgh, Summerhall Square, Edinburgh EH9 1QH, UK
    Biochem Soc Trans 34:936-8. 2006
  5. ncbi Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH89XD, UK
    Mol Neurobiol 42:97-102. 2010
  6. ncbi Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, School of Biomedical Sciences, Hugh Robson Building, Edinburgh EH8 9XD, UK
    Nat Rev Neurosci 11:682-96. 2010
  7. ncbi Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection
    Sofia Papadia
    Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Neurosci 25:4279-87. 2005
  8. ncbi Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression
    Marc Andre Martel
    Center for Integrative Physiology, University of Edinburgh, Edinburgh, UK
    Channels (Austin) 3:12-5. 2009
  9. ncbi Coupling of the NMDA receptor to neuroprotective and neurodestructive events
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    Biochem Soc Trans 37:1147-60. 2009
  10. ncbi The Yin and Yang of NMDA receptor signalling
    Giles E Hardingham
    Department of Preclinical Veterinary Sciences, Royal School of Veterinary Studies, Edinburgh University, Summerhall, UK
    Trends Neurosci 26:81-9. 2003

Collaborators

  • David J A Wyllie
  • Chrysanthy Ikonomidou
  • Neil R Hardingham
  • L Ramage
  • D M Salter
  • Siddharthan Chandran
  • Anne Vaslin
  • Karen Horsburgh
  • Henrik H Hansen
  • Stuart Lipton
  • Sangeeta Chawla
  • Francesc X Soriano
  • Sofia Papadia
  • Marc Andre Martel
  • Frederic Leveille
  • Hilmar Bading
  • Paul Baxter
  • Grahame McKenzie
  • Karen F S Bell
  • M A Martel
  • Bashayer Al-Mubarak
  • Colin Rickman
  • Rory Duncan
  • Marc-Andre Martel
  • George Ward
  • Grahame J McKenzie
  • Patrick Stevenson
  • Anna Pokorska
  • Marlen Habel
  • Michael Fricker
  • Clare Puddifoot
  • Aviva M Tolkovsky
  • Peter Ghazal
  • James Varley
  • Marie Craigon
  • Roderick Corriveau
  • Michelle Aarts
  • Joan Forder
  • Jill Fowler
  • Angela Kaindl
  • Larry G Higgins
  • Marco Sifringer
  • Bruce A Yankner
  • Peter Clarke
  • Michael Tymianski
  • Kelly A Dakin
  • Vanya Stefovska
  • John D Hayes
  • Frank Hofmann
  • Emmanuel Briend
  • Andrew Lennard
  • Martin Turner
  • Brian Champion
  • Yvette Stallwood
  • Martin Privalsky
  • Francesca Silvagno
  • Fiona J L Arnold
  • Peter Vanhoutte

Detail Information

Publications26

  1. ncbi Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated
    Giles E Hardingham
    Department of Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, Edinburgh University, Summerhall, EH9 1QH, Edinburgh, UK
    Biochim Biophys Acta 1600:148-53. 2002
    ....
  2. ncbi 2B synaptic or extrasynaptic determines signalling from the NMDA receptor
    Giles E Hardingham
    Centre for Neuroscience Research, University of Edinburgh, Summerhall Square, Edinburgh EH9 1QH, UK
    J Physiol 572:614-5. 2006
  3. ncbi Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    Antioxid Redox Signal 14:1421-4. 2011
    ..Such approaches offer an alternative strategy to classical antioxidant interventions based on the administration of free radical scavengers and spin-traps...
  4. ncbi Pro-survival signalling from the NMDA receptor
    G E Hardingham
    Centre for Neuroscience Research, University of Edinburgh, Summerhall Square, Edinburgh EH9 1QH, UK
    Biochem Soc Trans 34:936-8. 2006
    ..Understanding the mechanisms that underlie these opposing effects may lead to strategies to selectively block pro-death signalling, which could have considerable clinical benefits...
  5. ncbi Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH89XD, UK
    Mol Neurobiol 42:97-102. 2010
    ....
  6. ncbi Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, School of Biomedical Sciences, Hugh Robson Building, Edinburgh EH8 9XD, UK
    Nat Rev Neurosci 11:682-96. 2010
    ..Neuroprotective therapies should aim to both enhance the effect of synaptic activity and disrupt extrasynaptic NMDAR-dependent death signalling...
  7. ncbi Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection
    Sofia Papadia
    Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Neurosci 25:4279-87. 2005
    ..Thus, activity-dependent neuroprotection comprises two mechanistically distinct phases that differ in their spatial requirements for calcium and in their reliance on the CREB family...
  8. ncbi Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression
    Marc Andre Martel
    Center for Integrative Physiology, University of Edinburgh, Edinburgh, UK
    Channels (Austin) 3:12-5. 2009
    ..Thus, while the NR2 PDZ ligand does not account for all the excitotoxic effects of excessive NMDAR activity, these findings underline the value of the specific targeting of death pathways downstream of the NMDAR...
  9. ncbi Coupling of the NMDA receptor to neuroprotective and neurodestructive events
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    Biochem Soc Trans 37:1147-60. 2009
    ..Increased understanding in this field is leading to the discovery of new therapeutic targets and strategies for excitotoxic disorders, as well as a growing appreciation of the harmful consequences of NMDA receptor blockade...
  10. ncbi The Yin and Yang of NMDA receptor signalling
    Giles E Hardingham
    Department of Preclinical Veterinary Sciences, Royal School of Veterinary Studies, Edinburgh University, Summerhall, UK
    Trends Neurosci 26:81-9. 2003
    ....
  11. ncbi In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    M A Martel
    Centre for Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    Neuroscience 158:334-43. 2009
    ..In this instance, subunit differences cannot account for the dichotomous nature of NMDA receptor signaling...
  12. ncbi Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses
    Sofia Papadia
    Centre for Neuroscience Research, University of Edinburgh, Hugh Robson Building George Square, Edinburgh EH8 9XD, UK
    Nat Neurosci 11:476-87. 2008
    ..Thus, synaptic NMDAR activity may influence the progression of pathological processes associated with oxidative damage...
  13. ncbi Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability
    Francesc X Soriano
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom
    J Neurosci 26:4509-18. 2006
    ....
  14. ncbi NMDA receptor expression and activity in osteoarthritic human articular chondrocytes
    L Ramage
    Centre for Inflammation Research, The Queens Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    Osteoarthritis Cartilage 16:1576-84. 2008
    ..This study looks at expression and activity of the ionotropic glutamate NMDA (N-methyl-D-aspartic acid) receptor (NMDAR) in human osteoarthritic (OA) chondrocytes...
  15. ncbi Suppression of the intrinsic apoptosis pathway by synaptic activity
    Frederic Leveille
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    J Neurosci 30:2623-35. 2010
    ..Thus, suppression of apoptotic gene expression may synergize with other activity-dependent events such as enhancement of antioxidant defenses to promote neuronal survival...
  16. ncbi Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene
    Bashayer Al-Mubarak
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
    Channels (Austin) 3:233-8. 2009
    ..These results suggest that FOXO-inactivating signals are likely to result in longer-term inhibition of FOXO target gene expression than previously thought...
  17. ncbi Compartmentalized NMDA receptor signalling to survival and death
    Francesc X Soriano
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, UK
    J Physiol 584:381-7. 2007
    ..A greater understanding of these issues may point to ways of selectively blocking pro-death signalling in neurological disorders such as stroke, where global NMDA receptor antagonists have proved ineffective...
  18. ncbi Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione
    Francesc X Soriano
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh, UK
    J Neurochem 107:533-43. 2008
    ....
  19. ncbi Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand
    Francesc X Soriano
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 28:10696-710. 2008
    ..Thus, NMDAR-activated signals comprise pro-death pathways with differing requirements for PDZ protein interactions. These signals are amenable to selective inhibition, while sparing synaptic plasticity and prosurvival signaling...
  20. ncbi The dichotomy of NMDA receptor signaling
    Sofia Papadia
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh, United Kingdom
    Neuroscientist 13:572-9. 2007
    ..This knowledge may lead to therapeutic strategies that enable the selective blockade of prodeath signaling cassettes while sparing physiological signaling to survival and plasticity...
  21. ncbi Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2
    Francesc X Soriano
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, Sct, UK
    Epigenetics 4:152-8. 2009
    ..Our results indicate that manipulating the histone acetylase-deacetylase balance in neurons may mimic the effects of synaptic activity in preventing the oxidative inactivation of peroxiredoxins...
  22. ncbi Synaptic activity induces signalling to CREB without increasing global levels of cAMP in hippocampal neurons
    Anna Pokorska
    MRC Laboratory of Molecular Biology, Division of Neurobiology, Hills Road, Cambridge, UK
    J Neurochem 84:447-52. 2003
    ....
  23. ncbi Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness
    Grahame J McKenzie
    Lorantis Ltd, Cambridge, UK
    J Neurochem 93:171-85. 2005
    ..Thus, the synaptically controlled kinase-phosphatase balance of the neuron determines the efficacy of SMRT-mediated repression and the signal-responsiveness of a variety of transcription factors...
  24. ncbi Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals
    Grahame McKenzie
    Lorantis Ltd, Cambridge, CB4 0PE, UK
    BMC Cell Biol 7:10. 2006
    ..Mice with disrupted Notch and PI3K signalling show phenotypic similarities during haematopoietic cell development, suggesting functional interaction between these pathways...
  25. ncbi Extracellular calcium regulates postsynaptic efficacy through group 1 metabotropic glutamate receptors
    Neil R Hardingham
    The University Laboratory of Physiology, Oxford University, Oxford OX1 3PT, United Kingdom
    J Neurosci 26:6337-45. 2006
    ..Therefore, physiologically relevant changes in extracellular Ca2+ can regulate information transfer at cortical synapses via both presynaptic and postsynaptic mechanisms...
  26. ncbi Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity
    Neil R Hardingham
    The University Laboratory of Physiology, Oxford University, Oxford, UK
    J Neurophysiol 97:2965-75. 2007
    ..This may represent a means by which distal synapses preferentially increase their efficacy to achieve equal weighting at the soma. Paired activity thus acts to normalize synaptic strength, by both pre- and postsynaptic mechanisms...