Marios Hadjivassiliou

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..To characterize humoral response to cerebellum in patients with gluten ataxia...

..The thigh muscle in the affected leg showed signs of wasting. The patient had a remote family history of celiac disease...

..The sole manifestation of disease in such patients may be ataxia. We describe the clinical, radiological, and neurophysiological features of this disorder...

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..The role of PET in the diagnosis of paraneoplastic neurological syndromes (PNS) has previously been reported in retrospective studies, from specialized neuro-oncology units, often selecting patients with positive paraneoplastic antibodies...

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..Myopathy may be another manifestation of gluten sensitivity and is likely to have an immune-mediated pathogenesis. A gluten-free diet may be a useful therapeutic intervention...

..The high prevalence of gluten sensitivity in patients with stiff-person syndrome (SPS) lead us to investigate the relationship between gluten sensitivity and GAD-antibody-associated diseases...

..IgA deposits against TG2 in the small bowel and at extraintestinal sites are proving to be additional reliable and perhaps more specific markers of the whole spectrum of gluten sensitivity. They may also hold the key to its pathogenesis...

..Knowledge of the diverse manifestations of gluten sensitivity is essential in avoiding such misdiagnosis...

..The commonest type of neuropathy seen in the context of gluten sensitivity is sensorimotor axonal. We report 17 patients with sensory ganglionopathy associated with gluten sensitivity...

..No systematic study of the effect of gluten-free diet on gluten ataxia has ever been undertaken...

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..HLA DQ2 was present in 72% of patients. Gluten ataxia is therefore the single most common cause of sporadic idiopathic ataxia. Antigliadin antibody testing is essential at first presentation of patients with sporadic ataxia...

..The pathophysiology leading to cerebellar damage, loss of Purkinje cells, and the development of ataxia remains speculative, but existing clues are discussed in detail...

..MRI abnormalities varied from confluent areas of high signal throughout the white matter to foci of high signal scattered in both hemispheres. Symptomatic response to gluten-free diet was seen in nine patients...

..Gluten-free diet may thus be a useful therapeutic intervention for patients with gluten neuropathy...

..We have identified a novel neuronal transglutaminase isozyme and investigated whether this enzyme is the target of the immune response in patients with neurological dysfunction...

..We also assessed whether tissue transglutaminase (tTG) antibody is a quantitative marker for histologic severity...

..To determine an effective diagnostic method of detecting all cases of coeliac disease in patients referred for gastroscopy without performing routine duodenal biopsy...

..To establish the prevalence of coeliac disease in the general population and in specific conditions, such as irritable bowel syndrome, iron deficiency anaemia, fatigue and other coeliac-related conditions...

..We identified CD in adults with type 1 diabetes and investigated the effect of a GFD on diabetes-related complications...

..However, there are limited data to support this approach...

..Serum amyloid P component scintigraphy did not show visceral amyloid in extra-cardiac sites, but magnetic resonance imaging indicated diffuse leptomeningeal amyloidosis...

..To determine the incidence and presenting features of adult coeliac disease in a single university hospital in South Yorkshire...

..Unexpectedly, most of these patients showed a notable improvement in their motor symptoms after the introduction of a gluten-free diet...

..In conclusion, this standardised semi-quantitative procedure makes immunohistochemistry a reliable diagnostic test for autoimmune neuropathologies and represents an excellent exclusion test for anti-neural autoimmunity...

..The aim of the present article is to review the knowledge on animal models of gluten sensitivity, as well as reviewing the role of anti-neural antibodies in GA...