Research Topics
| Alison GurneySummaryAffiliation: University of Manchester Country: UK Publications
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Detail Information
Publications
Pulmonary vasoconstrictor action of KCNQ potassium channel blockersShreena Joshi
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G4 0NR, UK
Respir Res 7:31. 2006..We therefore investigated a possible role of KCNQ channels in regulating the function of pulmonary arteries by determining the ability of the selective KCNQ channel blockers, linopirdine and XE991, to promote pulmonary vasoconstriction...
Two-pore potassium channels in the cardiovascular systemAlison Gurney
Faculty of Life Sciences, The University of Manchester, Floor 2, Core Technology Facility, 46 Grafton Street, Manchester M139NT, UK
Eur Biophys J 38:305-18. 2009..As their physiological roles emerge, the K(2P) family of potassium channels may offer promising therapeutic solutions to target cardiovascular diseases...
Effects of streptozotocin-induced diabetes on the pharmacology of rat conduit and resistance intrapulmonary arteriesAlison M Gurney
Faculty of Life Sciences, University of Manchester, Floor 2, Core Technology Facility, 46 Grafton Street, Manchester, M13 9NT, UK
Cardiovasc Diabetol 8:4. 2009..Diabetes was recently shown to be linked to an increased prevalence of pulmonary hypertension. The aim of this study was to determine how the pharmacological reactivity of intrapulmonary arteries is altered in a rat model of diabetes...
Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout miceBoris Manoury
Faculty of Life Sciences, University of Manchester, Manchester, UK
J Physiol 589:3231-46. 2011..The Em was, however, depolarised in comparison with other species.Mouse IKN was much smaller than in rat and showed no sensitivity to pH. The results imply that TASK-1 does not form a functional channel in mouse PASMCs...
