Jane Greatorex

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi The retroviral RNA dimer linkage: different structures may reflect different roles
    Jane Greatorex
    Division of Infectious Diseases, Dept of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Retrovirology 1:22. 2004
  2. ncbi Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity
    Anne L'Hernault
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Retrovirology 4:90. 2007
  3. ncbi Mutation of the Rev-binding loop in the human immunodeficiency virus 1 leader causes a replication defect characterized by altered RNA trafficking and packaging
    Jane S Greatorex
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Gen Virol 87:3039-44. 2006
  4. ncbi Steric block high affinity oligonucleotide analogues: a new tool for mapping RNA-protein binding sites
    Douglas Brown
    Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom
    Nucleosides Nucleotides Nucleic Acids 27:196-212. 2008
  5. ncbi Structure and stability of wild-type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal
    Jane Greatorex
    Department of Medicine, University of Cambridge, Level 5, Addenbrookes Hospital, Hills Road, CB2 2QQ, Cambridge, UK
    J Mol Biol 322:543-57. 2002
  6. ncbi Rev binds specifically to a purine loop in the SL1 region of the HIV-1 leader RNA
    Jose Gallego
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 278:40385-91. 2003

Collaborators

Detail Information

Publications6

  1. ncbi The retroviral RNA dimer linkage: different structures may reflect different roles
    Jane Greatorex
    Division of Infectious Diseases, Dept of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Retrovirology 1:22. 2004
    ..Differences and similarities in both secondary and tertiary structure are discussed. The implication of varying roles for the dimer linkage in related viruses is considered...
  2. ncbi Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity
    Anne L'Hernault
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Retrovirology 4:90. 2007
    ..In this study, we analysed the role of the HIV-2 packaging signal in genomic RNA dimerisation in vivo and its implication in viral replication...
  3. ncbi Mutation of the Rev-binding loop in the human immunodeficiency virus 1 leader causes a replication defect characterized by altered RNA trafficking and packaging
    Jane S Greatorex
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Gen Virol 87:3039-44. 2006
    ..The loop A sequence, which is 98% conserved amongst viral isolates, is implicated in several cis-acting functions critical to virus viability...
  4. ncbi Steric block high affinity oligonucleotide analogues: a new tool for mapping RNA-protein binding sites
    Douglas Brown
    Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom
    Nucleosides Nucleotides Nucleic Acids 27:196-212. 2008
    ..We also demonstrate direct binding of oligonucleotide to their binding sites and confirm this interaction does not alter global RNA conformation, making them highly specific, nondisruptive probes of RNA protein interactions...
  5. ncbi Structure and stability of wild-type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal
    Jane Greatorex
    Department of Medicine, University of Cambridge, Level 5, Addenbrookes Hospital, Hills Road, CB2 2QQ, Cambridge, UK
    J Mol Biol 322:543-57. 2002
    ..In a manner analogous to SL-3, we propose that conformational flexibility at this site may facilitate melting of the structure during Gag protein capture or genomic RNA dimerisation...
  6. ncbi Rev binds specifically to a purine loop in the SL1 region of the HIV-1 leader RNA
    Jose Gallego
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 278:40385-91. 2003
    ..HIV-1 appears to have a second Rev-binding site close to the major splice donor site that may have an additional role in the viral life cycle...