Research Topics
Genomes and GenesSpecies | Ian A GrahamSummaryAffiliation: University of York Country: UK Publications
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Publications
The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisininIan A Graham
Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5YW, UK
Science 327:328-31. 2010..Enrichment for positive QTLs in parents of new high-yielding hybrids confirms that the knowledge and tools to convert A. annua into a robust crop are now available...- Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thalianaStephanie Troufflard
Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
BMC Plant Biol 10:172. 2010..Whether and how K deficient plants also alter their secondary metabolism for nutrient management and defense is not known... - Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvensMargarida R G Maia
Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen AB21 9SB, UK
BMC Microbiol 10:52. 2010..The aim of this study was to investigate the mechanisms by which PUFA affect the growth of B. fibrisolvens, how PUFA are metabolized and the metabolic response to growth in the presence of PUFA... - Pathways of straight and branched chain fatty acid catabolism in higher plantsIan A Graham
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, YO10 5DD, York, UK
Prog Lipid Res 41:156-81. 2002.... - Rational metabolic engineering of transgenic plants for biosynthesis of omega-3 polyunsaturatesIan A Graham
CNAP, Department of Biology Area 7, University of York, PO Box 373, York YO10 5YW, UK
Curr Opin Biotechnol 18:142-7. 2007..In addition, efficient substrate channelling and lipid synthesis could depend on specific endoplasmic reticulum subdomain localisation for key endogenous enzymes, and this organization could be compromised in heterologous systems... - Seed storage oil mobilizationIan A Graham
Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5YW, United Kingdom
Annu Rev Plant Biol 59:115-42. 2008..Both abscisic acid (ABA) and sugars inhibit storage oil mobilization and a substantial degree of the control appears to operate at the transcriptional level... - The Arabidopsis thaliana multifunctional protein gene (MFP2) of peroxisomal beta-oxidation is essential for seedling establishmentElizabeth L Rylott
CNAP, Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
Plant J 45:930-41. 2006..The mfp2-1 aim1double mutant aborted during the early stages of embryo development showing that these two proteins share a common function that is essential for this key stage in the life cycle... - AtTPS1-mediated trehalose 6-phosphate synthesis is essential for embryogenic and vegetative growth and responsiveness to ABA in germinating seeds and stomatal guard cellsLeonardo D Gomez
CNAP, Department of Biology, University of York, Heslington, York YO105DD, UK
Plant J 64:1-13. 2010..Our results show that the TPS1 gene product plays an essential role in regulating the growth of vegetative as well as embryogenic tissue in a mechanism involving ABA and sugar metabolism... - Sucrose rescues seedling establishment but not germination of Arabidopsis mutants disrupted in peroxisomal fatty acid catabolismHelen Pinfield-Wells
CNAP, Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
Plant J 43:861-72. 2005..This demonstrates an additional role beyond that of carbon provision for the beta-oxidation pathway during germination or in dormant seeds... - Arabidopsis ABA INSENSITIVE4 regulates lipid mobilization in the embryo and reveals repression of seed germination by the endospermSteven Penfield
Department of Biology, Centre for Novel Agricultural Products, University of York, York YO10 5YW, United Kingdom
Plant Cell 18:1887-99. 2006..We conclude that the single cell endosperm layer plays an active role in the regulation of seed germination in Arabidopsis... - Fatty acid desaturases from the microalga Thalassiosira pseudonanaThierry Tonon
CNAP, Department of Biology, University of York, Heslington, York, UK
FEBS J 272:3401-12. 2005..Furthermore, we show that one of the remaining genes, TpdesB, encodes a Delta8-sphingolipid desaturase with strong preference for dihydroxylated substrates... - DELLA-mediated cotyledon expansion breaks coat-imposed seed dormancySteven Penfield
Centre for Novel Agricultural Products, Department of Biology, University of York, P O Box 373, York YO10 5YW, United Kingdom
Curr Biol 16:2366-70. 2006..We propose that DELLA-mediated, light-, temperature-, and hormone-responsive cotyledon expansion prior to radicle emergence overcomes dormancy imposed by the seed coat and underlies seed-dormancy control in Arabidopsis... - Cold and light control seed germination through the bHLH transcription factor SPATULASteven Penfield
Center for Novel Agricultural Products, Department of Biology, University of York, P O Box 373, York, YO10 5YW, United Kingdom
Curr Biol 15:1998-2006. 2005..However, the molecular basis of this response has until now been unknown... - Identification of a very long chain polyunsaturated fatty acid Delta4-desaturase from the microalga Pavlova lutheriThierry Tonon
CNAP, Department of Biology, University of York, Heslington, YO10 5YW, York, UK
FEBS Lett 553:440-4. 2003..Thus, PlDES1 is a novel VLCPUFA Delta4-desaturase. Pldes1 expression is four-fold higher during the mid-exponential phase of growth compared to late exponential and stationary phases... - SPATULA links daytime temperature and plant growth rateKate Sidaway-Lee
Department of Biology, University of York, P O Box 373, York YO10 5YW, UK
Curr Biol 20:1493-7. 2010..Our data suggest that SPT integrates time of day and temperature signaling to control vegetative growth rate... - Delayed embryo development in the ARABIDOPSIS TREHALOSE-6-PHOSPHATE SYNTHASE 1 mutant is associated with altered cell wall structure, decreased cell division and starch accumulationLeonardo D Gomez
CNAP, Department of Biology, University of York, Heslington, York YO10 5YW, UK
Plant J 46:69-84. 2006..These results suggest that TPS1 may play a major role in coordinating cell wall biosynthesis and cell division with cellular metabolism during embryo development... - Identification of a fatty acid Delta11-desaturase from the microalga Thalassiosira pseudonanaThierry Tonon
CNAP, Department of Biology, University of York, Heslington, York YO10 5YW, UK
FEBS Lett 563:28-34. 2004..To our knowledge, until this report, Delta11-desaturase activity had only been detected in insect cells... - Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo developmentElizabeth L Rylott
CNAP, Department of Biology, University of York, York YO10 5YW, United Kingdom
J Biol Chem 278:21370-7. 2003..This is the first demonstration of the effects of eliminating (short-chain) beta-oxidation capacity in plants and shows that a functional beta-oxidation cycle is essential in the early stages of embryo development... - An Arabidopsis mutant disrupted in valine catabolism is also compromised in peroxisomal fatty acid beta-oxidationPeter R Lange
Department of Biology, CNAP, Area 7, University of York, Heslington, York YO10 5YW, UK
FEBS Lett 571:147-53. 2004..We also show that CHY1 is repressed in seedlings grown on sugars, which suggests that branched chain amino acid catabolism is transcriptionally regulated by nutritional status... - Analysis of seed phorbol-ester and curcin content together with genetic diversity in multiple provenances of Jatropha curcas L. from Madagascar and MexicoWei He
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York YO10 5DD, United Kingdom
Plant Physiol Biochem 49:1183-90. 2011..curcas is likely to be due to a monogenic trait, which may be under maternal control. We also conducted AFLP analysis and conclude that genetic diversity is very limited in the Madagascan collection compared to the Mexican collection... - Germination and storage reserve mobilization are regulated independently in ArabidopsisSarah L Pritchard
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York YO10 5YW, UK
Plant J 31:639-47. 2002..Two independent programmes appear to operate, one that is blocked by ABA, governing developmental growth resulting in germination; and a second that governs storage lipid mobilization which is largely ABA-independent... - Detoxification of the explosive 2,4,6-trinitrotoluene in Arabidopsis: discovery of bifunctional O- and C-glucosyltransferasesFernando Gandia-Herrero
CNAP, Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
Plant J 56:963-74. 2008..Our results show that UGTs play an integral role in the biochemical mechanism of TNT detoxification by plants... - Trehalose metabolism: a regulatory role for trehalose-6-phosphate?Peter J Eastmond
Centre for Novel Agricultural Products, Department of Biology, Area 7, University of York, PO Box 373, York YO10 5YW, UK
Curr Opin Plant Biol 6:231-5. 2003..In plants, trehalose-6-phosphate also appears to regulate sugar metabolism, but the underlying mechanism is unresolved and may be substantially different from that in yeast... - Oil accumulation in leaves directed by modification of fatty acid breakdown and lipid synthesis pathwaysSteve P Slocombe
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York, UK
Plant Biotechnol J 7:694-703. 2009..This work raises the possibility of producing significant amounts of oil in vegetative tissues of biomass crops such as Miscanthus... - Induction of dormancy in Arabidopsis summer annuals requires parallel regulation of DOG1 and hormone metabolism by low temperature and CBF transcription factorsSarah L Kendall
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York YO10 5DD, United Kingdom
Plant Cell 23:2568-80. 2011.... - A spatiotemporal analysis of enzymatic activities associated with carbon metabolism in wild-type and mutant embryos of Arabidopsis using in situ histochemistrySébastien Baud
Department of Biology, CNAP, University of York, York YO10 5YW, UK
Plant J 46:155-69. 2006..Through the advanced characterization of trehalose-6-P synthase1 (tps1) embryos, this approach finally provides new insight into the regulatory role played by trehalose metabolism in embryo development... - 12-oxo-phytodienoic acid accumulation during seed development represses seed germination in ArabidopsisAnuja Dave
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York YO105DD, United Kingdom
Plant Cell 23:583-99. 2011..These results demonstrate that OPDA acts along with ABA to regulate seed germination in Arabidopsis... - The gluconeogenic enzyme phosphoenolpyruvate carboxykinase in Arabidopsis is essential for seedling establishmentElizabeth L Rylott
Centre for Novel Agricultural Products, Department of Biology (Area 7, University of York, P.O. Box 373, United Kingdom
Plant Physiol 131:1834-42. 2003..We conclude that the 35S-PCK1 antisense seedlings are compromised in the ability to use both storage lipid and storage protein through gluconeogenesis to produce soluble sugars... - Molecular insight into lignocellulose digestion by a marine isopod in the absence of gut microbesAndrew J King
Centre for Novel Agricultural Products, Department of Biology, University of York, PO Box 374, York YO10 5YW, UK
Proc Natl Acad Sci U S A 107:5345-50. 2010..Based on recent studies indicating that these proteins may function as phenoloxidases in isopods, we discuss a possible role for hemocyanins in lignin decomposition... - Is trehalose-6-phosphate a regulator of sugar metabolism in plants?Peter J Eastmond
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York YO10 5YW, UK
J Exp Bot 54:533-7. 2003..Further work is necessary to confirm this hypothesis and determine the underlying mechanism... - Reserve mobilization in the Arabidopsis endosperm fuels hypocotyl elongation in the dark, is independent of abscisic acid, and requires PHOSPHOENOLPYRUVATE CARBOXYKINASE1Steven Penfield
CNAP, Department of Biology, University of York, York YO10 5YW, United Kingdom
Plant Cell 16:2705-18. 2004..These results suggest a model whereby the breakdown of seed carbon reserves is regulated in a tissue-specific manner and shed new light on phytohormonal regulation of the germination process... - Acyl CoA profiles of transgenic plants that accumulate medium-chain fatty acids indicate inefficient storage lipid synthesis in developing oilseedsTony R Larson
Centre for Novel Agricultural Products, Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
Plant J 32:519-27. 2002.... - Expression and manipulation of PHOSPHOENOLPYRUVATE CARBOXYKINASE 1 identifies a role for malate metabolism in stomatal closureSteven Penfield
Department of Biology, Centre for Novel Agricultural Products, University of York, Heslington, York YO10 5DD, UK Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
Plant J 69:679-88. 2012..These results show that malate metabolism is important during dark-induced stomatal closure and that PEPCK is involved in this process... - Trehalose-6-phosphate synthase 1, which catalyses the first step in trehalose synthesis, is essential for Arabidopsis embryo maturationPeter J Eastmond
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
Plant J 29:225-35. 2002..Our data establish for the first time that an enzyme of trehalose metabolism is essential in plants and is implicated in the regulation of sugar metabolism/embryo development via a different mechanism to that reported in S. cerevisiae... - Long chain polyunsaturated fatty acid production and partitioning to triacylglycerols in four microalgaeThierry Tonon
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York YO10 5DD, UK
Phytochemistry 61:15-24. 2002..These two species are therefore good candidates for further biochemical and molecular analysis, in order to understand and manipulate the processes that are responsible for the incorporation of LC-PUFAs into storage oils... - Potential of Jatropha curcas as a source of renewable oil and animal feedAndrew J King
Department of Biology, Centre for Novel Agricultural Products, University of York, Heslington, York YO10 5YW, UK, USA
J Exp Bot 60:2897-905. 2009..The toxic components of J. curcas seeds, the potential for plant breeding to generate improved varieties, and the suitability of J. curcas oil as a feedstock for biodiesel production are discussed... - Arabidopsis seedling growth, storage lipid mobilization, and photosynthetic gene expression are regulated by carbon:nitrogen availabilityThomas Martin
Plant Molecular Science Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Plant Physiol 128:472-81. 2002..Thus, carbon to nitrogen ratio rather than carbohydrate status alone appears to play the predominant role in regulating various aspects of seedling growth including storage reserve mobilization and photosynthetic gene expression... - Yield assessment of integument-led seed growth following targeted repair of auxin response factor 2Rhiannon Hughes
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
Plant Biotechnol J 6:758-69. 2008..We also show that the measurement of the harvest index in Arabidopsis is useful in assessing the impact of introduced traits on the yield... - The coenzyme a biosynthetic enzyme phosphopantetheine adenylyltransferase plays a crucial role in plant growth, salt/osmotic stress resistance, and seed lipid storageSilvia Rubio
Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia Consejo Superior de Investigaciones Cientificas, ES 46022 Valencia, Spain
Plant Physiol 148:546-56. 2008..Taken together, these results suggest that the reaction catalyzed by PPAT is a regulatory step in the CoA biosynthetic pathway that plays a key role for plant growth, stress resistance, and seed lipid storage... - Chewing the fat: beta-oxidation in signalling and developmentAlison Baker
Centre for Plant Sciences, University of Leeds, Leeds LS2 9JT, UK
Trends Plant Sci 11:124-32. 2006..Mutations that disrupt beta-oxidation can have extremely pleiotropic effects, indicating important and varied roles for this pathway throughout the plant life cycle and making this an exciting topic for future research... - An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishmentSilvia Rubio
Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia Consejo Superior de Investigaciones Cientificas, Spain
Plant Physiol 140:830-43. 2006..Taken together, these results provide in vivo evidence for the function of HAL3A and HAL3B, and they point out the critical role of CoA biosynthesis during early postgerminative growth... - Non-coordinate expression of peroxisome biogenesis, beta-oxidation and glyoxylate cycle genes in mature Arabidopsis plantsWayne L Charlton
Centre for Plant Sciences, University of Leeds, Leeds, LS2 9JT, UK
Plant Cell Rep 23:647-53. 2005..These results indicate that, in contrast to cucumber, pumpkin and barley, the glyoxylate cycle does not play a role in the recycling of carbon from the turnover of membrane lipids during senescence and starvation in Arabidopsis... - Jasmonic acid levels are reduced in COMATOSE ATP-binding cassette transporter mutants. Implications for transport of jasmonate precursors into peroxisomesFrederica L Theodoulou
Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, United Kingdom
Plant Physiol 137:835-40. 2005 - Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genomeGuy C Barker
Warwick HRI, University of Warwick, Wellesbourne, Warwick CV35 9EF, United Kingdom
Plant Physiol 144:1827-42. 2007..The assignment of enzyme function to QTL was consistent with the known position of some Brassicaeae candidate genes and collinear regions of the Arabidopsis (Arabidopsis thaliana) genome... - The mitochondrial electron transfer flavoprotein complex is essential for survival of Arabidopsis in extended darknessKimitsune Ishizaki
Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, UK
Plant J 47:751-60. 2006.... - The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvationKimitsune Ishizaki
Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom
Plant Cell 17:2587-600. 2005....