Research Topics
Species | James J GoingSummaryAffiliation: University of Glasgow Country: UK Publications
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Detail Information
Publications
Human breast duct anatomy, the 'sick lobe' hypothesis and intraductal approaches to breast cancerJames J Going
Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow, Scotland, UK
Breast Cancer Res Treat 97:285-91. 2006....- Modified classification for adenocarcinoma of the gastro-oesophageal junctionChristopher J Shearer
Glasgow Royal Infirmary, University Department of Surgery, Glasgow, UK
ANZ J Surg 77:544-9. 2007..Cytokeratin (CK) 7 and 20 immunophenotypes differentiate Barrett's intestinal metaplasia (IM) from gastric IM. Comparing CK immunostaining with Siewert's classification may establish tumour origin and influence surgical choice... - Aberrant expression of TopBP1 in breast cancerJ J Going
Faculty of Medicine, Division of Cancer Sciences and Molecular Pathology, Division of Pathological Sciences, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
Histopathology 50:418-24. 2007..The aim of this study was to determine whether TopBP1 is aberrantly expressed in breast cancer... - Quantifying tumour-infiltrating lymphocyte subsets: a practical immuno-histochemical methodPaula M Loughlin
Section of Surgical Sciences and Translational Research, University of Glasgow, UK
J Immunol Methods 321:32-40. 2007..Efficient histological quantification of tumour-infiltrating T and B lymphocyte (TIL) subsets in archival tissues would greatly facilitate investigations of the role of TIL in human cancer biology. We sought to develop such a method... - Ductal-lobar organisation of human breast tissue, its relevance in disease and a research objective: vector mapping of parenchyma in complete breasts (the Astley Cooper project)James J Going
Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow, UK
Breast Cancer Res 8:107. 2006.... - Molecular pathology and future developmentsJ J Going
Department of Pathology, University of Glasgow, Glasgow Royal Infirmary
Eur J Cancer 35:1895-904. 1999..A further challenge for the biomedical community in the 'genome era' will be to ensure that the benefits of these sophisticated technologies are enjoyed globally... - Stages on the way to breast cancerJ J Going
Glasgow University, Department of Pathology, Western Infirmary, Glasgow G11 6NT, UK
J Pathol 199:1-3. 2003.... - Zoning of mucosal phenotype, dysplasia, and telomerase activity measured by telomerase repeat assay protocol in Barrett's esophagusJames J Going
Department of Pathology, University of Glasgow, Glasgow, Scotland, UK
Neoplasia 6:85-92. 2004..TRAP activity merits evaluation as a candidate biomarker for increased risk of persistent dysplasia and cancer progression in Barrett's esophagus... - 'Senescence-associated' beta-galactosidase activity in the upper gastrointestinal tractJames J Going
Department of Pathology, University of Glasgow, Scotland, UK
J Pathol 196:394-400. 2002..0012). Loss of SAbetaG activity is not, therefore, an early event in glandular dysplasia-neoplasia of the upper gastrointestinal tract... - Escaping from Flatland: clinical and biological aspects of human mammary duct anatomy in three dimensionsJames J Going
Department of Pathology, University of Glasgow, Glasgor Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, Scotland, UK
J Pathol 203:538-44. 2004..While population A ducts appear accessible to duct endoscopy or lavage, population B and population C ducts may be less accessible... - Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosaJ J Going
Department of Pathology, Glasgow University, Glasgow Royal Infirmary, Glasgow, UK
Gut 50:373-7. 2002..Expression is dysregulated in dysplastic states but data for oesophageal squamous mucosa and Barrett's mucosa have not been published... - Epithelial carcinogenesis: challenging monoclonalityJames J Going
Department of Pathology, Glasgow University, Glasgow, UK
J Pathol 200:1-3. 2003.... - Clonal origins of human breast cancerJ J Going
Department of Pathology, University of Glasgow, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK
J Pathol 194:406-12. 2001..Further studies using independent analytical techniques are required to test the important possibility that a significant proportion of mammary carcinomas are not monoclonal... - Observer prediction of HER2 amplification in HercepTest 2+ breast cancers as a potential audit instrumentJames J Going
Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Histopathology 59:333-5. 2011..Indeterminate (2+) HER2 immunohistochemistry (IHC) is usually resolved by FISH for HER2 gene amplification. It was hypothesised that predicting HER2 amplification in IHC 2+ cases could improve audit of HER2 IHC and its interpretation... - Endoscopic mucosal resection for gastroesophageal cancer in a U.K. population. Long-term follow-up of a consecutive seriesAndrew B C Crumley
University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK
Surg Endosc 25:543-8. 2011..We report the long-term results of a consecutive series of 93 endoscopic resections, during a 7-year period, in a U.K. population... - Interrelationships between tumor proliferative activity, leucocyte and macrophage infiltration, systemic inflammatory response, and survival in patients selected for potentially curative resection for gastroesophageal cancerAndrew B C Crumley
University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK
Ann Surg Oncol 18:2604-12. 2011..We examined the interrelationships between standard clinicopathological factors, systemic and local inflammatory responses, tumor proliferative activity, and survival... - IHC for Her2 with CBE356 antibody is a more accurate predictor of Her2 gene amplification by FISH than HercepTest in breast carcinomaR Ainsworth
Department of Pathology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK
J Clin Pathol 58:1086-90. 2005..Negative IHC using CBE356 antibody is 6% more likely to represent a truly negative result than negative staining with HercepTest. Overall, CBE356 was a more accurate predictor of Her2 gene amplification by FISH than HercepTest... - Loss of heterozygosity on chromosomes 11 and 17 are markers of recurrence in TCC of the bladderJ Edwards
University Department of Surgery, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK
Br J Cancer 85:1894-9. 2001..These results suggest that loss of these regions is associated with recurrence of TCC. Further investigation is required to identify genes in these regions, which might be responsible for driving recurrence in TCC of the urinary bladder... - Microdissection and extraction of DNA from archival tissueJoanne Edwards
Division of Cancer and Molecular Pathology, University Department of Surgery, Glasgow Royal Infirmary, Scotland, UK
Methods Mol Med 97:71-5. 2004 - Systematic four-quadrant biopsy detects Barrett's dysplasia in more patients than nonsystematic biopsyJo Etienne Abela
Department of Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom
Am J Gastroenterol 103:850-5. 2008..To compare detection of Barrett's dysplasia and adenocarcinoma by systematic versus nonsystematic surveillance biopsy protocols... - Ras p21 in breast tissue: associations with pathology and cellular localisationJ J Going
Department of Pathology, University Medical School, Edinburgh, UK
Br J Cancer 65:45-50. 1992..Expression in carcinomas was inversely related to oestrogen receptor content but independent of the prognosis-associated variables of size, histological type, vascular invasion or lymph node metastasis... - Genetic aberrations of NAT2 and chromosome 8: their association with progression in transitional cell carcinoma of the urinary bladderA D Watters
Department of Surgery, Glasgow Royal Infirmary, University of Glasgow, Glasgow G31 2ER, UK
Urol Int 67:235-9. 2001..This study evaluated NAT2 and chromosome 8 in sequential tumours from bladder cancer patients to determine if NAT2 alterations increase the risk of progression... - Evaluating HER2 amplification and overexpression in breast cancerJ M Bartlett
University Department of Surgery, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK
J Pathol 195:422-8. 2001..83% with CB11. Of 174 cases negative by FISH, 96% were negative in the Herceptest and 68% with CB11. In conclusion, FISH is the most accurate, reproducible, and precise predictor of HER2 overexpression in routine diagnostic laboratories... - Chromosomal aberrations in transitional cell carcinoma that are predictive of disease outcome are independent of polyploidyJ M Bartlett
University Department of Surgery, Glasgow Royal Infirmary, Scotland, UK
BJU Int 84:775-9. 1999..g. that increased copy numbers for 7 and 17 reflect tumour polyploidy... - Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastasesF Al-Mulla
The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Bearsden, Glasgow, United Kingdom
Genes Chromosomes Cancer 24:306-14. 1999.... - E-cadherin mutation-associated diffuse gastric adenocarcinoma: penetrance and non-penetranceDaniel R Gaya
Department of Gastroenterology, Glasgow Royal Infirmary, UK
Eur J Gastroenterol Hepatol 17:1425-8. 2005..We also speculate on how these patients' undiagnosed genetic haemochromatosis may have influenced the pathology encountered... - What the clinician needs from the pathologist: evidence-based reporting in breast cancerJ J Going
Department of Pathology, University of Glasgow, Scotland, UK
Eur J Cancer 37:S5-17. 2001..Much of the microarray data being put into data-bases has no quality control, and meta-analysis of this data will produce even more conflict than the clinical trials. This can be avoided, as the ability to standardise is available... - Is chromosome 9 loss a marker of disease recurrence in transitional cell carcinoma of the urinary bladder?J M Bartlett
Glasgow University Department of Surgery, Glasgow Royal Infirmary, UK
Br J Cancer 77:2193-8. 1998..It is proposed that loss of chromosome 9 from primary TCC of the urinary bladder identified patients at high risk of recurrence and possible progression... - Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14qF Al-Mulla
Department of Pathology, Faculty of Medicine, Molecular Pathology Unit, Kuwait University, Kuwait
J Clin Pathol 59:624-30. 2006..To investigate the prognostic value for loss of heterozygosity (LOH) of chromosomes 4 and 14q in early-stage colorectal cancer (CRC)... - Expression of the HER1-4 family of receptor tyrosine kinases in breast cancerCaroline J Witton
University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
J Pathol 200:290-7. 2003..The development of HER-targeted agents (eg Herceptin, Iressa), and agents targeted at the downstream signalling pathways, therefore provides new possibilities in the treatment of breast cancer... - A role for BRCA1 in sporadic breast cancerJ A Fraser
University Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK
Br J Cancer 88:1263-70. 2003..BRCA1 protein appears to have a significant role in both sporadic and hereditary breast cancers... - Chromosome 17 aneusomy is associated with poor prognostic factors in invasive breast carcinomaA D Watters
University Department of Surgery, Glasgow Royal Infirmary, Glasgow, Scotland, UK
Breast Cancer Res Treat 77:109-14. 2003.... - Extraction of DNA from microdissected archival tissuesJames J Going
Department of Pathology, Glasgow Royal Infirmary, UK
Methods Mol Biol 226:35-42. 2003 - Positive mobilization margins alone do not influence survival following pancreatico-duodenectomy for pancreatic ductal adenocarcinomaNigel B Jamieson
West of Scotland Pancreatic Unit, Department of Pancreatico Biliary Surgery, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, United Kingdom
Ann Surg 251:1003-10. 2010.... - Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomasSazini Nzula
Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Glasgow, G11 6NT, Scotland, United Kingdom
Cancer Res 63:3275-80. 2003.... - Genetic profiling of stage I and II colorectal cancer may predict metastatic relapseFahd Al-Mulla
Molecular Pathology Laboratory, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
Mod Pathol 19:648-58. 2006..Accordingly, the molecular genetic features of primary tumours should be considered in the mainstream management of patients with this specific stage of the disease... - Expression of telomerase RNA in oesophageal and oral cancerM G Downey
University Departments of Medical Oncology, Pathology and Surgery, University of Glasgow, UK
J Oral Pathol Med 30:577-81. 2001..Generally concordant hTR status between biopsy and resection suggest that biopsy may have a role in selecting candidates for telomerase inhibition therapy... - P-glycoprotein expression in primary breast cancer detected by immunocytochemistry with two monoclonal antibodiesG C Wishart
CRC Department of Medical Oncology, University of Glasgow, UK
Br J Cancer 62:758-61. 1990..Our results suggest that significant levels of P-glycoprotein expression may be present in breast cancer before exposure to drugs associated with multidrug resistance... - Radioimmunohistochemistry of epidermal growth factor receptor in breast cancerKevin W Robertson
Lister Department of Surgery, Glasgow Royal Infirmary, Castle Street, Glasgow G31 2ER, Scotland, UK
Arch Pathol Lab Med 126:177-81. 2002..Conflicting reports of epidermal growth factor receptor (EGFR) expression in breast cancer and inconstant relationships with established prognostic indicators and outcomes suggest difficulties with EGFR measurement... - Scoring nuclear pleomorphism in breast cancerB Dunne
Department of Pathology, Glasgow University and North Glasgow University Hospitals NHS Trust, Glasgow, UK
Histopathology 39:259-65. 2001..Specialists tend to allocate higher pleomorphism scores than non-specialists... - Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15S A Fitzsimmons
Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Glasgow, UK
Oncogene 22:1737-46. 2003..These results suggest the existence of a suppressor of SCC immortality and tumour development at chromosome 6q14.3-q15, which is important to a subset of human SCCs... - Androgen receptor gene methylation and exon one CAG repeat length in ovarian cancer: differences from breast cancerSamar Kassim
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
IUBMB Life 56:417-26. 2004..0001), and women homozygous for the AR CAG repeat were over-represented in the ovarian cancer patients but not in the breast cancer series. These findings reinforce recent suggestions that AR may have a role in ovarian carcinogenesis... - Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patientsFahd Al-Mulla
Kuwait University, Faculty of Medicine, Safat, Kuwait
J Clin Oncol 24:5672-9. 2006..We examined whether RKIP expression in primary colorectal cancers (CRCs) correlates with the risk of metastasis and overall survival... - Progression to detrusor-muscle invasion in bladder carcinoma is associated with polysomy of chromosomes 1 and 8 in recurrent pTa/pT1 tumoursAmanda D Watters
University Department of Surgery, Level II Queen Elizabeth Building, Glasgow Royal Infirmary, G31 2ER, Glasgow, UK
Eur J Cancer 38:1593-9. 2002..009). Investigation of sequential tumours in patients with recurrent and progressive TCC showed that polysomy of chromosomes 1 and 8 were linked to subsequent detrusor muscle invasion, but not recurrence per se... - Identification of loci associated with putative recurrence genes in transitional cell carcinoma of the urinary bladderJoanne Edwards
University Department of Surgery, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK
J Pathol 196:380-5. 2002..Loss of all informative markers, including those residing in the TSC1 region, spanning chromosome 9 was also linked to recurrence...