A Gescher

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line
    E Ann Hudson
    Cancer Biomarkers and Prevention Group, Departments of Biochemistry and Oncology, University of Leicester, Leicester, LE1 7RH, UK
    BMC Cancer 3:2. 2003
  2. ncbi Resveratrol from red grapes - pedestrian polyphenol or useful anticancer agent?
    Andreas J Gescher
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, U K
    Planta Med 74:1651-5. 2008
  3. ncbi Polyphenolic phytochemicals versus non-steroidal anti-inflammatory drugs: which are better cancer chemopreventive agents?
    A Gescher
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies, University of Leicester, Leicester LE2 2LX, UK
    J Chemother 16:3-6. 2004
  4. ncbi Cancer chemoprevention by dietary constituents: a tale of failure and promise
    A J Gescher
    Department of Oncology, University of Leicester, UK
    Lancet Oncol 2:371-9. 2001
  5. ncbi Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum
    Andreas J Gescher
    Cancer Biomarkers and Prevention Research Group, Department of Oncology, University of Leicester, Leicester LE2 7LX, United Kingdom
    Cancer Epidemiol Biomarkers Prev 12:953-7. 2003
  6. ncbi Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells
    J Budworth
    MRC Toxicology Unit, University of Leicester, UK
    Br J Cancer 73:1063-8. 1996
  7. ncbi Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels
    R A Sharma
    Department of Oncology, University of Leicester, Leicester LE1 9HN, United
    Clin Cancer Res 7:1452-8. 2001
  8. ncbi Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells
    J Budworth
    Medical Research Council Toxicology Unit, University of Leicester, UK
    Br J Cancer 75:1330-5. 1997
  9. ncbi Blocking and suppressing mechanisms of chemoprevention by dietary constituents
    M M Manson
    MRC Toxicology Unit, CMHT Hodgkin Building, University of Leicester, Lancaster Road, PO Box 138, Leicester, UK
    Toxicol Lett 112:499-505. 2000
  10. ncbi Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells
    C Courage
    Medical Research Council Toxicology Unit, University of Leicester, UK
    Br J Cancer 74:1199-205. 1996

Collaborators

Detail Information

Publications28

  1. ncbi Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line
    E Ann Hudson
    Cancer Biomarkers and Prevention Group, Departments of Biochemistry and Oncology, University of Leicester, Leicester, LE1 7RH, UK
    BMC Cancer 3:2. 2003
    ..Here, we investigated whether inhibition of ODC by I3C could contribute to a chemopreventive effect in colon cell lines...
  2. ncbi Resveratrol from red grapes - pedestrian polyphenol or useful anticancer agent?
    Andreas J Gescher
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, U K
    Planta Med 74:1651-5. 2008
    ..g., methoxy instead of hydroxy. Some of these derivatives possess more potent pharmacological properties than the lead compound. More work is required to elucidate the role of metabolites in the pharmacological activity of resveratrol...
  3. ncbi Polyphenolic phytochemicals versus non-steroidal anti-inflammatory drugs: which are better cancer chemopreventive agents?
    A Gescher
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies, University of Leicester, Leicester LE2 2LX, UK
    J Chemother 16:3-6. 2004
    ..More clinical evaluation will help establish whether polyphenolic phytochemicals are indeed safe and efficacious alternatives to NSAIDs...
  4. ncbi Cancer chemoprevention by dietary constituents: a tale of failure and promise
    A J Gescher
    Department of Oncology, University of Leicester, UK
    Lancet Oncol 2:371-9. 2001
    ..Pilot clinical trials on the pharmacokinetics and mechanism-based markers of efficacy of the selected intervention should precede phase I-III development in suitable populations...
  5. ncbi Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum
    Andreas J Gescher
    Cancer Biomarkers and Prevention Research Group, Department of Oncology, University of Leicester, Leicester LE2 7LX, United Kingdom
    Cancer Epidemiol Biomarkers Prev 12:953-7. 2003
  6. ncbi Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells
    J Budworth
    MRC Toxicology Unit, University of Leicester, UK
    Br J Cancer 73:1063-8. 1996
    ..Among these compounds CGP 41251 was a very potent MDR-reversing agent with high affinity for P-gp and least affected by P-gp-mediated resistance, rendering it an attractive drug candidate for clinical development...
  7. ncbi Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels
    R A Sharma
    Department of Oncology, University of Leicester, Leicester LE1 9HN, United
    Clin Cancer Res 7:1452-8. 2001
    ....
  8. ncbi Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells
    J Budworth
    Medical Research Council Toxicology Unit, University of Leicester, UK
    Br J Cancer 75:1330-5. 1997
    ..The results suggest that MCF-7/Adr cells lose MDR1 gene expression and PKC activity in a co-ordinate fashion, consistent with the existence of a mechanistic link between MDR1 and certain PKC isoenzymes...
  9. ncbi Blocking and suppressing mechanisms of chemoprevention by dietary constituents
    M M Manson
    MRC Toxicology Unit, CMHT Hodgkin Building, University of Leicester, Lancaster Road, PO Box 138, Leicester, UK
    Toxicol Lett 112:499-505. 2000
    ....
  10. ncbi Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells
    C Courage
    Medical Research Council Toxicology Unit, University of Leicester, UK
    Br J Cancer 74:1199-205. 1996
    ....
  11. ncbi Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells
    E A Hudson
    Medical Research Council Toxicology Unit, University of Leicester, United Kingdom
    Cancer Epidemiol Biomarkers Prev 9:1163-70. 2000
    ..Thus, the consumption of rice bran or brown rice instead of milled white rice may be advantageous with respect to cancer prevention...
  12. ncbi Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells
    R A Sharma
    Oncology Department and MRC Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK
    Carcinogenesis 22:1557-60. 2001
    ..Moreover, they demonstrate the correlation between MDA concentration and M(1)G adduct levels in malignant cells...
  13. ncbi Regulation of P-glycoprotein 1 and 2 gene expression and protein activity in two MCF-7/Dox cell line subclones
    R Davies
    MRC Toxicology Unit, Leicester, UK
    Br J Cancer 73:307-15. 1996
    ..Our analysis of PKC-alpha, 0 and epsilon isozyme levels, and subcellular distribution, shows a co-regulation of expression with P-gp, suggesting a necessary role for PKC in P-gp regulation...
  14. ncbi Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation
    C Courage
    Medical Research Council Toxicology Unit, University of Leicester, UK
    Br J Cancer 71:697-704. 1995
    ..The subcellular distribution of PKC-alpha-, -epsilon and -zeta was measured by Western blot analysis. None of the agents affected PKC-alpha or -zeta.(ABSTRACT TRUNCATED AT 400 WORDS)..
  15. ncbi Colorectal cancer chemoprevention: biochemical targets and clinical development of promising agents
    R A Sharma
    University Department of Oncology, Leicester Royal Infirmary, LE1 5WW, Leicester, UK
    Eur J Cancer 37:12-22. 2001
    ....
  16. ncbi Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues
    T Jones
    MRC Toxicology Unit, University of Leicester, UK
    Biochem Pharmacol 53:1413-8. 1997
    ..CGP 41251 had no effect on PKC-theta in either experimental design. The results show that some, but not all, staurosporine analogues share the partial phorbol ester-agonistic PKC-translocatory activity of the parent molecule...
  17. ncbi Molecular biomarkers of colorectal carcinogenesis and their role in surveillance and early intervention
    G Garcea
    University Department of Oncology, 5th Floor, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, UK
    Eur J Cancer 39:1041-52. 2003
    ..Research should be directed at assessing complementary biomarkers to increase clinical effectiveness in determining management options for patients...
  18. ncbi Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol
    S M Raleigh
    Medical Research Council Toxicology Unit, University of Leicester, PO Box 138, Leicester, LE1 9HN, UK
    Br J Cancer 83:935-40. 2000
    ..The results suggest that administration of isotretinoin via powder aerosol inhalation is probably superior to its application via the oral route in terms of achieving efficacious drug concentrations in the lungs...
  19. ncbi Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta
    P K Gill
    MRC Toxicology Unit, Leicester, UK
    Eur J Biochem 268:4151-7. 2001
    ..The results support the search for therapeutic strategies directed specifically against PKC-alpha to ameliorate resistance of tumours against cytotoxic agents...
  20. ncbi Differences between human breast cell lines in susceptibility towards growth inhibition by genistein
    K Dampier
    MRC Toxicology Unit, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
    Br J Cancer 85:618-24. 2001
    ....
  21. ncbi Lack of correlation between the observed stability and pharmacological properties of S-nitroso derivatives of glutathione and cysteine-related peptides
    J M Tullett
    Medical Research Council Toxicology Unit, University of Leicester, PO Box 138, LE1 9HN, Leicester, United Kingdom
    Biochem Pharmacol 62:1239-47. 2001
    ..It is apparent that the potency of an RSNO in a physiological situation will depend on the concentration of the compound present, the presence of trace metal ions such as copper, and the occurrence of transnitrosation reactions...
  22. ncbi Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production
    C Ireson
    Medical Research Council Toxicology Unit, University of Leicester, United Kingdom
    Cancer Res 61:1058-64. 2001
    ..Because the gastrointestinal tract seems to be exposed more prominently to unmetabolized curcumin than any other tissue, the results support the clinical evaluation of curcumin as a colorectal cancer chemopreventive agent...
  23. ncbi Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin
    S Perkins
    Cancer Biomarkers and Prevention Group, Department of Oncology, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Br J Cancer 88:1480-3. 2003
    ..Thus, the results suggest that in this mouse model aspirin and curcumin act during different 'windows' of neoplastic development...
  24. ncbi Angiogenesis of gastrointestinal tumours and their metastases--a target for intervention?
    G Garcea
    Cancer Studies and Molecular Medicine, 5th Floor, The Robert Kilpatrick Clinical Sciences Building, The Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Cancer 40:1302-13. 2004
    ..However, early results suggest that anti-angiogenic therapy could be an important adjunct to conventional chemotherapy treatment of gastrointestinal neoplasia...
  25. ncbi Generation of a free radical from calphostin C by microsomal cytochrome P450 reductase in rat and human liver
    L H Patterson
    Department of Pharmaceutical Sciences, De Montfort University, Leicester, U K
    Biochem Pharmacol 51:599-603. 1996
    ..Inhibitor and purified enzyme studies showed that cytochrome P450 reductase is responsible for the cal C free radical observed, which is probably a perylenesemiquinone...
  26. ncbi ErbB receptors: possible therapeutic targets in prostate cancer?
    H L Ratan
    Division of Urology, Leicester General Hospital, Leicester, UK
    BJU Int 92:890-5. 2003
  27. ncbi The EORTC Laboratory Research Division. European Organisation for Research and Treatment of Cancer
    N Brunner
    Rigshospitalet, Finsen Laboratory, 8621 Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Eur J Cancer 38:S14-8. 2002
    ....
  28. ncbi Modulation of gene transcription by natural products--a viable anticancer strategy
    M D'Incalci
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Curr Pharm Des 13:2744-50. 2007
    ....