Research Topics
Genomes and Genes | Fanni GergelySummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Centrosomal TACCticsFanni Gergely
Wellcome CR UK Institute, Department of Pharmacology, University of Cambridge, UK
Bioessays 24:915-25. 2002..In this review, I summarise what we already know of this protein family and will use the TACC proteins to illustrate the many facets that centrosomes have developed during the course of evolution...- Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humansRenata Basto
The Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
J Cell Sci 120:1278-87. 2007..Thus, we propose that Hsp90 plays a novel role in regulating the localisation of cyclin B and Msps during mitosis... - Aurora-A: the maker and breaker of spindle polesAlexis R Barr
Cancer Research UK Cambridge Research Institute, Department of Oncology, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK
J Cell Sci 120:2987-96. 2007..Here we discuss recent advances in determining the early mitotic role of Aurora-A, with a strong emphasis on its function at the mitotic spindle poles... - Mitosis: Cdh1 clears the way for anaphase spindle assemblyFanni Gergely
Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Department of Oncology, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK
Curr Biol 18:R1009-12. 2008..Failure to degrade Aurora kinases results in abnormal anaphase microtubule organisation and premature cytokinesis... - Knock-in and knock-out: the use of reverse genetics in somatic cells to dissect mitotic pathwaysAlexis R Barr
Department of Oncology, Cancer Research UK Cambridge Research Institute, University of Cambridge, Cambridge, UK
Methods Mol Biol 545:1-19. 2009..We also mention methods for conditional disruption of essential genes and conclude with specific procedures for the study of mitosis in DT40 cells... - The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cellsFanni Gergely
Department of Pharmacology, University of Cambridge, Wellcome Trust Cancer Research UK Institute, Cambridge CB2 1QR, UK
Genes Dev 17:336-41. 2003..Thus, in human somatic cells, ch-TOG appears to play a major role in organizing spindle poles, and a more minor role in stabilizing spindle microtubules that is, at least in part, mediated via an interaction with TACC3... - WDR62 is associated with the spindle pole and is mutated in human microcephalyAdeline K Nicholas
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
Nat Genet 42:1010-4. 2010.... - Multiple centrosomes: together they stand, divided they fallFanni Gergely
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Department of Oncology, University of Cambridge, Cambridge CB2 0RE, United Kingdom
Genes Dev 22:2291-6. 2008..2189-2203) have set up a genome-wide screen in Drosophila S2 cells. Surprisingly, they found that efficient clustering requires a large number of proteins associated with a variety of cellular functions... - BRCA1-independent ubiquitination of FANCD2Cassandra J Vandenberg
Protein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Mol Cell 12:247-54. 2003..Consequently, while BRCA1 affects the accumulation of FANCD2 at sites of DNA damage, BRCA1/BARD1 E3 ligase activity is not essential for the monoubiquitination of FANCD2... - FANCE: the link between Fanconi anaemia complex assembly and activityPaul Pace
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK
EMBO J 21:3414-23. 2002..Disease-associated FANCC mutants do not bind to FANCE, cannot accumulate in the nucleus and are unable to prevent chromosome breakage...