Jacob George

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Vasc Health Risk Manag 5:265-72. 2009
  2. ncbi Evaluation of the aldosterone-blocking agent eplerenone in hypertension and heart failure
    Jacob George
    Ninewells Hospital, Department of Clinical Pharmacology, Level 7, Dundee DD1 9SY, Scotland, UK
    Expert Opin Pharmacother 8:3053-9. 2007
  3. ncbi High sensitivity troponin T provides useful prognostic information in non-acute chest pain
    J George
    Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    QJM 105:159-66. 2012
  4. ncbi Allopurinol treatment reduces arterial wave reflection in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland
    Cardiovasc Ther 26:247-52. 2008
  5. ncbi Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris
    Narasimharajapura S Rajendra
    Division of Medical Sciences, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
    J Am Coll Cardiol 58:820-8. 2011
  6. ncbi The role of urate and xanthine oxidase inhibitors in cardiovascular disease
    Jacob George
    Department of Clinical Pharmacology, University of Dundee, Dundee, UK
    Cardiovasc Ther 26:59-64. 2008
  7. ncbi Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block
    Douglas H J Elder
    Centre for Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Heart Rhythm 9:505-10. 2012
  8. ncbi The association between serum urate levels and arterial stiffness/endothelial function in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Atherosclerosis 200:374-9. 2008
  9. ncbi High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Circulation 114:2508-16. 2006
  10. ncbi Pulmonary hypertension predicts all-cause mortality in patients with heart failure: a retrospective cohort study
    Benjamin R Szwejkowski
    Centre for Cardiovascular and Lung Biology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Eur J Heart Fail 14:162-7. 2012

Collaborators

Detail Information

Publications14

  1. ncbi Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Vasc Health Risk Manag 5:265-72. 2009
    ..This article aims to explain the role of xanthine oxidase in vascular oxidative stress and to explore the mechanisms by which allopurinol is thought to improve vascular and myocardial indices...
  2. ncbi Evaluation of the aldosterone-blocking agent eplerenone in hypertension and heart failure
    Jacob George
    Ninewells Hospital, Department of Clinical Pharmacology, Level 7, Dundee DD1 9SY, Scotland, UK
    Expert Opin Pharmacother 8:3053-9. 2007
    ..This article reviews the pathophysiology of aldosterone and critically reviews the present evidence for the efficacy and potential role for the new selective aldosterone-receptor antagonist, eplerenone...
  3. ncbi High sensitivity troponin T provides useful prognostic information in non-acute chest pain
    J George
    Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    QJM 105:159-66. 2012
    ..To evaluate the prognostic value of high-sensitivity troponin T (hs-cTnT) in patients who present to General Practitioners (GPs) with non-acute chest pain...
  4. ncbi Allopurinol treatment reduces arterial wave reflection in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland
    Cardiovasc Ther 26:247-52. 2008
    ..A further larger study is warranted to look at whether a therapeutic intervention with allopurinol will impact positively on mortality and morbidity in stroke survivors...
  5. ncbi Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris
    Narasimharajapura S Rajendra
    Division of Medical Sciences, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
    J Am Coll Cardiol 58:820-8. 2011
    ..The aim of this study was to evaluate the effect of high-dose allopurinol on vascular oxidative stress (OS) and endothelial function in subjects with stable coronary artery disease (CAD)...
  6. ncbi The role of urate and xanthine oxidase inhibitors in cardiovascular disease
    Jacob George
    Department of Clinical Pharmacology, University of Dundee, Dundee, UK
    Cardiovasc Ther 26:59-64. 2008
    ....
  7. ncbi Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block
    Douglas H J Elder
    Centre for Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Heart Rhythm 9:505-10. 2012
    ..The use of rennin-angiotensin system blockers (RASBs) may be beneficial in counteracting these potentially harmful effects of right ventricular pacing...
  8. ncbi The association between serum urate levels and arterial stiffness/endothelial function in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Atherosclerosis 200:374-9. 2008
    ..A therapeutic intervention trial of lowering of serum urate is required to see whether this will impact positively on mortality and morbidity in patients with high-risk of strokes...
  9. ncbi High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Circulation 114:2508-16. 2006
    ..The reduction in vascular oxidative stress was profound because high-dose allopurinol totally abolished the oxidative stress that was sensitive to the high-dose vitamin C that was used in this study...
  10. ncbi Pulmonary hypertension predicts all-cause mortality in patients with heart failure: a retrospective cohort study
    Benjamin R Szwejkowski
    Centre for Cardiovascular and Lung Biology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Eur J Heart Fail 14:162-7. 2012
    ..There are insufficient data regarding the risk conferred by increasing severity of PH in patients with heart failure...
  11. ncbi The role of urate and xanthine oxidase in vascular oxidative stress: future directions
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Ther Clin Risk Manag 5:799-803. 2009
    ....
  12. ncbi Thiazolidinediones and the influence of media adverse reporting on prescribing attitudes in practice (TZD-IMPACT) study
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Cardiovasc Ther 27:83-8. 2009
    ..The findings of this study clearly show a need to disseminate reliable drug safety information more effectively to prescribers...
  13. ncbi Drug modification of angiogenesis in a rat cornea model
    Shulamit Schwartz
    Department of Ophthalmology, Assaf Harofeh Medical Center, 6 Weizman Street, Zrifin, Israel
    Invest Ophthalmol Vis Sci 49:250-4. 2008
    ..To evaluate the influence of some widely used antiglaucoma agents on angiogenesis in a novel rat cornea model...
  14. ncbi Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Semin Liver Dis 22:169-83. 2002
    ..Well-known causes of liver injury such as chlorpromazine, phenytoin, and methyldopa are not discussed...