Research Topics
| D GemsSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Evolutionary conservation of regulated longevity assurance mechanismsJoshua J McElwee
Department of Biology, University College London, London WC1E 6BT, UK
Genome Biol 8:R132. 2007..To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS...- Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damageFilipe Cabreiro
Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK
Free Radic Biol Med 51:1575-82. 2011..These findings imply that SOD overexpression increases C. elegans life span, not by removal of O(2)(•-), but instead by activating longevity-promoting transcription factors... - Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasmDavid Weinkove
Department of Biology, University College London, London WC1E 6BT, UK
BMC Biol 4:1. 2006..To address this question we used C. elegans first stage larvae (L1s), which when starved enter a developmentally-arrested diapause stage until food is encountered... - Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?David Gems
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Mech Ageing Dev 126:381-7. 2005..Given the emphasis in this theory on investment in cellular waste disposal, and on protein conservation, we have dubbed it the green theory... - Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?David Gems
Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London, UK
Cell Cycle 8:1681-7. 2009..New challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones. But is the theory really dead, or does it just need to be modified?.. - Interpreting interactions between treatments that slow agingDavid Gems
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Aging Cell 1:1-9. 2002..When considered in the light of these problems, the conclusions of a number of recent lifespan interaction studies appear questionable. We suggest six rules for avoiding the pitfalls that can beset interaction studies... - Insulin/IGF signalling and ageing: seeing the bigger pictureD Gems
Department of Biology, University College London, 4 Stephenson Way, NW1 2HE, London, UK
Curr Opin Genet Dev 11:287-92. 2001..The focus now is on how this pathway is regulated, how it controls nematode ageing, and how this relates to the ageing process in higher animals... - Tragedy and delight: the ethics of decelerated ageingDavid Gems
Institute of Healthy Ageing, and G E E, Darwin Building, University College London, Gower Street, London WC1E 6BT, UK
Philos Trans R Soc Lond B Biol Sci 366:108-12. 2011..Thus, decelerated ageing has an element of tragic inevitability: its benefits to health compel us to pursue it, despite the transformation of human society, and even human nature, that this could entail... - Long-lived dwarf mice: are bile acids a longevity signal?David Gems
Department of Biology, University College London, London, UK
Aging Cell 6:421-3. 2007..This increases resistance to xenobiotic stress, possibly contributing to longevity... - Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assuranceJoshua J McElwee
Department of Biology, University College London, WC1E 6BT, United Kingdom
J Biol Chem 279:44533-43. 2004..By contrast, the daf-16-associated element was enriched in genes down-regulated in dauers and daf-2 mutants. Thus, particular promoter elements appear longevity-associated or aging associated... - Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate proteinD J Clancy
Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
Science 292:104-6. 2001..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved... - Ribosomal protein S6 kinase 1 signaling regulates mammalian life spanColin Selman
Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
Science 326:140-4. 2009..Our results demonstrate that S6K1 influences healthy mammalian life-span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging... - LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegansManoj Nanji
Department of Biology, University College London, London WC1E 6BT, UK
Aging Cell 4:235-45. 2005..Thus, Ras pathway signaling appears to act with insulin/IGF-1 signaling during larval development, but against it during aging... - Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathwaysGlenda Walker
Department of Biology, University College London, Gower Street, WC1E 6BT, UK
Mech Ageing Dev 126:929-37. 2005..elegans is mediated by the TOR pathway is discussed. We conclude that the effect of DR on lifespan is likely to involve multiple mechanisms, which may differ according to the DR regimen used and the organism under study... - Nematode ageing: Putting metabolic theories to the testD Gems
Department of Biology, University College London, 4 Stephenson Way, London, NW1 2HE, UK
Curr Biol 9:R614-6. 1999..New findings support the former, but not the latter interpretation... - An integrated theory of ageing in the nematode Caenorhabditis elegansD Gems
Department of Biology, University College London, UK
J Anat 197:521-8. 2000..This tripartite theory of ageing gives rise to a number of predictions that may be tested experimentally... - Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegansD Gems
The Galton Laboratory, Department of Biology, University College London, England
Genetics 154:1597-610. 2000..This variability was reduced when dead bacteria were used as food. Maintenance on dead bacteria extended both male and hermaphrodite longevity... - Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegansJoshua J McElwee
Department of Biology, University College London, UK
Mech Ageing Dev 127:458-72. 2006..We postulate that this fuels increased somatic maintenance activity, as suggested by the disposable soma theory... - Beyond the evolutionary theory of ageing, from functional genomics to evo-geroLinda Partridge
Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
Trends Ecol Evol 21:334-40. 2006.... - Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in miceColin Selman
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
Physiol Genomics 27:187-200. 2006..Mice undergoing acute CR rapidly adopt many transcriptional and metabolic changes of long-term CR, suggesting that the beneficial effects of CR may require only a short-term reduction in caloric intake... - Sex and death: what is the connection?Linda Partridge
UCL Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
Cell 120:461-72. 2005..Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits... - DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxOEugene Schuster
Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK
Mol Syst Biol 6:399. 2010..This study demonstrates the efficacy of DamID for chromatin profiling in C. elegans... - Stress-response hormesis and aging: "that which does not kill us makes us stronger"David Gems
Institute of Healthy Ageing and Department of Genetics, Environment and Evolution, University College London, London WC1E 6BT, UK
Cell Metab 7:200-3. 2008..The principle of stress-response hormesis is increasingly finding application in studies of aging, where hormetic increases in life span have been seen in several animal models... - Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegansMichelle Keaney
Department of Biology, University College London, WC1E 6BT, UK
Free Radic Biol Med 37:239-50. 2004..This suggests that C. elegans life span is not normally limited by levels of superoxide and its derivatives... - Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegansRyan Doonan
Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
Genes Dev 22:3236-41. 2008..However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2 longevity and constitutive diapause, suggesting a signaling role for sod-4. Overall, these findings imply that O(2)(-) is not a major determinant of aging in C. elegans... - Mechanisms of ageing: public or private?Linda Partridge
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Nat Rev Genet 3:165-75. 2002..As we discuss in this review, this conservation might stem from mechanisms that match reproductive rate to nutrient supply... - Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegansDiana McCulloch
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Exp Gerontol 38:129-36. 2003.... - The evolution of longevityLinda Partridge
Department of Biology, University College London, Darwin Building, Gower Street, WC1E 6BT, London, UK
Curr Biol 12:R544-6. 2002 - Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegansTimothy M Bass
Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
Mech Ageing Dev 128:546-52. 2007..1 mutant animals. We postulate that the effect of resveratrol upon lifespan in C. elegans could reflect induction of phase 2 drug detoxification or activation of AMP kinase... - A lethal side-effectLinda Partridge
Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
Nature 418:921. 2002 - No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effectsJanne M Toivonen
Department of Biology, University College London, London, United Kingdom
PLoS Genet 3:e95. 2007..In addition, we saw no effects on lifespan of expression knockdown of the Indy orthologues nac-2 and nac-3 in the nematode Caenorhabditis elegans... - Benchmarks for ageing studiesLinda Partridge
Centre for Research on Ageing, Department of Biology, University College London, The Darwin Building, Gower Street, London WC1E 6BT, UK
Nature 450:165-7. 2007 - Sex-specific effects of the DAF-12 steroid receptor on aging in Caenorhabditis elegansDiana McCulloch
Cetre for Research on Ageing, Department of Biology, University College London, London WC1E 6BT, UK
Ann N Y Acad Sci 1119:253-9. 2007..These results could imply that in C. elegans, as in mammals, sex differences in steroid endocrinology contribute to sex differences in aging... - Longevity and ageing in parasitic and free-living nematodesD Gems
Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK
Biogerontology 1:289-307. 2000..The possible evolutionary and mechanistic causes of such differences in ageing are discussed... - Defining wild-type life span in Caenorhabditis elegansD Gems
Department of Biology, University College London, England
J Gerontol A Biol Sci Med Sci 55:B215-9. 2000..We infer that the longest-lived N2 variant best resembles the original N2 isolate. This is the N2 male stock currently distributed by the Caenorhabditis Genetics Center... - Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptorDhaval S Patel
Department of Biology, University College London, London, United Kingdom
Genetics 178:931-46. 2008..These studies consolidate and extend our understanding of the complex genetics of daf-2 and its underlying molecular biology... - Erratum to "Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans" [Mech. Ageing Dev. 127 (5) (2006) 458-472]Joshua J McElwee
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Mech Ageing Dev 127:922-36. 2006..We postulate that this fuels increased somatic maintenance activity, as suggested by the disposable soma theory... - No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8Michelle Keaney
Department of Biology, University College London, London, UK
Free Radic Biol Med 34:277-82. 2003..elegans lifespan. Instead we saw a dose-dependent reduction of lifespan and fertility. We conclude that extension of C. elegans lifespan by EUK-8 may only occur under very particular culture conditions... - Evolution of male longevity bias in nematodesDiana McCulloch
Department of Biology, University College London, London WC 1E 6BT, UK
Aging Cell 2:165-73. 2003..This age-independent mortality risk can favour the evolution of rapid aging in females and hermaphrodites relative to males... - Dietary restriction in long-lived dwarf fliesDavid J Clancy
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Science 296:319. 2002 - Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"Colin Selman
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, 5 University Street, London WC1E 6JJ, UK
Science 320:1012; author reply 1012. 2008..However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals... - An abundant, trans-spliced mRNA from Toxocara canis infective larvae encodes a 26-kDa protein with homology to phosphatidylethanolamine-binding proteinsD Gems
Wellcome Research Centre for Parasitic Infections, Department of Biology, Imperial College of Science, Technology and Medicine, London, United Kingdom
J Biol Chem 270:18517-22. 1995..Assays with the T. canis recombinant 26-kDa protein expressed as a fusion with maltose-binding protein have confirmed phosphatidylethanolamine-binding specificity for this novel product... - Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null miceColin Selman
Centre for Diabetes and Endocrinology, Department of Medicine, Rayne Institute, University College London, University St, London, UK
FASEB J 22:807-18. 2008..Our results therefore suggest that IRS1 signaling is an evolutionarily conserved pathway regulating mammalian life span and may be a point of intervention for therapies with the potential to delay age-related processes... - Ageing: Microarraying mortalityDavid Gems
Nature 424:259-61. 2003 - Is more life always better? The new biology of aging and the meaning of lifeDavid Gems
Biology Department, University College, London, England
Hastings Cent Rep 33:31-9. 2003 - Dietary restriction of Caenorhabditis elegans by axenic culture reflects nutritional requirement for constituents provided by metabolically active microbesIsabelle Lenaerts
Department of Biology, Ghent University, Ghent, Belgium
J Gerontol A Biol Sci Med Sci 63:242-52. 2008..Our results suggest that C. elegans has a nutritional requirement for live, metabolically active microbes or, possibly, an unidentified, heat-labile, nonsoluble component present in live microbes... - Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogasterA J Hulbert
Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
Exp Gerontol 39:1137-43. 2004..Thus, individual variation in lifespan in wild-type flies, and life extension by dietary-restriction and reduced insulin/IGF-1 signalling is not attributable to differences in metabolic rate... - Aging in a very short-lived nematodeMichael P Gardner
School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK
Exp Gerontol 39:1267-76. 2004..ratti adults, the shortest-lived nematode described to date, is the consequence of rapid aging, rather than some other, more rapid and catastrophic life-shortening pathology... - What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models?Paul M Brakefield
Institute of Biology, Leiden University, PO Box 9516, 2300 RA Leiden, The Netherlands
Mech Ageing Dev 126:431-8. 2005.... - Effects of sex and insulin/insulin-like growth factor-1 signaling on performance in an associative learning paradigm in Caenorhabditis elegansTibor Vellai
Department of Genetics, Eotvos Lorand University, Budapest, H 1117, Hungary
Genetics 174:309-16. 2006..Potentially, sex and insulin/IGF-1 signaling affect performance in this learning assay via effects on the neurobiology of learning... - Extraordinary plasticity in aging in Strongyloides ratti implies a gene-regulatory mechanism of lifespan evolutionMichael P Gardner
School of Biological Sciences, University of Bristol, Woodland Road, Bristol, UK
Aging Cell 5:315-23. 2006..This suggests that interspecific differences in lifespan may evolve via similar mechanisms... - Dietary restriction in the nematode Caenorhabditis elegansKoen Houthoofd
Department of Biology, Ghent University, K L Ledeganckstraat 35, BE 9000 Ghent, Belgium
Interdiscip Top Gerontol 35:98-114. 2007..Moreover, the well-known insulin/IGF-1 pathway seems not to mediate life-extending effects. One possibility is that target of rapamycin signaling mediates the effects of DR on life span in C. elegans... - RILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor familyAcely Garza-Garcia
Division of Molecular Structure, National Institute for Medical Research, MRC, London, United Kingdom
Hum Mutat 28:660-8. 2007..RILM is available at www.biochem.ucl.ac.uk/RILM...