Research Topics
Species | Clare J FowlerSummaryAffiliation: University College London Country: UK Publications
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Publications
The neural control of micturitionClare J Fowler
University College London, Department of Uro Neurology, London, WC1N 3BG, UK
Nat Rev Neurosci 9:453-66. 2008..This is a major health problem, especially in those with neurological impairment. Here we review the neural control of micturition and how disruption of this control leads to abnormal storage and release of urine...- Bladder afferents and their role in the overactive bladderClare J Fowler
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
Urology 59:37-42. 2002..It is hoped that continued investigation of neurotoxins that have the potential to act on afferent innervation will lead to other treatment strategies for bladder disorders and other disorders involving afferent dysfunction... - Investigation and management of neurogenic bladder dysfunctionC J Fowler
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, UK
J Neurol Neurosurg Psychiatry 74:iv27-iv31. 2003 - Sphincter electromyography in diagnosis of multiple system atrophy: technical issuesSimon Podnar
Institute of Clinical Neurophysiology, University Medical Center Ljubljana, SI 1525 Ljubljana, Slovenia
Muscle Nerve 29:151-6. 2004..At least in diagnostic EMG of MSA patients, late components should be included in the measurement of MUP duration... - Integrated control of lower urinary tract--clinical perspectiveClare J Fowler
Department of Uro Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG
Br J Pharmacol 147:S14-24. 2006.... - A UK consensus on the management of the bladder in multiple sclerosisC J Fowler
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, UK
J Neurol Neurosurg Psychiatry 80:470-7. 2009..The management of urinary tract infections as well as the bladder problems as part of severe disability were discussed and recommendations agreed... - A decade of functional brain imaging applied to bladder controlClare J Fowler
Institute of Neurology, UCL, London, UK
Neurourol Urodyn 29:49-55. 2010..Some studies have also been carried out using functional imaging methods to examine pathophysiological bladder conditions or the effect of treatments and these are reviewed and future work anticipated... - Update on the neurology of Parkinson's diseaseClare J Fowler
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
Neurourol Urodyn 26:103-9. 2007..Bladder symptoms in a man with lesser neurological disability should be investigated to exclude underlying outflow obstruction. Possible management options are considered... - A UK consensus on the management of the bladder in multiple sclerosisC J Fowler
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Postgrad Med J 85:552-9. 2009..The management of urinary tract infections as well as the bladder problems as part of severe disability were discussed and recommendations agreed... - Review of neurologic diseases for the urologistClare J Fowler
UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, UCLH, Box 71, Queen Square, London WC1N 3BG, UK
Urol Clin North Am 37:517-26. 2010..The advances in treatments for multiple sclerosis in recent years have been remarkable and are briefly described... - Investigational techniquesC J Fowler
Institute of Neurology, University College London, Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, UK
Eur Urol 34:10-2. 1998.... - The perspective of a neurologist on treatment-related research in fecal and urinary incontinenceClare J Fowler
Institute of Neurology and Institute of Urology, UCL, National Hospital for Neurology and Neurosurgery, London, England
Gastroenterology 126:S172-4. 2004..Development of methods of enhancing the inhibitory reflex effect could lead to improved voluntary control of micturition and defecation for patients with neurogenic bladder overactivity or spinal cord lesions... - Comparison of the impact on health-related quality of life of repeated detrusor injections of botulinum toxin in patients with idiopathic or neurogenic detrusor overactivityXavier Game
Department of Uro Neurology, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, and Medical Research Council MRC Centre for Transplantation, King s College London, London, UK
BJU Int 107:1786-92. 2011..Therapy (case series)... - Cadherin-11 up-regulation in overactive bladder suburothelial myofibroblastsAlexander Roosen
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom
J Urol 182:190-5. 2009.... - Sacral neurostimulation for urinary retention: 10-year experience from one UK centreSoumendra N Datta
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, UK
BJU Int 101:192-6. 2008.... - Histological changes in the urothelium and suburothelium of human overactive bladder following intradetrusor injections of botulinum neurotoxin type A for the treatment of neurogenic or idiopathic detrusor overactivityApostolos Apostolidis
Institute of Neurology, UCL, London, United Kingdom
Eur Urol 53:1245-53. 2008.... - Suburothelial myofibroblasts in the human overactive bladder and the effect of botulinum neurotoxin type A treatmentAlexander Roosen
Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, UK
Eur Urol 55:1440-8. 2009..An increasing body of evidence suggests a possible role of suburothelial myofibroblasts (MFs) in bladder mechanosensation and in the pathophysiology of detrusor overactivity (DO)... - Botulinum injections for the treatment of bladder symptoms of multiple sclerosisVinay Kalsi
Institute of Neurology and Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
Ann Neurol 62:452-7. 2007..Our objective was to demonstrate the efficacy and impact on quality of life of detrusor injections of botulinum neurotoxin type A in the treatment of bladder dysfunction in patients with multiple sclerosis... - Quality of life changes in patients with neurogenic versus idiopathic detrusor overactivity after intradetrusor injections of botulinum neurotoxin type A and correlations with lower urinary tract symptoms and urodynamic changesVinay Kalsi
Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
Eur Urol 49:528-35. 2006..In contrast to urodynamic parameters, changes in LUTS appear to be the major determinants of improvements in the patients' QOL... - What a patient with refractory idiopathic detrusor overactivity should know about botulinum neurotoxin type a injectionShahid Khan
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom
J Urol 181:1773-8. 2009.... - Long-term effect on quality of life of repeat detrusor injections of botulinum neurotoxin-A for detrusor overactivity in patients with multiple sclerosisShahid Khan
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom
J Urol 185:1344-9. 2011..We studied the effect of repeat detrusor botulinum neurotoxin type A injections on urinary symptoms, health and quality of life in patients with refractory neurogenic detrusor overactivity secondary to multiple sclerosis... - Assessment of urodynamic and detrusor contractility variables in patients with overactive bladder syndrome treated with botulinum toxin-A: is incomplete bladder emptying predictable?Arun Sahai
Department of Urology, Guy s Hospital and KCL School of Medicine, London, UK
BJU Int 103:630-4. 2009.... - Cost-consequence analysis evaluating the use of botulinum neurotoxin-A in patients with detrusor overactivity based on clinical outcomes observed at a single UK centreVinay Kalsi
The National Hospital for Neurology and Neurosurgery, London, UK
Eur Urol 49:519-27. 2006..CONCLUSION(S): This study demonstrates that intra-detrusor BoNT/A is an effective treatment for OAB that is highly likely to be cost-effective in both idiopathic and neurogenic disease... - Results of double-blind placebo-controlled crossover study of sildenafil citrate (Viagra) in women suffering from obstructed voiding or retention associated with the primary disorder of sphincter relaxation (Fowler's Syndrome)Soumendra N Datta
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
Eur Urol 51:489-95; discussion 495-7. 2007..The aim of our study was to determine if sildenafil could improve sphincter relaxation and thereby increase flow rates and improve bladder emptying... - Early effect on the overactive bladder symptoms following botulinum neurotoxin type A injections for detrusor overactivityVinay Kalsi
Institute of Neurology, UCL, London, United Kingdom
Eur Urol 54:181-7. 2008..We studied the immediate effect of BoNTA on the OAB symptoms by recording the daily changes during the week after treatment of patients with neurogenic or idiopathic detrusor overactivity (NDO/IDO)... - Complete continence after botulinum neurotoxin type A injections for refractory idiopathic detrusor overactivity incontinence: patient-reported outcome at 4 weeksShahid Khan
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
Eur Urol 57:891-6. 2010.... - Clean intermittent self-catheterization after botulinum neurotoxin type A injections: short-term effect on quality of lifeThomas M Kessler
Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, University College London Institute of Neurology, London, United Kingdom
Obstet Gynecol 113:1046-51. 2009.... - Neurogenic detrusor overactivity in patients with spinal cord injury: evaluation and managementArun Sahai
Department of Urology and Medical Research Council MRC Centre for Transplantation, King s College London, King s Health Partners, Guy s Hospital, London, UK
Curr Urol Rep 12:404-12. 2011..Recent and relevant publications in these areas will be summarized and discussed... - Immunohistochemical expression of muscarinic receptors in the urothelium and suburothelium of neurogenic and idiopathic overactive human bladders, and changes with botulinum neurotoxin administrationSoumendra N Datta
Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, University College London Hospital, London, United Kingdom
J Urol 184:2578-85. 2010..We also examined associations with patient quantified symptoms and the effect of intradetrusor botulinum neurotoxin type A treatment... - Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxinApostolos Apostolidis
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
Urology 65:400-5. 2005..In patients with NDO, TRPV1 suburothelial nerve density is increased, which is reversed by successful treatment with intravesical RTX. However, the role of urothelial TRPV1 in human bladder disorders is unknown... - In the human urothelium and suburothelium, intradetrusor botulinum neurotoxin type A does not induce apoptosis: preliminary resultsThomas M Kessler
Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, and University College London Institute of Neurology, Queen Square, London, UK
Eur Urol 57:879-83. 2010..In animal experiments, intradetrusor BoNTA injections have been shown to cause apoptosis in the bladder urothelium and suburothelium but not the detrusor... - A comparison between the response of patients with idiopathic detrusor overactivity and neurogenic detrusor overactivity to the first intradetrusor injection of botulinum-A toxinRoshni Popat
Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, United Kingdom
J Urol 174:984-9. 2005..CONCLUSIONS: Patients with intractable IDO respond to intradetrusor BoNT/A with equally significant improvements in urodynamic and lower urinary tract symptom parameters as those with spinal NDO, despite the lower dose of toxin used... - Successful treatment with botulinum toxin A after failed augmentation ileocystoplastyApostolos Apostolidis
Institute of Neurology, University College London, London, UK
Nat Clin Pract Urol 4:280-4. 2007.... - Effect of intravesical Resiniferatoxin (RTX) on lower urinary tract symptoms, urodynamic parameters, and quality of life of patients with urodynamic increased bladder sensationApostolos Apostolidis
The National Hospital for Neurology and Neurosurgery, Department of Uro-Neurology, Internal mailbox 71, Queen Square, London WC1N 3BG, UK
Eur Urol 50:1299-305. 2006.... - Long-term results of sacral neuromodulation for women with urinary retentionRanan Dasgupta
National Hospital for Neurology and Neurosurgery, Department of Uro Neurology, Queen Square, London, UK
BJU Int 94:335-7. 2004..OBJECTIVE ; To review the long-term results of sacral nerve stimulation in the treatment of women with Fowler's syndrome, over a 6-year period at one tertiary referral centre... - Urinary retention in women: its causes and managementRajesh B C Kavia
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, UK
BJU Int 97:281-7. 2006..05). CONCLUSION: These investigations helped to classify the cause of retention in two-thirds of cases. The commonest diagnosis was Fowler's syndrome, in which sacral nerve stimulation is the only intervention that restores voiding... - Maximum urethral closure pressure and sphincter volume in women with urinary retentionOliver J Wiseman
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
J Urol 167:1348-51; discussion 1351-2. 2002..Urethral pressure profilometry and sphincter volume measurement are useful for assessing these cases, especially when sphincter electromyography is not readily available... - Urodynamic study of women in urinary retention treated with sacral neuromodulationRanan Dasgupta
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
J Urol 171:1161-4. 2004..The modest increase in detrusor pressure appears to be sufficient to overcome the resistance of the overactive sphincter... - Sacral neuromodulation for urinary retentionThomas M Kessler
Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
Nat Clin Pract Urol 5:657-66. 2008.... - Proposed mechanism for the efficacy of injected botulinum toxin in the treatment of human detrusor overactivityApostolos Apostolidis
Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
Eur Urol 49:644-50. 2006..The summation of these effects is a profound and long-lasting inhibition of those afferent and efferent mechanisms that are thought to be the pathophysiological basis for DO... - Benign prostatic obstruction and parkinson's disease--should transurethral resection of the prostate be avoided?Beat Roth
Department of Urology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, University College London Institute of Neurology, London, United Kingdom
J Urol 181:2209-13. 2009..Therefore, we investigated the outcome of transurethral prostate resection in patients with a secure neurological diagnosis of Parkinson's disease... - Changes in brain activity following sacral neuromodulation for urinary retentionRanan Dasgupta
Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WCIN 3BG, United Kingdom
J Urol 174:2268-72. 2005..Therefore, we undertook a functional brain imaging study to determine how neuromodulation acts on brain centers involved in the representation and control of bladder function... - Therapy Insight: bladder dysfunction associated with multiple sclerosisVinay Kalsi
National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Nat Clin Pract Urol 2:492-501. 2005..The diminishing role of surgical intervention is also discussed... - Techniques for the intradetrusor administration of botulinum toxinArun Sahai
Urology, Guy's and St. Thomas' NHS Trust and GKT School of Medicine, and Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, UK
BJU Int 97:675-8. 2006 - Sexual dysfunction in multiple sclerosisThomas M Kessler
Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, UCL NHS Foundation Trust, UCL Institute of Neurology, London, UK
Expert Rev Neurother 9:341-50. 2009..Specific pharmacotherapy is only currently available for erectile dysfunction. This review summarizes the available information about sexual dysfunction in men and women with multiple sclerosis... - A double blind, randomised study of sildenafil citrate for erectile dysfunction in men with multiple sclerosisC J Fowler
Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, Mailbox 71, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 76:700-5. 2005..Identifying and effectively treating erectile dysfunction (ED) can result in an improvement of the quality of life (QoL) in men with multiple sclerosis (MS)... - Effects of botulinum toxin B on refractory detrusor overactivity: a randomized, double-blind, placebo controlled, crossover trialM Ghei
Department of Urology, Whittington Hospital, London, United Kingdom
J Urol 174:1873-7; discussion 1877. 2005..We tested the efficacy and safety of botulinum toxin B for the treatment of the overactive bladder in a randomized, double-blind, placebo controlled crossover trial... - Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotensionI F Hussain
Uro-Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 71:371-4. 2001..Furthermore, such patients should be made aware of seeking medical advice if they develop symptoms on treatment suggestive of orthostatic hypotension... - Efficacy of sildenafil in the treatment of female sexual dysfunction due to multiple sclerosisRanan Dasgupta
Departmetn of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
J Urol 171:1189-93; discussion 1193. 2004..However, it could not predict the extent of sexual dysfunction. Sildenafil is unlikely to help all patients with neurogenic female sexual dysfunction... - Bladder, bowel and sexual dysfunction in multiple sclerosis: management strategiesRanan Dasgupta
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Drugs 63:153-66. 2003..This review highlights the strategies for these types dysfunction commonly seen in patients with MS, with report of recent pharmacological developments... - The ultrastructure of bladder lamina propria nerves in healthy subjects and patients with detrusor hyperreflexiaOliver J Wiseman
Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery and Institute of Neurology, London, United Kingdom
J Urol 168:2040-5. 2002..Some possible functional aspects of observed structural interrelationships are presented... - Bowel biofeedback treatment in patients with multiple sclerosis and bowel symptomsGiuseppe Preziosi
GI Physiology Unit, University College London Hospital, London, United Kingdom
Dis Colon Rectum 54:1114-21. 2011..Bowel symptoms are common in patients with multiple sclerosis, but current treatment is empirical... - Cerebral mechanisms and voiding functionRanan Dasgupta
National Hospital for Neurology, Uro Neurology, London, UK
BJU Int 99:731-4. 2007..This area has generated much interest and is something for which we should develop a full understanding, to optimise our treatments for this condition... - The management of female voiding dysfunction: Fowler's syndrome -- a contemporary updateRanan Dasgupta
Department of Uro Neurology, National Hospital for Neurology and Neursurgery, London, UK
Curr Opin Urol 13:293-9. 2003..Recently there have been advances in the stimulator implantation technique, as well as in our appreciation of its mechanism of action... - An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosisC M Brady
Dept of Uro-Neurology, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Mult Scler 10:425-33. 2004..There were few troublesome side effects, suggesting that cannabis-based medicinal extracts are a safe and effective treatment for urinary and other problems in patients with advanced MS... - Sexual and urological dysfunction in multiple sclerosis: better understanding and improved therapiesRanan Dasgupta
Department of UroNeurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Curr Opin Neurol 15:271-8. 2002..Female sexual dysfunction is also now gaining some attention, with new classification criteria and methods for assessing and treating these patients... - Rehabilitation in practice: neurogenic lower urinary tract dysfunction and its managementJalesh N Panicker
Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, UCL Institute of Neurology, London, UK
Clin Rehabil 24:579-89. 2010..Understanding of the underlying mechanism of lower urinary tract dysfunction is crucial for effective management... - The cause and natural history of isolated urinary retention in young womenMichael J Swinn
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
J Urol 167:151-6. 2002..Neurological investigation in these women does not reveal underlying neurological disease. It is thought that this disorder is due to a primary failure of relaxation of the striated urethral sphincter... - Is sphincter electromyography a helpful investigation in the diagnosis of multiple system atrophy? A retrospective study with pathological diagnosisDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, London, United Kingdom
Mov Disord 20:1425-30. 2005..A normal spEMG is unlikely in pathologically proven MSA, at least in cases with a mean symptom duration of more than 5 years when the test is performed... - Urinary incontinence following deep brain stimulation of the pedunculopontine nucleusIciar Aviles-Olmos
Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Acta Neurochir (Wien) 153:2357-60. 2011..Proximity between caudal PPN and brainstem structures implicated in control of micturition is a possible explanation... - P2X3-immunoreactive nerve fibres in neurogenic detrusor overactivity and the effect of intravesical resiniferatoxinCiaran M Brady
Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
Eur Urol 46:247-53. 2004..There was a significant decrease in P2X3 immunoreactivity in responders to RTX, indicating a potential pathophysiological role for the P2X3 expressing fibres... - Pressure-flow study as an evaluating method of neurogenic urethral relaxation failureR Sakakibara
Uro Neurology Department, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
J Auton Nerv Syst 80:85-8. 2000..The results also indicated a relationship between detrusor hyperreflexia and obstructed pattern, probably reflecting co-occurrence of detrusor hyperreflexia with DESD or detrusor-internal sphincter dyssynergia... - Sacral neuromodulation and pregnancyO J Wiseman
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
J Urol 167:165-8. 2002..Elective cesarean section should be discussed since it is possible for sacral lead damage or displacement to occur during vaginal delivery... - Parallel changes in bladder suburothelial vanilloid receptor TRPV1 and pan-neuronal marker PGP9.5 immunoreactivity in patients with neurogenic detrusor overactivity after intravesical resiniferatoxin treatmentC M Brady
Department of Uro-Neurology, Institute of Neurology, Queen Square, London, UK
BJU Int 93:770-6. 2004..As baseline nerve fibre values were similar in responders and nonresponders, an additional factor may account for the difference in treatment outcome... - Urinary retention in womenC J Fowler
Department of Uro-Neurology, The Institute of Neurology, University College London, UK
BJU Int 91:463-4. 2003 - Isolated urinary retention in young women, or Fowler's syndromeM J Swinn
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
Clin Auton Res 11:309-11. 2001..The retention is unlikely to resolve but is not associated with the development of other disorders. Neuromodulation of the sacral nerves is the only intervention that has been demonstrated to restore voiding... - Structural assessment of the urethral sphincter in women with urinary retentionD E Andrich
Institute of Urology, London, United Kingdom
J Urol 173:1246-51. 2005..It was suggested this sphincter overactivity could lead to work hypertrophy of the urethral rhabdosphincter and in this study we looked for any evidence of such muscle fiber hypertrophy... - Voiding and MRI analysis of the brainR Sakakibara
National Hospital for Neurology and Neurosurgery, London, UK
Int Urogynecol J Pelvic Floor Dysfunct 10:192-9. 1999..We have also had the opportunity to make observations about the role of the basal ganglia and pons in micturition control in humans... - Muscle disease, HIV and zidovudine: the spectrum of muscle disease in HIV-infected individuals treated with zidovudineH Manji
Department of Neurological Studies, University College and Middlesex Hospital School of Medicine, London, UK
J Neurol 240:479-88. 1993..In those patients with severe weakness, and with biopsy findings of necrosis and inflammation, the drug effects may be difficult to separate from the primary effects of HIV... - Botulinum toxin for the treatment of lower urinary tract symptoms: a reviewA Sahai
Department of Urology, Guy's Hospital, London, United Kingdom
Neurourol Urodyn 24:2-12. 2005..CONCLUSIONS: Application of botulinum toxin in the lower urinary tract has produced promising results in treating lower urinary tract dysfunction, which needs further evaluation with randomised, placebo-controlled trials... - The use of botulinum neurotoxin type A (BoNTA) in urologyA Apostolidis
Institute of Neurology, University College London, London, UK
J Neural Transm 115:593-605. 2008..This review aims to provide an insight of the use of BoNT/A in the lower urinary tract, addressing issues such as treatment outcomes and safety, mechanisms of action and potential for future research... - Endothelial nitric oxide synthase expression in neurogenic urinary bladders treated with intravesical resiniferatoxinA N Apostolidis
Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
BJU Int 93:336-40. 2004..Further studies with more patients are required to confirm this relationship and to examine the mechanisms underlying changes in vasculature with levels of bladder overactivity... - Botulinum toxin and its applications in the lower urinary tractM Harper
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, UK
BJU Int 93:702-6. 2004 - After a decade of intravesical vanilloid therapy: still more questions than answersArpad Szallasi
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Lancet Neurol 1:167-72. 2002..Drugs that target signalling mechanisms that bring about these changes in gene expression have obvious therapeutic potential... - A minimally invasive technique for outpatient local anaesthetic administration of intradetrusor botulinum toxin in intractable detrusor overactivityApostolos Apostolidis
BJU Int 96:917-8. 2005 - Sexual function in men and women with neurological disordersPeter M Rees
Burnaby Hospital, Neurology Department, Burnaby, BC, Canada
Lancet 369:512-25. 2007..Nerve-sparing techniques could mitigate the substantial sexual dysfunction in both men and women through surgical disruption of the autonomic nerves during radical pelvic surgery... - Bladder dysfunction in Parkinsonism: mechanisms, prevalence, symptoms, and managementKristian Winge
Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark
Mov Disord 21:737-45. 2006..The management of bladder dysfunction in Parkinsonism addresses treatment of overactive detrusor as well as incontinence...