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Genomes and Genes | Stephen M FitzjohnSummaryAffiliation: University of Bristol Country: UK Publications
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Publications
A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1Stephen M Fitzjohn
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, UK
Mol Brain 3:21. 2010..These data show that a prolonged, substantially elevated level of Abeta are not sufficient to cause deficits in the induction or expression of LTP in the CA1 hippocampal region...- Disruption of the interaction between myosin VI and SAP97 is associated with a reduction in the number of AMPARs at hippocampal synapsesJoanne E Nash
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK
J Neurochem 112:677-90. 2010..e. 'silent' synapses). Together, these results indicate that myosin VI/SAP97 plays an important role in trafficking and activity-dependent recruitment of AMPARs to synapses... - ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre functionSheila L Dargan
MRC Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, UK
Neuropharmacology 56:121-30. 2009..Taken together our data provide further evidence for a physiological role of GluK1-containing KARs in synaptic facilitation and LTP induction at mossy fibre-CA3 synapses... - Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampusThomas E Bartlett
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
Neuropharmacology 52:60-70. 2007..4 microM. The lack of effect of 0.1 microM NVP on LTD contrasts with its marked effect on LTP and raises the possibility that different NVP-sensitive NR2 subunit-containing NMDA receptors are required for LTP and LTD in this preparation... - The use of the hippocampal slice preparation in the study of Alzheimer's diseaseStephen M Fitzjohn
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
Eur J Pharmacol 585:50-9. 2008..iv) The identification of a mechanism that can account for the cognitive enhancing effects of the NMDA receptor antagonist memantine. (v) The discovery of a role of glycogen synthase kinase-3beta (tau kinase) in synaptic plasticity... - Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRsThomas M Sanderson
MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, UK
Mol Brain 4:30. 2011..The implications of these findings for the initial mechanisms of expression of both NMDA receptor- and mGluR-induced LTD are discussed... - LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expressionVanessa J Appleby
MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, UK
J Neurochem 116:530-43. 2011..CaMKII activation is therefore an important factor in the activity-dependent recruitment of native GluA1 subunit-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors to the cell surface of hippocampal neurons... - Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1Robin A Morton
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University of Walk, Bristol BS8 1TD, UK
Neurosci Lett 319:37-40. 2002..These results demonstrate that chronic reduction of PS1 activity leads to impaired synaptic plasticity, thus suggesting a role for PS1 in normal cognitive function... - Promiscuous interactions between AMPA-Rs and MAGUKsStephen M Fitzjohn
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
Neuron 52:222-4. 2006..In this issue of Neuron, Elias et al. have elucidated the roles of three MAGUKs, PSD-95, PSD-93, and SAP-102, in the targeting of AMPA receptors to synapses in hippocampal neurons... - Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depressionPeter R Moult
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
J Physiol 586:2499-510. 2008..These data therefore demonstrate that a novel combination of signalling cascades, requiring both activation of p38 MAPK and tyrosine de-phosphorylation, underlies the induction of synaptically induced mGluR-LTD... - GLUK1 receptor antagonists and hippocampal mossy fiber functionRobert Nistico
Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
Int Rev Neurobiol 85:13-27. 2009..In particular, we show that the GluK1-containing KARs are important for regulating synaptic facilitation and LTP induction at hippocampal mossy fiber synapses... - Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depressionPeter R Moult
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
J Neurosci 26:2544-54. 2006..Together, these data suggest that activation of postsynaptic PTP results in tyrosine dephosphorylation of AMPARs and their removal from the synapse... - Metabotropic glutamate receptor-mediated long-term depression: molecular mechanismsClare M Gladding
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
Pharmacol Rev 61:395-412. 2009.... - A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinasesStephane Peineau
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
Mol Brain 2:22. 2009..Here we provide the first systematic investigation of the involvement of serine/threonine (ser/thr) protein kinases in NMDAR-LTD, using whole-cell recordings from CA1 pyramidal neurons... - Endocannabinoids: losing inhibition to increase learning capacity?Stephen M Fitzjohn
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, United Kingdom
Neuron 43:762-4. 2004.... - The Jak/STAT pathway is involved in synaptic plasticityCéline S Nicolas
MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK
Neuron 73:374-90. 2012..Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain...