Research Topics
| Edward J FeilSummaryAffiliation: University of Bath Country: UK Publications
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Publications
Small change: keeping pace with microevolutionEdward J Feil
Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
Nat Rev Microbiol 2:483-95. 2004- Evolutionary genetics of the accessory gene regulator (agr) locus in Staphylococcus aureusD Ashley Robinson
New York Medical College, Department of Microbiology and Immunology, Valhalla, NY 10595, USA
J Bacteriol 187:8312-21. 2005..aureus that horizontally transferred agr groups between two subspecies groups near the time that these subspecies groups diverged... - The phylogeny of Staphylococcus aureus - which genes make the best intra-species markers?Jessica E Cooper
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
Microbiology 152:1297-305. 2006..In the case of S. aureus this threshold is >1 % mean pairwise diversity... - Nonrandom distribution of Burkholderia pseudomallei clones in relation to geographical location and virulenceMongkol Vesaratchavest
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand, and Churchill Hospital, Oxford, UK
J Clin Microbiol 44:2553-7. 2006..This analysis reveals strong genetic differentiation on the basis of geographical isolation and a significant differentiation on the basis of virulence potential... - Protein evolution: causes of trends in amino-acid gain and lossLaurence D Hurst
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
Nature 442:E11-2; discussion E12. 2006..This reinforces the need for caution in the interpretation of results derived from closely related taxa... - The secret life of the multilocus sequence typeKatherine M E Turner
Department of Infectious Disease Epidemiology, Imperial College, St Mary s Hospital, Norfolk Place, London W2 1PG, UK
Int J Antimicrob Agents 29:129-35. 2007..aureus (MRSA) clones using MLST. We conclude with a speculative rationale for promoting the 'clonal complexes' of S. aureus to species status... - The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)Mark C Enright
Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
Proc Natl Acad Sci U S A 99:7687-92. 2002..aureus genotypes... - Emergence of a virulent clade of Vibrio vulnificus and correlation with the presence of a 33-kilobase genomic islandAna Luisa V Cohen
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Appl Environ Microbiol 73:5553-65. 2007..Our data suggest that lineage I may have a higher pathogenic potential and that region XII, along with other regions, may give isolates a selective advantage either in the human host or in the aquatic environment or both... - Searching for species in haloarchaeaR Thane Papke
Department of Molecular and Cell Biology, University of Connecticut, 91 North Eagleville Road, Storrs, CT 06269 3125, USA
Proc Natl Acad Sci U S A 104:14092-7. 2007..Arbitrary criteria might have limited practical use, but still must be agreed upon by the community... - The persistence of parasitic plasmidsLoukia N Lili
Department of Mathematical Sciences, University of Bath, BA2 7AY, Bath, United Kingdom
Genetics 177:399-405. 2007.... - Rapid detection of the pandemic methicillin-resistant Staphylococcus aureus clone ST 239, a dominant strain in Asian hospitalsEdward J Feil
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
J Clin Microbiol 46:1520-2. 2008..Results based on previously uncharacterized isolates from a hospital in northeast Thailand support the view that at least 90% of HA-MRSA isolates in mainland Asia correspond to ST 239 or close relatives... - The carriage population of Staphylococcus aureus from Mali is composed of a combination of pandemic clones and the divergent Panton-Valentine leukocidin-positive genotype ST152Raymond Ruimy
Hopital Bichat Claude Bernard, AP HP, EA 3964, Université Denis Diderot Paris 7 Medical School, 75870 Paris Cedex, France
J Bacteriol 190:3962-8. 2008..aureus clone noted mostly in Central Europe. We show that 100% of the ST152 isolates recovered from nasal carriage samples in Mali are PVL positive and discuss implications relating to the emergence and spread of this virulent genotype... - Comparisons of dN/dS are time dependent for closely related bacterial genomesEduardo P C Rocha
Atelier de BioInformatique, , 75005 Paris, France
J Theor Biol 239:226-35. 2006..We conclude that, because of the critical effect of time since divergence, inter-taxa comparisons are only possible by comparing trajectories of dN/dS over time and it is not valid to compare taxa on the basis of single time points... - Opinion: Re-evaluating prokaryotic speciesDirk Gevers
Laboratory of Microbiology and the Bioinformatics and Evolutionary Genomics Research Group, Ghent University VIB, Ghent, Belgium
Nat Rev Microbiol 3:733-9. 2005..We also consider the potential, and difficulties, of assigning species status to biologically or ecologically meaningful sequence clusters... - Determining the genetic structure of the natural population of Staphylococcus aureus: a comparison of multilocus sequence typing with pulsed-field gel electrophoresis, randomly amplified polymorphic DNA analysis, and phage typingHajo Grundmann
Division of Microbiology and Infectious Diseases, University Hospital Nottingham, Nottingham NG7 2UH, United Kingdom
J Clin Microbiol 40:4544-6. 2002..Only MLST was able to define clonal complexes unambiguously. All DNA-based typing approaches achieved a high degree of agreement, implying phylogenetic concordance, but predicted epidemiological associations with variable accuracy... - Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typingEmma Meats
Department of Infectious Disease Epidemiology, Imperial College London, St. Mary's Hospital, London W2 1PG, United Kingdom
J Clin Microbiol 41:1623-36. 2003..The H. influenzae MLST scheme is available at www.mlst.net, it allows any isolate to be compared with those in the MLST database, and (for encapsulated isolates) it assigns isolates to their phylogenetic lineage, via the Internet... - How clonal is Staphylococcus aureus?Edward J Feil
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
J Bacteriol 185:3307-16. 2003.... - High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzaeAlison J Cody
Molecular Infectious Diseases Group, Department of Paediatrics, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
Infect Genet Evol 3:57-66. 2003..These findings provide a population based foundation for a better understanding of the role of NTHi LPS as a virulence factor and its potential as a candidate vaccine... - eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing dataEdward J Feil
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
J Bacteriol 186:1518-30. 2004..pneumoniae and Staphylococcus aureus MLST databases, and the more complicated clonal complexes observed for Campylobacter jejuni and Neisseria meningitidis... - Analyses of clonality and the evolution of bacterial pathogensEdward J Feil
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
Curr Opin Microbiol 7:308-13. 2004.... - MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferiGabriele Margos
Departments of Biology and Biochemistry and Mathematical Sciences, University of Bath, Bath BA2 7AY, United Kingdom
Proc Natl Acad Sci U S A 105:8730-5. 2008..burgdorferi correspond to genetically distinct populations. Importantly, the MLST data suggest that B. burgdorferi originated in Europe rather than in North America as proposed previously... - Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistanceMatthew T G Holden
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
Proc Natl Acad Sci U S A 101:9786-91. 2004.... - Multilocus sequence typing--what is resolved?Jessica E Cooper
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
Trends Microbiol 12:373-7. 2004.... - Displaying the relatedness among isolates of bacterial species -- the eBURST approachBrian G Spratt
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Hospital, Old Medical School Building, London W2 1PG, UK
FEMS Microbiol Lett 241:129-34. 2004..We discuss the advantages of this approach and describe its use to explore patterns of descent within clonal complexes identified using multilocus sequence typing... - Burkholderia pseudomallei genome plasticity associated with genomic island variationSarinna Tumapa
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
BMC Genomics 9:190. 2008..pseudomallei isolates, little is known about the extent of variation between related strains or their association with disease or environmental survival... - Databases and software for the comparison of prokaryotic genomesDawn Field
Oxford Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
Microbiology 151:2125-32. 2005..This article reviews progress towards the development of computational tools and databases for organizing and extracting biological meaning from the comparison of large collections of genomes... - Multi-locus sequence typing of Bartonella henselae isolates from three continents reveals hypervirulent and feline-associated clonesMardjan Arvand
Institut fur Medizinische Mikrobiologie, Virologie und Hygiene, Universitat Rostock, Rostock, Germany
PLoS ONE 2:e1346. 2007..These data indicate that B. henselae lineages differ in their virulence properties for humans and contribute to a better understanding of the population structure of B. henselae... - S. aureus IgG-binding proteins SpA and Sbi: host specificity and mechanisms of immune complex formationKaren L Atkins
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
Mol Immunol 45:1600-11. 2008..The formation of insoluble immune complexes with Sbi occurs only via Fc binding and free Fc regions are unlikely to be available for Fc gamma R recognition and complement fixation... - The rise and fall of deleterious mutationKevin J Balbi
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
Res Microbiol 158:779-86. 2007..Here we review the impact of this effect by considering the gradual selective purging of deleterious mutation over time. We outline an approach to explore the dynamics of this process, and highlight its profound implications... - Similar compositional biases are caused by very different mutational effectsEduardo P C Rocha
Unité Génétique des Génomes Bactériens, URA 2171, Institut Pasteur, 75015 Paris, France
Genome Res 16:1537-47. 2006....