Research Topics
| Marco FalascaSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messengerMarco Falasca
Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK
Arch Physiol Biochem 112:274-84. 2006..In addition we describe the potential mechanism of switching on and off such signals. Taken together all this evidence suggest a novel, key role for PtdIns-3-P in signal transduction...- Role of class II phosphoinositide 3-kinase in cell signallingM Falasca
Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, Rayne Building, London, UK
Biochem Soc Trans 35:211-4. 2007..As a consequence, there is still relatively little understanding of the role of these enzymes and the question about the intracellular role of these isoforms still waits for more answers... - Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathwayEnza Piccolo
Department of Medicine, The Sackler Institute, University College London, 5, University Street, London WC1E 6JJ, UK
Oncogene 23:1754-65. 2004..These results support a role for Ins(1,3,4,5,6)P5 as a specific inhibitor of the PI 3-K/Akt signalling pathway, that may sensitize cancer cells to the action of commonly used anticancer drugs... - Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activationTania Maffucci
The Sackler Institute, University College London, 5 University Street, London WC1E 6JJ, UK
EMBO J 22:4178-89. 2003..These results give a new insight into the intracellular role of PtdIns-3-P and shed light on some aspects of insulin signalling so far not completely understood... - Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migrationTania Maffucci
Department of Medicine, The Sackler Institute, University College London, London WC1E 6JJ, England, UK
J Cell Biol 169:789-99. 2005..Defining this novel PI3K-C2beta-PtdIns-3-P signaling pathway may help clarify the process of cell migration and may shed new light on PI3K-mediated intracellular events... - Boyden chamberMarco Falasca
Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, London, UK
Methods Mol Biol 769:87-95. 2011..The method described in this chapter is intended specifically for measuring the migration or invasion of human endothelial and cancer cells... - The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migrationEnza Piccolo
Department of Oncology and Neuroscience, Section of Medical Oncology, Universita 'G. D'Annunzio, Via dei Vestini 1, 66100 Chieti, Italy
Oncogene 21:6520-9. 2002..This may suggest that influence of PI 3-K on PLCgamma1 could be relevant in cell migration, where PLCgamma1 seems to play a key role by modulating a series of events involved in actin polymerization... - Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effectsTania Maffucci
Department of Medicine, The Sackler Institute, University College London, United Kingdom
Cancer Res 65:8339-49. 2005..In this respect, Ins(1,3,4,5,6)P5, a water-soluble, natural compound with specific proapoptotic and antiangiogenic properties, might result in successful anticancer therapeutic strategies... - The role of phosphoinositide 3-kinase C2alpha in insulin signalingMarco Falasca
Inositide Signalling Group, Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London E1 2AT, United Kingdom
J Biol Chem 282:28226-36. 2007....