Research Topics
Species | Margaret EsiriSummaryAffiliation: University of Oxford Country: UK Publications
| Collaborators
|
Detail Information
Publications
Vulnerability to Alzheimer's pathology in neocortex: the roles of plasticity and columnar organizationM M Esiri
Department of Clinical Neurology, University of Oxford, Oxford, UK
J Alzheimers Dis 9:79-89. 2006..The original interpretation that this distribution of NFT reflects pathology in neurons subserving cortico-cortical and cortico-subcortical connections seems to us to have stood the test of time...- Immunohistochemical study of N-epsilon-carboxymethyl lysine (CML) in human brain: relation to vascular dementiaLouise Southern
Department of Clinical Neurology, University of Oxford, West Wing, John Radcliffe Hospital, Oxford UK
BMC Neurol 7:35. 2007..We tested if, among people with cerebrovascular disease, (1) those with dementia have higher levels of neuronal and vascular AGEs and (2) if cognitive dysfunction depends on neuronal and/or vascular AGE levels... - IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brainJohn S Tzartos
Department of Neuropathology, Weatherall Institute of Molecular Medicine, Oxford Radcliffe NHS Trust, Oxford, United Kingdom
Am J Pathol 178:794-802. 2011..These findings suggest role(s) for IL-21 in both the acute and chronic stages of MS via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons... - Pro: Can neuropathology really confirm the exact diagnosis?Margaret M Esiri
Neuropathology Dept, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
Alzheimers Res Ther 2:10. 2010..Human studies are also needed to explore the changes in pathology that new treatments for AD may produce... - MS: Is it One Disease?Margaret Esiri
Neuropathology Department, Level 1, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK Phone 44 0 1865 234403 Fax 44 0 1865 231157 E mail
Int MS J 16:39-41. 2009.... - The interplay between inflammation and neurodegeneration in CNS diseaseMargaret M Esiri
Department of Clinical Neurology, University of Oxford, UK Department of Neuropathology, Oxford Radcliffe NHS Trust, UK
J Neuroimmunol 184:4-16. 2007..Common themes as well as disease-specific differences are highlighted in this survey of the recent human disease and animal model literature... - Prion protein immunoreactivity in brain samples from an unselected autopsy population: findings in 200 consecutive casesM M Esiri
Departments of Neuropathology and Clinical Neurology, Radcliffe Infirmary, Oxford, UK
Neuropathol Appl Neurobiol 26:273-84. 2000..They may indicate that cellular PrP is increased in the human brain under some circumstances and provide insight into the handling of this protein by human brain cells... - Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal modelSandra Vergo
Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
Brain 134:571-84. 2011..Together these findings suggest that blockade of acid-sensing ion channel 1 has the potential to provide both neuro- and myelo-protective benefits in multiple sclerosis... - Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosisIan M Pomeroy
Department of Neuropathology, Radcliffe Infirmary, Oxford, UK
Brain 128:2713-21. 2005..We believe that this tool can be exploited in future studies to investigate the aetiology, development and clinical significance of cortical lesions in demyelinating disease... - Ventricular enlargement in schizophrenia: a primary change in the temporal lobe?Steven A Chance
University of Oxford, Oxford, UK
Schizophr Res 62:123-31. 2003..The anatomical origin of the enlargement of the cerebral ventricles in schizophrenia is obscure... - Amygdala volume in schizophrenia: post-mortem study and review of magnetic resonance imaging findingsSteven A Chance
University of Oxford, UK
Br J Psychiatry 180:331-8. 2002..Some post-mortem studies do not find these abnormalities... - Axonal injury in cerebral malariaIsabelle M Medana
Nuffield Departments of Clinical Laboratory Sciences and Medicine, Level 5 Lab R 5501, The John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, United Kingdom
Am J Pathol 160:655-66. 2002..falciparum malaria infection. Disruption in axonal transport may represent a final common pathway leading to neurological dysfunction in cerebral malaria... - Minicolumn thinning in temporal lobe association cortex but not primary auditory cortex in normal human ageingSteven A Chance
Department of Neuropathology, Radcliffe Infirmary, Woodstock Road, OX2 6HE, Oxford, UK
Acta Neuropathol 111:459-64. 2006..Since old age is the greatest risk factor for dementia, the transition to dementia may involve an extension of normal ageing processes... - Diffuse cortical atrophy in a marmoset model of multiple sclerosisIan M Pomeroy
Department of Clinical Neurology, University of Oxford, Oxford, UK
Neurosci Lett 437:121-4. 2008..Marmoset EAE is an invaluable tool which can be used to further investigate the cause and the substrate of cortical loss in demyelinating diseases... - Macroscopic brain asymmetry is changed along the antero-posterior axis in schizophreniaSteven A Chance
Schizophrenia Research, Neuropathology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
Schizophr Res 74:163-70. 2005..Anatomical asymmetry may be altered in schizophrenia, but the changes are subtle and in some studies undetected perhaps due to methodological limitations... - Asymmetry of the uncinate fasciculus: a post-mortem study of normal subjects and patients with schizophreniaJ Robin Highley
Schizophrenia Research Group, Department of Clinical Neurology (Neuropathology, Radcliffe Infirmary, Oxford, UK
Cereb Cortex 12:1218-24. 2002..The unchanged size of the fasciculus in schizophrenia contrasts with commissural tracts, which are affected in this brain series in a sex-specific manner... - Protein co-expression with axonal injury in multiple sclerosis plaquesMaria Diaz-Sanchez
Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, OX2 6HE, Oxford, UK
Acta Neuropathol (Berl) 111:289-99. 2006.... - Ischemic stroke in the elderly: an overview of evidenceRuo Li Chen
Nuffield Department of Medicine, University of Oxford, Headington, Oxford, UK
Nat Rev Neurol 6:256-65. 2010.... - Low medial and lateral right pulvinar volumes in schizophrenia: a postmortem studyJ Robin Highley
University Department of Psychaitry, Warneford Hospital, Oxford, UK
Am J Psychiatry 160:1177-9. 2003..The lateralized findings may reflect pulvinar connections with asymmetrical neocortical regions and their asymmetrical involvement in schizophrenia... - Estimated neuronal populations and volumes of the hippocampus and its subfields in schizophreniaMary A Walker
Department of Neuropathology, Radcliffe Infirmary, Oxford, UK
Am J Psychiatry 159:821-8. 2002..No significant differences were observed between patients and comparison subjects in the cellular composition of the hippocampus. CONCLUSIONS: These findings do not support a primary alteration of the hippocampus in schizophrenia... - T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptidesMaria Harkiolaki
Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
Immunity 30:348-57. 2009..Thus, these data suggest a possible explanation for the difficulty in incriminating individual infections in the development of MS... - Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosisJohn S Tzartos
Department of Neuropathology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
Am J Pathol 172:146-55. 2008.... - Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathologyMitchell K P Lai
Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore
J Neural Transm 115:1165-72. 2008.... - Noradrenergic changes, aggressive behavior, and cognition in patients with dementiaKim L Matthews
Dementia Research Laboratory, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King's College, London, UK
Biol Psychiatry 51:407-16. 2002..Therefore, this study may have implications for the treatment of behavioral and psychiatric signs and symptoms in dementia, particularly aggressive behavior in patients with dementia... - Alpha-synuclein pathology in the olfactory pathways of dementia patientsPaul S Hubbard
Division of Neuroscience, The Medical School, University of Birmingham, UK
J Anat 211:117-24. 2007..Furthermore, the results presented here provide further evidence supporting the possible value of a smell test to aid the clinical diagnosis of neurodegenerative diseases... - Postmortem serotoninergic correlates of cognitive decline in Alzheimer's diseaseMitchell K P Lai
Department of Pharmacology, University of Sydney, NSW 2006, Australia
Neuroreport 13:1175-8. 2002..Our study suggests that reduced serotonin levels and increased serotonin1A receptor density are markers for accelerated cognitive decline in AD, and provides support for the use of serotonin1A antagonists in the treatment of AD... - Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patientsShirley W Y Tsang
Neurodegenerative Diseases Program, National Neuroscience Institute, Singapore 169608
Neuroreport 14:1297-300. 2003..Since serotonin-synthesizing neurons are known to be lost in the AD cortex, this study suggests that the preservation of 5-HTT may exacerbate serotonergic deficits and underlie anxiety symptoms in AD... - Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's diseaseShirley W Y Tsang
Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore
Neurobiol Aging 27:1216-23. 2006..Based on its associations with ChAT deficits and dementia severity, we propose that M1/G-protein uncoupling may have a significant role in the disease mechanism of AD and thus may be considered to be a potential therapeutic target... - Spinal cord atrophy in multiple sclerosis caused by white matter volume lossChristopher P Gilmore
Department of Neurology, Queens Medical Centre National Health Service Trust, Nottingham, England
Arch Neurol 62:1859-62. 2005..To assess the relative contributions of white matter (WM) and gray matter (GM) volume loss to spinal cord atrophy in multiple sclerosis (MS)... - Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's diseaseMitchell K P Lai
Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
Neurobiol Dis 22:555-61. 2006..This study suggests that APOE epsilon4 selectively affects presynaptic cholinergic function which may contribute to the clinical and neuropathological features of AD... - Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer diseaseMitchell K P Lai
Department of Clinical Research, Singapore General Hospital, Singapore
Brain Res 974:82-7. 2003..Our data indicate further study of 5-HT(1A) receptors as a pharmacological target for the treatment of behavioral symptoms in AD... - Spinal cord gray matter demyelination in multiple sclerosis-a novel pattern of residual plaque morphologyChristopher P Gilmore
Department of Neurology, Queens Medical Centre NHS Trust, Nottingham, UK
Brain Pathol 16:202-8. 2006..Myelin protein IHC reveals a novel pattern of residual plaque morphology challenging previous work suggesting that MS plaques display a total disregard for anatomical boundaries... - Anomalies of asymmetry of pyramidal cell density and structure in dorsolateral prefrontal cortex in schizophreniaThomas J Cullen
Prince of Wales International Centre for SANE Research, Warneford Hospital, Oxford OX3 7JX, UK
Br J Psychiatry 188:26-31. 2006.... - Pathological validation of a CT-based scale for subcortical vascular disease. The OPTIMA StudyRoberta Rossi
Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
Dement Geriatr Cogn Disord 19:61-6. 2005..This supports the validity of the CT-based visual rating scale as a valid tool to detect subcortical vascular changes in elderly persons... - Association between subcortical vascular disease on CT and neuropathological findingsRoberta Rossi
Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
Int J Geriatr Psychiatry 19:690-5. 2004..05). CONCLUSION: The standardized assessment of svCVD on CT films at the time of the diagnosis correlates with small vessel disease on pathology at death... - Molecular pathology shows p16 methylation in nonadenomatous pituitaries from patients with Cushing's diseaseDavid J Simpson
Institute of Science and Technology in Medicine, School of Medicine, Keele University, Stoke on Trent, Staffordshire, United Kingdom
Clin Cancer Res 10:1780-8. 2004..In this study we have used molecular pathology to determine whether the tissue labeled histologically as "normal" is indeed abnormal...