J S Duffield

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Activated macrophages direct apoptosis and suppress mitosis of mesangial cells
    J S Duffield
    Centre for Inflammation Research, Department of Clinical Sciences, Royal Infirmary, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 164:2110-9. 2000
  2. ncbi Suppression by apoptotic cells defines tumor necrosis factor-mediated induction of glomerular mesangial cell apoptosis by activated macrophages
    J S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Am J Pathol 159:1397-404. 2001
  3. ncbi The inflammatory macrophage: a story of Jekyll and Hyde
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Clin Sci (Lond) 104:27-38. 2003
  4. ncbi Low-dose cyclosporin therapy for recombinant erythropoietin-induced pure red-cell aplasia
    Jeremy S Duffield
    Department of Renal Medicine, Royal Infirmary, Lauriston Place, Edinburgh, UK
    Nephrol Dial Transplant 19:479-81. 2004
  5. ncbi Quantitative morphometry of lupus nephritis: the significance of collagen, tubular space, and inflammatory infiltrate
    Michael G Hunter
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Kidney Int 67:94-102. 2005
  6. ncbi Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
  7. ncbi Conditional ablation of macrophages halts progression of crescentic glomerulonephritis
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research Medical School, University of Edinburgh, UK, and the Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 167:1207-19. 2005
  8. ncbi Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
    Jonathan A Fallowfield
    Liver Research Group, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 178:5288-95. 2007
  9. ncbi Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
    Takaharu Ichimura
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1657-68. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Activated macrophages direct apoptosis and suppress mitosis of mesangial cells
    J S Duffield
    Centre for Inflammation Research, Department of Clinical Sciences, Royal Infirmary, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 164:2110-9. 2000
    ..These data demonstrate that activated macrophages, via the release of NO and other mediators, regulate mesangial cell populations in vitro and may therefore control the mesangial cell complement at inflamed sites...
  2. ncbi Suppression by apoptotic cells defines tumor necrosis factor-mediated induction of glomerular mesangial cell apoptosis by activated macrophages
    J S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Am J Pathol 159:1397-404. 2001
    ....
  3. ncbi The inflammatory macrophage: a story of Jekyll and Hyde
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Clin Sci (Lond) 104:27-38. 2003
    ..Recent insights into the mechanisms by which apoptotic cells signal the change of function to the Mphi offer the prospect of novel targets for manipulation of Mphis in the inflamed tissue...
  4. ncbi Low-dose cyclosporin therapy for recombinant erythropoietin-induced pure red-cell aplasia
    Jeremy S Duffield
    Department of Renal Medicine, Royal Infirmary, Lauriston Place, Edinburgh, UK
    Nephrol Dial Transplant 19:479-81. 2004
  5. ncbi Quantitative morphometry of lupus nephritis: the significance of collagen, tubular space, and inflammatory infiltrate
    Michael G Hunter
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Kidney Int 67:94-102. 2005
    ..CONCLUSION: A simple automated system for objectively scoring biopsies of lupus nephritis predicts renal survival and may provide a useful adjunct to guide patient management...
  6. ncbi Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
    ..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring...
  7. ncbi Conditional ablation of macrophages halts progression of crescentic glomerulonephritis
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research Medical School, University of Edinburgh, UK, and the Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 167:1207-19. 2005
    ..This study demonstrates that macrophages are key effectors of disease progression in crescentic GN, acting to regulate parenchymal cell populations by modulating both cell proliferation and apoptosis...
  8. ncbi Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
    Jonathan A Fallowfield
    Liver Research Group, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 178:5288-95. 2007
    ..Thus, SAMs selectively, during resolution of fibrosis induce and use the major collagenase MMP13 to mediate the resorption of interstitial matrix and successfully remodel the fibrotic liver...
  9. ncbi Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
    Takaharu Ichimura
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1657-68. 2008
    ..Thus, KIM-1 is the first nonmyeloid phosphatidylserine receptor identified to our knowledge that transforms epithelial cells into semiprofessional phagocytes...