Research Topics
Genomes and Genes | K DrickamerSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Polymorphisms in human langerin affect stability and sugar binding activityEliot M Ward
Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
J Biol Chem 281:15450-6. 2006..These findings suggest that certain langerin haplotypes may differ in their binding to pathogens and thus might be associated with susceptibility to infection...- C-type lectin-like domainsK Drickamer
Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
Curr Opin Struct Biol 9:585-90. 1999..C-type lectin-like domains associate with each other through several different surfaces to form dimers and trimers, from which ligand-binding sites project in a variety of different orientations... - Making a fitting choice: common aspects of sugar-binding sites in plant and animal lectinsK Drickamer
Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
Structure 5:465-8. 1997..In the context of this combination of convergent and divergent evolution, our knowledge of the structures of lectin-sugar complexes provides valuable insights into the principles that underlie specific sugar binding... - Evolving views of protein glycosylationK Drickamer
Dept of Biochemistry, University of Oxford, UK
Trends Biochem Sci 23:321-4. 1998..The evolution of glycoprotein biosynthesis and recognition mechanisms can be best understood as a sequential development of functions associated with oligosaccharides... - Glycan arrays for functional glycomicsKurt Drickamer
Glycobiology Institute, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK
Genome Biol 3:REVIEWS1034. 2002..Two recent papers describe how arrays of oligosaccharide and polysaccharide molecules can be used to investigate these interactions more fully... - A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligandsD A Mitchell
Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
J Biol Chem 276:28939-45. 2001..Binding to clustered oligosaccharides may also explain the interaction of these receptors with the gp120 envelope protein of human immunodeficiency virus-1, which contributes to virus infection... - Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activityR B Dodd
Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Glycobiology 11:71R-9R. 2001.... - Minimal requirements for the binding of selectin ligands to a C-type carbohydrate-recognition domainS Bouyain
Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
Glycobiology 11:989-96. 2001.... - Asymmetry adjacent to the collagen-like domain in rat liver mannose-binding proteinR Wallis
Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U K
Biochem J 325:391-400. 1997..The relatively simple organization of MBP-C provides a template for understanding larger, more complex collectins... - Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligandsPeter J Coombs
Glycobiology Institute, Department of Biochemistry, University of Oxford, UK
J Biol Chem 280:22993-9. 2005..These studies suggest that SRCL might be involved in selective clearance of specific desialylated glycoproteins from circulation and/or interaction of cells bearing Lewis(x)-type structures with the vascular endothelium... - Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteinsHadar Feinberg
Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 282:4202-9. 2007.... - Two categories of mammalian galactose-binding receptors distinguished by glycan array profilingPeter J Coombs
Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
Glycobiology 16:1C-7C. 2006.... - All but the shortest polymorphic forms of the viral receptor DC-SIGNR assemble into stable homo- and heterotetramersYuan Guo
Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom
J Biol Chem 281:16794-8. 2006..The heterotetramers are stable and can be detected in fibroblasts transfected with multiple forms of DC-SIGNR. These results provide a molecular basis for interpreting the way polymorphisms affect interactions with viruses... - A focused microarray approach to functional glycomics: transcriptional regulation of the glycomeElena M Comelli
Department of Molecular Biology and Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Glycobiology 16:117-31. 2006..The glycogene chip reported in this study is available to the scientific community through the Consortium for Functional Glycomics (CFG) (http://www.functionalglycomics.org)... - Paradigms for glycan-binding receptors in cell adhesionMaureen E Taylor
Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom
Curr Opin Cell Biol 19:572-7. 2007..Instead, glycans and receptor-glycan interactions often modulate adhesion in indirect ways, such as by changing the organisation of cell surface glycoproteins and by antagonising the effect of protein adhesion systems... - Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNRYuan Guo
Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
Nat Struct Mol Biol 11:591-8. 2004..Thus, whereas DC-SIGN has dual ligand-binding properties and functions both in adhesion and in endocytosis of pathogens, DC-SIGNR binds a restricted set of ligands and has only the properties of an adhesion receptor... - Localization of the serine protease-binding sites in the collagen-like domain of mannose-binding protein: indirect effects of naturally occurring mutations on protease binding and activationRussell Wallis
Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
J Biol Chem 279:14065-73. 2004..Thus, the effect of the mutations is to destabilize the collagen-like domain, indirectly disrupting the binding sites for MASPs. In addition, at least one of the mutations has a further effect on the ability of MBP to activate MASPs... - Identification of lectins from genomic sequence dataKurt Drickamer
Department of Biochemistry, Glycobiology Institute, University of Oxford, South Parks Road, Oxford 0X1 3QU, United Kingdom
Methods Enzymol 362:560-7. 2003 - Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2Hadar Feinberg
Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Drive West, CA 94305 5126, USA
EMBO J 22:2348-59. 2003..A model of the full six-domain structure and its interaction with MBPs suggests mechanisms by which binding to a target cell transmits conformational changes from MBP to MASP that allow activation of its protease activity... - Oligolysine-based oligosaccharide clusters: selective recognition and endocytosis by the mannose receptor and dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrinNatacha Frison
Glycobiologie-Vectorologie et Trafic Intracellulaire, , CNRS, rue Charles-Sadron, , France
J Biol Chem 278:23922-9. 2003..The results suggest that ligands containing dimannoside clusters can be used specifically to target the mannose receptor, whereas ligands containing Lewis clusters will be targeted to DC-SIGN... - Molecular characterization of the rat Kupffer cell glycoprotein receptorAndrew J Fadden
The Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX21 3QU, United Kingdom
Glycobiology 13:529-37. 2003..These characteristics suggest that the receptor may have functions parallel to those of the hepatocyte asialoglycoprotein receptor in some (but not all) mammalian species... - An endogenous Drosophila receptor for glycans bearing alpha 1,3-linked core fucose residuesSamuel Bouyain
Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
J Biol Chem 277:22566-72. 2002..CG2958 is a potential endogenous receptor for such neural-specific carbohydrate epitopes... - Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognitionKenneth K-S Ng
Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 277:16088-95. 2002..A lateral association of trimers in the cross-linked crystals may reflect interactions within higher oligomers of MBP-A that are stabilized by multivalent ligands... - A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycansAlex S Powlesland
Division of Molecular Biosciences, Imperial College, London, United Kingdom
J Biol Chem 283:593-602. 2008..Thus, multiple receptors interact with surface glycoproteins of enveloped viruses that bear different types of relatively poorly processed glycans...