Research Topics
| Anne D DonaldsonSummaryAffiliation: University of Aberdeen Country: UK Publications
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Detail Information
Publications
Shaping time: chromatin structure and the DNA replication programmeAnne D Donaldson
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Trends Genet 21:444-9. 2005..In this article, I assess the impact of recent investigations and compare our knowledge of DNA replication-timing controls in yeast with those of metazoans...
The effect of Ku on telomere replication time is mediated by telomere length but is independent of histone tail acetylationHui Yong Lian
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Mol Biol Cell 22:1753-65. 2011....
Early initiation of a replication origin tethered at the nuclear peripheryHani Ebrahimi
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
J Cell Sci 123:1015-9. 2010..Overall, our results demonstrate that a replication origin can initiate replication early in S phase, even if artificially relocated to the nuclear periphery...
Histone H3 lysine 56 acetylation by Rtt109 is crucial for chromosome positioningShin Ichiro Hiraga
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
J Cell Biol 183:641-51. 2008..Because chromosome positioning is subject to epigenetic inheritance, H3K56 acetylation may mediate correct chromosome localization by facilitating accurate transmission of chromatin status during DNA replication...
Quantitative proteomic analysis of chromatin reveals that Ctf18 acts in the DNA replication checkpointTakashi Kubota
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Mol Cell Proteomics 10:M110.005561. 2011..Identification of Ctf18 as a checkpoint protein highlights the usefulness of chromatin proteomic analysis for understanding the in vivo function of proteins that mediate chromatin transactions...
Release of yeast telomeres from the nuclear periphery is triggered by replication and maintained by suppression of Ku-mediated anchoringHani Ebrahimi
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom
Genes Dev 22:3363-74. 2008..In addition to maintaining genetic information, DNA replication may therefore regulate subnuclear organization of chromatin...
OriDB: a DNA replication origin databaseConrad A Nieduszynski
Institute of Medical Science, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Nucleic Acids Res 35:D40-6. 2007..Finally, a Chromosome Viewer utility allows users to interactively generate graphical representations of DNA replication data genome-wide. OriDB is available at www.oridb.org...
The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication timeShin Ichiro Hiraga
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
EMBO J 25:1505-14. 2006..Our results suggest that the Ctf18 RFC-like complex modifies telomeric chromatin to make it competent for normal localization to the nuclear periphery...
Genome-wide identification of replication origins in yeast by comparative genomicsConrad A Nieduszynski
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
Genes Dev 20:1874-9. 2006..Our results demonstrate that phylogenetic conservation can be used to identify the origin sequences responsible for replicating a eukaryotic genome...
The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcriptionConrad A Nieduszynski
Institute of Medical Sciences, University of Aberdeen Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Nucleic Acids Res 33:2410-20. 2005..This hierarchy is both 'hard-wired' by the minimal origin sequences and 'soft-wired' by local transcriptional context...
DNA replication: telling time with microarraysHeather J McCune
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Genome Biol 4:204. 2003..But do contrasting results from yeast and a recent study in Drosophila imply that replication timing and transcriptional activity are differentially regulated in yeast and higher eukaryotes?..
Ku complex controls the replication time of DNA in telomere regionsAndrew J Cosgrove
Cancer Research UK Chromosome Replication Research Group, Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
Genes Dev 16:2485-90. 2002..Ku is one of the first components identified as important for replication timing, and specification of the replication time of chromosome ends by Ku is consistent with its role in maintaining telomere localization...
