Heather Davidson

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Genomic sequence analysis of Fugu rubripes CFTR and flanking genes in a 60 kb region conserving synteny with 800 kb of human chromosome 7
    H Davidson
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Genome Res 10:1194-203. 2000
  2. ncbi Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways
    Heather Davidson
    Medical Sciences Medical Genetics, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Am J Respir Cell Mol Biol 35:72-83. 2006
  3. ncbi An immunocytochemical assay to detect human CFTR expression following gene transfer
    Heather Davidson
    Medical Genetics, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH42XU, UK
    Mol Cell Probes 23:272-80. 2009
  4. ncbi Differential global gene expression in cystic fibrosis nasal and bronchial epithelium
    Varrie Ogilvie
    Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, UK
    Genomics 98:327-36. 2011
  5. ncbi Antibodies for CFTR studies
    Filipa Mendes
    Center of Human Genetics, National Institute of Health Dr. Ricardo Jorge, Lisboa, Portugal
    J Cyst Fibros 3:69-72. 2004
  6. ncbi Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators
    Felix Munkonge
    Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 GLR, UK
    J Cyst Fibros 3:171-6. 2004
  7. ncbi Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR
    Toby S Scott-Ward
    Department of Physiology and Pharmacology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    Proc Natl Acad Sci U S A 104:16365-70. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Genomic sequence analysis of Fugu rubripes CFTR and flanking genes in a 60 kb region conserving synteny with 800 kb of human chromosome 7
    H Davidson
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Genome Res 10:1194-203. 2000
    ..The euryhaline killifish CFTR coding sequence is highly homologous to the Fugu sequence, suggesting that upregulation of CFTR in that species in response to salinity may be regulated transcriptionally...
  2. ncbi Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways
    Heather Davidson
    Medical Sciences Medical Genetics, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Am J Respir Cell Mol Biol 35:72-83. 2006
    ..The strategic use of hCFTR-specific antibodies supports the utility of the normal sheep as a model for hCFTR gene transfer studies...
  3. ncbi An immunocytochemical assay to detect human CFTR expression following gene transfer
    Heather Davidson
    Medical Genetics, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH42XU, UK
    Mol Cell Probes 23:272-80. 2009
    ..Our aim was to develop a reproducible immunocytochemical assay for human CFTR protein which can measure both endogenous CFTR levels and augmented CFTR expression after gene delivery...
  4. ncbi Differential global gene expression in cystic fibrosis nasal and bronchial epithelium
    Varrie Ogilvie
    Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, UK
    Genomics 98:327-36. 2011
    ..We conclude that CF and non-CF nasal and bronchial epithelium are transcriptionally distinct and CF nasal epithelium is not a good surrogate for the lung respiratory epithelium...
  5. ncbi Antibodies for CFTR studies
    Filipa Mendes
    Center of Human Genetics, National Institute of Health Dr. Ricardo Jorge, Lisboa, Portugal
    J Cyst Fibros 3:69-72. 2004
    ..Here, we review the applicability of most Abs currently in use in CF research for the biochemical and/or immunocytochemical detection of CFTR...
  6. ncbi Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators
    Felix Munkonge
    Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 GLR, UK
    J Cyst Fibros 3:171-6. 2004
    ..These fluorescence methods permit the quantitative analysis of CFTR function...
  7. ncbi Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR
    Toby S Scott-Ward
    Department of Physiology and Pharmacology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    Proc Natl Acad Sci U S A 104:16365-70. 2007
    ..We conclude that the NBDs of murine CFTR determine the unique gating behavior of its subconductance state, whereas NBD2 controls channel potentiation by PP(i)...