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Genomes and GenesSpecies | Russell C DaleSummaryAffiliation: University College London Country: UK Publications
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Publications
Interleukin-6 and oligoclonal IgG synthesis in children with acute disseminated encephalomyelitisR C Dale
Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
Neuropediatrics 34:141-5. 2003..05). These results would suggest a role for IL-6 in the pathology of ADEM, and a possible direct link between an increased IL-6 and a proliferation of B lymphocytes with consequent IgG production...- [Streptococcus pyogenes and the brain: living with the enemy]R C Dale
Neurosciences Unit, Institute of Child Health, University College Londres, Reino Unido
Rev Neurol 37:92-7. 2003..This represents a possible model of immunological mimicry and its potential importance with respect to certain idiopathic disorders such as Tourette syndrome and obsessive compulsive disorder... - Autoimmunity and the basal ganglia: new insights into old diseasesR C Dale
Neurosciences Unit, Institute of Child Health, London, UK
QJM 96:183-91. 2003.... - Acute disseminated encephalomyelitisRussell C Dale
Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, and the Department of Neuroinflammation, Institute of Neurology, London, United Kingdom
Semin Pediatr Infect Dis 14:90-5. 2003..In view of the treatment differences between ADEM and viral encephalitis, being familiar with ADEM is essential for pediatricians managing acute neurological disorders... - Post-streptococcal autoimmune dystonia with isolated bilateral striatal necrosisRussell C Dale
Neurosciences Unit, Institute of Child Health, London, UK
Dev Med Child Neurol 44:485-9. 2002..Acute IBSN is part of the poststreptococcal autoimmune neuropsychiatric spectrum. An autoimmune aetiology should be considered in this phenotype, as immunomodulatory therapies may reduce morbidity and mortality... - Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunityRussell C Dale
Neurosciences Unit, Great Ormond Street Hospital and Institute of Child Health, and Department of Neuroinflammation, Institute of Neurology, University College London, UK
Brain 127:21-33. 2004..We believe an EL-like syndrome is still prevalent, and propose that this syndrome may be secondary to autoimmunity against deep grey matter neurons... - Striatal encephalitis after varicella zoster infection complicated by TourettismRussell C Dale
Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, United Kingdom
Mov Disord 18:1554-6. 2003..The patient subsequently developed a chronic tic disorder with attention deficit disorder. This case furthers the proposed association between Tourettism and the basal ganglia... - Dyskinesias and associated psychiatric disorders following streptococcal infectionsR C Dale
Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
Arch Dis Child 89:604-10. 2004..Recently, other post-streptococcal movement disorders have been described, including motor tics and dystonia. Associated emotional and behavioural alteration is characteristic... - Acute disseminated encephalomyelitis or multiple sclerosis: can the initial presentation help in establishing a correct diagnosis?R C Dale
Great Ormond Street Hospital NHS Trust and Institute of Child Health, London, UK
Arch Dis Child 90:636-9. 2005..When there are relapses or progressive disease, the term multiple sclerosis (MS) is used (for full recommended diagnostic criteria for multiple sclerosis refer to McDonald and colleagues)... - Childhood opsoclonus myoclonusRussell C Dale
Neurosciences Unit, Institute of Child Health, University College, London, UK
Lancet Neurol 2:270. 2003 - Post-streptococcal autoimmune neuropsychiatric disease presenting as paroxysmal dystonic choreoathetosisRussell C Dale
Department of Neurology, Great Ormond Street Hospital NHS Trust and Institute of Child Health, London, United Kingdom
Mov Disord 17:817-20. 2002..We propose that autoantibodies produced in post-streptococcal neuropsychiatric disease cause alteration in neurotransmission, possibly secondary to ion channel binding... - CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?Andrew J Church
Neuroimmunology Unit, Neuroinflammation Department, Institute of Neurology, Room 917, Queen Square, London WC1N 3BG, UK
J Neuroimmunol 136:149-53. 2003..OCB were found in 46% of acute SC, ABGA were in 93% of acute SC and 50% of persistent SC was of IgG(1) and IgG(3) subclass. These findings support an autoantibody pathogenesis... - Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS diseaseRussell C Dale
Department of Neuroinflammmation, Institute of Neurology, University College London, and Neurosciences Unit, Great Ormond Street Hospital and Institute of Child Health, London WC1N 3JJ, UK
J Neuroimmunol 172:187-97. 2006..GAS also expresses glycolytic enzymes on cell surfaces that have 0-49% identity with human NGE, suggesting molecular mimicry and autoimmune cross-reactivity may be the pathogenic mechanism in post-streptococcal CNS disease... - Antineuronal antibody status and phenotype analysis in Tourette's syndromeDavide Martino
Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 22:1424-9. 2007..14; P = 0.002; 95% confidence interval 0.04-0.49). ANeA status does not differentiate a specific phenotype of GTS... - Post-streptococcal autoimmune disorders of the central nervous systemRussell C Dale
Neurosciences Unit, Great Ormond Street Hospital NHS Trust, London, UK
Dev Med Child Neurol 47:785-91. 2005..However, post-streptococcal disorders of the CNS remain a useful model of neuropsychiatric disease, which may improve our understanding of abnormal movements and behaviours in children... - Adult-onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodiesMark J Edwards
Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, United Kingdom
Mov Disord 19:1190-6. 2004..We suggest that there might be a causal relationship between ABGA and the clinical syndrome in these cases and that ABGA should be considered as a possible etiology for adult-onset tics... - Quantitative demonstration of intrathecal synthesis of high affinity immunoglobulin G in herpes simplex encephalitis using affinity-mediated immunoblottingMiles D Chapman
Department of Neuroimmunology, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Neuroimmunol 185:130-5. 2007..Digitisation of the blots enabled further analysis. We showed that the clones of antigen-specific IgG, which were produced intrathecally, were of higher relative affinity than polyclonal antigen-specific IgG... - Soluble adhesion molecules in Gilles de la Tourette's syndromeD Martino
Neuroimmunology Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
J Neurol Sci 234:79-85. 2005..These results provide initial evidence for a role of adhesion molecules and systemic inflammation in TS, and support the hypothesis of an ongoing immune-mediated process in this condition... - A dystonic syndrome associated with anti-basal ganglia antibodiesM J Edwards
Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 75:914-6. 2004..It is hypothesised that dystonia in adults or adolescents may be part of the clinical spectrum of the post-infectious syndrome associated with ABGA... - Soluble adhesion molecules in acute disseminated encephalomyelitisDavide Martino
Department of Neuroinflammation, Institute of Neurology, University College London, UK
Pediatr Neurol 33:255-8. 2005..Further larger studies are required including serial measurements and cerebrospinal fluid analysis... - Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesisA J Church
Neuroinflammation Department, Institute of Neurology, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 74:602-7. 2003..Anti-basal ganglia antibodies (ABGA) are present in most cases of acute Sydenham's chorea, but rarely in controls... - Anti-basal ganglia antibodies: a possible diagnostic utility in idiopathic movement disorders?A J Church
Neuroinflammation Department, Institute of Neurology, Queen Square, London, UK WC1N 3BG
Arch Dis Child 89:611-4. 2004..The spectrum of post-streptococcal brain disorders includes chorea, tics, and dystonia. The proposed mediators of disease are anti-basal ganglia (neuronal) antibodies (ABGA)... - Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodiesP M Candler
Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 77:507-12. 2006..Adult opsoclonus-myoclonus (OM), a disorder of eye movements accompanied by myoclonus affecting the trunk, limbs, or head, is commonly associated with an underlying malignancy or precipitated by viral infection... - Anti-basal ganglia antibodies in acute and persistent Sydenham's choreaA J Church
Neuroimmunology Unit, Neuroinflammation Department, Institute of Neurology, Queen Square, London, UK
Neurology 59:227-31. 2002..To determine the sensitivity and specificity of methods to detect anti-basal ganglia antibodies (ABGA) in Sydenham's chorea (SC)... - Anti-basal ganglia antibodies in patients with atypical dystonia and tics: a prospective studyM J Edwards
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, UK
Neurology 63:156-8. 2004..An autoimmune mechanism may underlie a proportion of cases of atypical movement disorders... - Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in childrenR C Dale
Departments of Neurology, Radiology and Histopathology, Great Ormond Street Hospital for Children and Institute of Child Health, University College London, London, UK
Brain 123:2407-22. 2000..These differences in the presentation of ADEM/MDEM compared with multiple sclerosis may help in the prognosis given to families regarding the possibility of later development of multiple sclerosis... - Three cases of central nervous system complications associated with Mycoplasma pneumoniaePaul M Candler
Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
Pediatr Neurol 31:133-8. 2004..Systematic investigation to discriminate between these two processes will be essential to select appropriate antibiotic and immunomodulatory therapies... - Tracing Sydenham's chorea: historical documents from a British paediatric hospitalD Martino
Department of Neuroinflammation, Institute of Neurology, University College Medical School, London, UK
Arch Dis Child 90:507-11. 2005.... - Immune mediated chorea encephalopathy syndrome in childhoodL M Hartley
Department of Neurology, Great Ormond Street Hospital for Children NHS Trust, and Institute of Child Health, London, UK
Dev Med Child Neurol 44:273-7. 2002..All four children made an apparently full recovery within four months of the onset.We suggest that these patients represent an immune-mediated movement disorder and encephalopathy syndrome... - Unihemispheric cerebral vasculitis mimicking Rasmussen's encephalitisC Derry
Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
Neurology 58:327-8. 2002 - Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured proteinKevin C O'Connor
Center for Neurologic Diseases, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Med 13:211-7. 2007..MOG-specific autoantibodies were identified in a subset of ADEM but only rarely in adult-onset MS cases, indicating that MOG is a more prominent target antigen in ADEM than MS... - Early relapse risk after a first CNS inflammatory demyelination episode: examining international consensus definitionsRussell C Dale
Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, Australia
Dev Med Child Neurol 49:887-93. 2007..However, it is hoped that these new criteria may improve prognostic specificity and provide uniformity to future paediatric CNS demyelination research... - Incidence of anti-brain antibodies in children with obsessive-compulsive disorderRussell C Dale
Department of Child and Adolescent Psychiatry, PO Box 085, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 187:314-9. 2005..CONCLUSIONS: Our findings support the hypothesis that central nervous system autoimmunity may have a role in a significant subgroup of cases of OCD. Further study is required to examine whether the antibodies concerned are pathogenic... - Antibasal ganglia antibodies and PANDASDavide Martino
Mov Disord 20:116-7. 2005 - Dementia-like presentation of striatal hypermetabolic state with antistriatal antibodies responsive to steroidsGabriel C Léger
Neurology Service, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Arch Neurol 61:754-7. 2004..Hypermetabolic lesions of the striatum are rare. They usually involve autoimmunity and are associated with choreatic disorders such as Sydenham chorea, lupus, and the antiphospholipid antibody syndrome... - Parkinsonian features after streptococcal pharyngitisHilla Ben-Pazi
Pediatric Department, Hadassah University Hospital, Ein Kerem, POB 12000, Jerusalem 91120, Israel
J Pediatr 143:267-9. 2003..We suggest that autoimmune antibodies may cause remitting parkinsonian signs subsequent to streptococcal tonsillitis as part of the spectrum of poststreptococcal CNS disease... - New autoantibody mediated disorders of the central nervous systemBethan Lang
Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Curr Opin Neurol 16:351-7. 2003..This review summarizes the recent findings and assesses the evidence that these conditions are caused by the antibodies, using the criteria established for peripheral nervous system autoimmune diseases... - Post-streptococcal autoimmune psychiatric and movement disorders in childrenRussell C Dale
Br J Psychiatry 181:188-90. 2002 - Antistreptolysin-O titers: implications for adult PANDAS. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infectionsAndrew J Church
Am J Psychiatry 159:320. 2002 - Normal MRI neuroimaging and acute dancing eyes syndromeRussell C Dale
Dev Med Child Neurol 44:356. 2002 - Contemporary encephalitis lethargica presenting with agitated catatonia, stereotypy, and dystonia-parkinsonismRussell C Dale
Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Mov Disord 22:2281-4. 2007..We believe these cases support the hypothesis that this syndrome is an inflammatory encephalitis that specifically effects dopamine neurotransmission... - Acute disseminated encephalomyelitis: where does it start and where does it stop?Russell C Dale
Discipline of Paediatrics and Child Health Faculty of Medicine, University of Sydney, Australia
Dev Med Child Neurol 50:326-7. 2008