Research Topics
Species | Alan ConnellySummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Neural bases of childhood speech disorders: lateralization and plasticity for speech functions during developmentFrédérique J Liégeois
Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Neurosci Biobehav Rev 36:439-58. 2012..In conclusion, for the first time we provide evidence that longterm and severe childhood speech disorders result predominantly from bilateral disruption of the neural networks involved in speech production...- Speaking with a single cerebral hemisphere: fMRI language organization after hemispherectomy in childhoodFrédérique Liégeois
Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Brain Lang 106:195-203. 2008..The results suggest that distinct subregions of Broca's area and their right homologs can subserve speech and language, and that this variability may determine functional outcome... - Role of fMRI in the decision-making process: epilepsy surgery for childrenFrédérique Liégeois
Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, United Kingdom
J Magn Reson Imaging 23:933-40. 2006..In our experience, fMRI has significantly contributed to the decision-making process, and improved the counseling and management of young people with intractable epilepsy... - Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI studyF Liegeois
Developmental Cognitive Neuroscience Unit, Institute of Child Health, UCL, 4th Floor, 30 Guilford Street, London WC1N 1EH, UK
Brain 127:1229-36. 2004..In conclusion, it is difficult to infer intra- versus inter-hemispheric language reorganization on the basis of clinical observations in the presence of early pathology to the left hemisphere... - Language after hemispherectomy in childhood: contributions from memory and intelligenceFrédérique Liégeois
Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH UK
Neuropsychologia 46:3101-7. 2008.... - Language fMRI abnormalities associated with FOXP2 gene mutationFrédérique Liégeois
Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK
Nat Neurosci 6:1230-7. 2003..Our findings suggest that the FOXP2 gene is critically involved in the development of the neural systems that mediate speech and language... - Speech and oral motor profile after childhood hemispherectomyFrédérique Liégeois
UCL Institute of Child Health, London, UK
Brain Lang 114:126-34. 2010..These results indicate incomplete functional re-organization for the control of fine speech motor movements throughout childhood, and provide no evidence of hemispheric differences... - Endophenotypes of FOXP2: dysfunction within the human articulatory networkF Liegeois
Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Eur J Paediatr Neurol 15:283-8. 2011..We suggest that nonword repetition is the optimal endophenotype for FOXP2 disruption in humans because this task recruits brain regions involved in the imitation and vocal learning of novel sequences of speech sounds... - Influence of motor functional magnetic resonance imaging on the surgical management of children and adolescents with symptomatic focal epilepsyXavier De Tiège
Neurosciences Unit, University College London Institute of Child Health, London, United Kingdom
Neurosurgery 64:856-64; discussion 864. 2009..To determine the clinical value of motor functional magnetic resonance imaging (fMRI) in the presurgical evaluation of a large group of children and adolescents with epilepsy caused by lesions close to the central sulcus... - Extra-hippocampal grey matter density abnormalities in paediatric mesial temporal sclerosisFrancesca Cormack
Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
Neuroimage 27:635-43. 2005.... - Prolonged febrile seizures are associated with hippocampal vasogenic edema and developmental changesRod C Scott
Neurosciences Unit, Institute of Child Health, University College London, London, UK
Epilepsia 47:1493-8. 2006.... - Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolutionJ Donald Tournier
Radiology and Physics Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, London, WC1N 1EH, UK
Neuroimage 23:1176-85. 2004..5-T clinical scanner. The technique can recover the fiber ODF in regions of multiple fiber crossing and holds promise for applications such as tractography... - Cortical abnormalities and language function in young patients with basal ganglia strokeAlison Rowan
Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London WClN 1EH, UK
Neuroimage 36:431-40. 2007..We suggest that language impairments following basal ganglia damage may be attributable primarily to abnormalities in cortical language areas that are too subtle to detect on conventional structural MRI... - Reduction of errors in ASL cerebral perfusion and arterial transit time maps using image de-noisingJack A Wells
Wellcome Trust Advanced MR Imaging Group, Department of Medical Physics and Bioengineering, University College London, London, UK
Magn Reson Med 64:715-24. 2010..A number of these methods (and particularly independent component analysis) were shown to achieve this aim without compromising image contrast... - Bolus delay and dispersion in perfusion MRI: implications for tissue predictor models in strokeFernando Calamante
Radiology and Physics Unit, UCL Institute of Child Health, University College London, London, UK
Magn Reson Med 55:1180-5. 2006..The results are compared with previous numerical simulations, and their implications for the assessment and management of acute stroke are discussed... - EEG-fMRI in children with pharmacoresistant focal epilepsyXavier De Tiège
Neuroscience Unit, UCL Institute of Child Health, London, United Kingdom
Epilepsia 48:385-9. 2007..To evaluate the usefulness of EEG-combined functional magnetic resonance imaging (EEG-fMRI) to localize epileptogenic sources... - Cortical lateralization during verb generation: a combined ERP and fMRI studyAlison Rowan
Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London, WC1N 1EH, UK
Neuroimage 22:665-75. 2004..Thus, ERPs and fMRI provided convergent evidence regarding language lateralization, with ERPs revealing the temporal sequence of posterior to anterior cortical activation during semantic retrieval... - Hippocampal abnormalities after prolonged febrile convulsion: a longitudinal MRI studyRod C Scott
Neurosciences Unit, Institute of Child Health, University College London, UK
Brain 126:2551-7. 2003..Alternatively, the asymmetry could represent return (post-acute oedema) to a pre-existing hippocampal abnormality similar to that identified in family members of patients with MTS and a history of PFC... - Improved deconvolution of perfusion MRI data in the presence of bolus delay and dispersionLisa Willats
Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
Magn Reson Med 56:146-56. 2006..Such maps would be a useful adjunct for interpreting bolus-tracking data... - Is quantification of bolus tracking MRI reliable without deconvolution?Joanna E Perthen
Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
Magn Reson Med 47:61-7. 2002..The results presented here show that the use of summary parameters requires considerable caution, since tissue or patient types can easily be incorrectly classified due to the effect of variations in patient AIF and R(t)... - Diffusion-weighted magnetic resonance imaging fibre tracking using a front evolution algorithmJ Donald Tournier
Radiology and Physics Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Neuroimage 20:276-88. 2003..Example tracks are shown to illustrate some of the properties of the algorithm, such as robustness to noise and branching capability. Finally, the dependence of the algorithm on the model used to derive the fibre ODF is discussed... - Modified constraint-induced movement therapy after childhood strokeAnne Gordon
Neurosciences Unit, Institute of Child Health, University College London, London, UK
Dev Med Child Neurol 49:23-7. 2007..The use of mCIT is a promising intervention for children with chronic acquired hemiparesis. In this severely impaired group functional improvements were seen after therapy despite unchanged sensorimotor measures... - Sickle cell disease: ischemia and seizuresMara Prengler
Neurosciences Unit, Institute of Child Health, University College London, London, United Kingdom
Ann Neurol 58:290-302. 2005..These findings suggest that vasculopathy and focal hypoperfusion may be factors in the development of sickle cell disease-associated seizures... - Ophthalmological, cognitive, electrophysiological and MRI assessment of visual processing in preterm children without major neuromotor impairmentMichelle O'Reilly
Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, UK
Dev Sci 13:692-705. 2010..Whilst this P100 finding suggests that subtle abnormalities may exist at the neurophysiological level, we conclude that visual dysfunction is not systematically associated with preterm birth in the context of normal neurological status... - Abnormalities in hippocampi remote from the seizure focus: a T2 relaxometry studyRod C Scott
Neurosciences Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, UK
Brain 126:1968-74. 2003.... - Quantification of bolus-tracking MRI: Improved characterization of the tissue residue function using Tikhonov regularizationFernando Calamante
Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
Magn Reson Med 50:1237-47. 2003..On the other hand, the use of the proposed regularization method improves the characterization of the tissue residue function... - Sickle cell disease and electroencephalogram hyperventilationMara Prengler
Ann Neurol 59:214-5. 2006 - Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolutionJ Donald Tournier
Brain Research Institute, Melbourne, Australia
Neuroimage 35:1459-72. 2007..This should allow tractography algorithms to be designed that are able to track reliably through crossing fibre regions...