Peter N Cockerill

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi NFAT is well placed to direct both enhancer looping and domain-wide models of enhancer function
    Peter N Cockerill
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, UK
    Sci Signal 1:pe15. 2008
  2. ncbi Structure and function of active chromatin and DNase I hypersensitive sites
    Peter N Cockerill
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, UK
    FEBS J 278:2182-210. 2011
  3. ncbi Transcription-dependent silencing of inducible convergent transgenes in transgenic mice
    Fernando J Calero Nieto
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Epigenetics Chromatin 3:3. 2010
  4. ncbi A conserved insulator that recruits CTCF and cohesin exists between the closely related but divergently regulated interleukin-3 and granulocyte-macrophage colony-stimulating factor genes
    Sarion R Bowers
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    Mol Cell Biol 29:1682-93. 2009
  5. ncbi The human IL-3/granulocyte-macrophage colony-stimulating factor locus is epigenetically silent in immature thymocytes and is progressively activated during T cell development
    Fabio Mirabella
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, United Kingdom
    J Immunol 184:3043-54. 2010
  6. ncbi Mechanisms of transcriptional regulation of the human IL-3/GM-CSF locus by inducible tissue-specific promoters and enhancers
    Peter N Cockerill
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    Crit Rev Immunol 24:385-408. 2004
  7. ncbi Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer
    Sarion R Bowers
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Nucleic Acids Res 38:6124-34. 2010
  8. ncbi A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling
    Andrew G Bert
    Experimental Haematology, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    Mol Cell Biol 27:2870-85. 2007
  9. ncbi The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription
    Pascal Lefevre
    Leeds Institute of Molecular Medicine, University of Leeds, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, UK
    Mol Cell 32:129-39. 2008
  10. ncbi Chromatin mechanisms regulating gene expression in health and disease
    Constanze Bonifer
    Section of Experimental Haematology Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, UK
    Adv Exp Med Biol 711:12-25. 2011

Collaborators

  • Fernando J Calero-Nieto
  • C Bonifer
  • Daniel G Tenen
  • Pascal Lefevre
  • Matthias Merkenschlager
  • James B Rance
  • Luigina Mollica
  • Ke Liu
  • Sarion R Bowers
  • Andrew G Bert
  • Fabio Mirabella
  • Euan W Baxter
  • Hiromi Tagoh
  • Brett V Johnson
  • Fernando J Calero Nieto
  • Stephanie Valeaux
  • Maarten Hoogenkamp
  • Monica Arman
  • Abbas Hawwari
  • Narcis Fernandez-Fuentes
  • Sally R James
  • Marjorie Boissinot
  • Suzana Hadjur
  • Hanna Krysinska
  • Rachael Barlow
  • Gang Huang
  • Alexander Ebralidze
  • Richard Ingram
  • Pu Zhang
  • Deborah Clarke
  • Javier Calvo
  • Manuel López-Cabrera
  • Maria E Trojanowska
  • Francisco Lozano
  • Mônica Santana
  • Jordi Vives
  • Antony Condina
  • Gregory R Ryan
  • Mathew A Vadas
  • Joanna Burrows

Detail Information

Publications17

  1. ncbi NFAT is well placed to direct both enhancer looping and domain-wide models of enhancer function
    Peter N Cockerill
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, UK
    Sci Signal 1:pe15. 2008
    ..Taken together, these studies highlight NFAT as a factor that creates a chromatin environment that is permissive for both the recruitment and the clustering of factors that control transcription at promoters and enhancers...
  2. ncbi Structure and function of active chromatin and DNase I hypersensitive sites
    Peter N Cockerill
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, UK
    FEBS J 278:2182-210. 2011
    ..In this review I will discuss the chromatin structural changes that occur at active gene loci and at regulatory elements that exist as DNase I hypersensitive sites...
  3. ncbi Transcription-dependent silencing of inducible convergent transgenes in transgenic mice
    Fernando J Calero Nieto
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Epigenetics Chromatin 3:3. 2010
    ..This mechanism may account for a significant proportion of the reported cases of transgene inactivation in mice...
  4. ncbi A conserved insulator that recruits CTCF and cohesin exists between the closely related but divergently regulated interleukin-3 and granulocyte-macrophage colony-stimulating factor genes
    Sarion R Bowers
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    Mol Cell Biol 29:1682-93. 2009
    ..We suggest that one important role of these sites is to enable the independent regulation of the IL-3 and GM-CSF genes...
  5. ncbi The human IL-3/granulocyte-macrophage colony-stimulating factor locus is epigenetically silent in immature thymocytes and is progressively activated during T cell development
    Fabio Mirabella
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, United Kingdom
    J Immunol 184:3043-54. 2010
    ..Significantly, we also found that memory CD4 positive T cells, but not naive T cells, maintain a remodeled chromatin structure resembling that seen in T blast cells...
  6. ncbi Mechanisms of transcriptional regulation of the human IL-3/GM-CSF locus by inducible tissue-specific promoters and enhancers
    Peter N Cockerill
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    Crit Rev Immunol 24:385-408. 2004
    ....
  7. ncbi Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer
    Sarion R Bowers
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Nucleic Acids Res 38:6124-34. 2010
    ....
  8. ncbi A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling
    Andrew G Bert
    Experimental Haematology, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    Mol Cell Biol 27:2870-85. 2007
    ..These studies reveal that distinct tissue-specific mechanisms can be used either alternately or in combination to activate the same enhancer...
  9. ncbi The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription
    Pascal Lefevre
    Leeds Institute of Molecular Medicine, University of Leeds, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, UK
    Mol Cell 32:129-39. 2008
    ..Each of these events requires transcription elongation. Our data reveal a transcription-dependent mechanism of chromatin remodeling that switches a cis-regulatory region from a repressive to an active conformation...
  10. ncbi Chromatin mechanisms regulating gene expression in health and disease
    Constanze Bonifer
    Section of Experimental Haematology Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, UK
    Adv Exp Med Biol 711:12-25. 2011
    ....
  11. ncbi The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis
    Maarten Hoogenkamp
    University of Leeds, Leeds Institute of Molecular Medicine, St James s University Hospital, University of Leeds, Leeds LS9 7TF, United Kingdom
    Mol Cell Biol 27:7425-38. 2007
    ..Our results provide important insights into how overlapping, but different, sets of transcription factors program tissue-specific chromatin structures in the hematopoietic system...
  12. ncbi Granulocyte-macrophage colony-stimulating factor enhancer activation requires cooperation between NFAT and AP-1 elements and is associated with extensive nucleosome reorganization
    Brett V Johnson
    Molecular Medicine Unit, Department of Medicine, St James s University Hospital, University of Leeds, Leeds, England
    Mol Cell Biol 24:7914-30. 2004
    ..Hence, NFAT has the potential to cooperate with other transcription factors by promoting chromatin remodelling and increasing accessibility at inducible regulatory elements...
  13. ncbi In vivo genomic footprinting using LM-PCR methods
    Hiromi Tagoh
    Molecular Medicine Unit, St. James's University Hospital, University of Leeds, United Kingdom
    Methods Mol Biol 325:285-314. 2006
    ..In this chapter, we describe detailed procedures for the examination of chromatin fine-structure and nucleosome positioning as well as changes in transcription factor binding-site occupancy during cellular differentiation...
  14. ncbi Transcriptional regulation of human CD5: important role of Ets transcription factors in CD5 expression in T cells
    Monica Arman
    Servei d Immunologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic i Provincial de Barcelona, Villaroel 170, Barcelona 08036, Spain
    J Immunol 172:7519-29. 2004
    ....
  15. ncbi Regulation of the human endothelial cell protein C receptor gene promoter by multiple Sp1 binding sites
    James B Rance
    Department of Haematology, Imperial College London Faculty of Medicine, Hammersmith Hospital Campus, London, United Kingdom
    Blood 101:4393-401. 2003
    ..We conclude that transcription factor binding to Sp1 binding sites in the 5' flanking region is critical for normal hEPCR gene expression in endothelial cells...
  16. ncbi The human IL-3 locus is regulated cooperatively by two NFAT-dependent enhancers that have distinct tissue-specific activities
    Abbas Hawwari
    Hanson Center for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    J Immunol 169:1876-86. 2002
    ..This element lacked in vitro enhancer function, but may have a developmental role because it appears to be the first DH site to exist upstream of the IL-3 gene during hemopoietic development before IL-3 expression...
  17. ncbi Role of a 5'-enhancer in the transcriptional regulation of the human endothelial cell protein C receptor gene
    Luigina R Mollica
    Department of Haematology, Imperial College London, UK
    Blood 108:1251-9. 2006
    ....