David Coates

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase function
    D Coates
    School of Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem Soc Trans 28:464-9. 2000
  2. ncbi The angiotensin converting enzyme (ACE)
    David Coates
    Faculty of Biological Sciences, School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Int J Biochem Cell Biol 35:769-73. 2003
  3. ncbi Mining proteases in the genome databases
    David Coates
    School of Biology, University of Leeds, Leeds LS2 9JT, U K
    Essays Biochem 38:185-96. 2002
  4. ncbi A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide
    R Isaac
    Department of Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem J 330:61-5. 1998
  5. ncbi Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme
    D Coates
    School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Biochemistry 39:8963-9. 2000
  6. ncbi Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin
    R E Isaac
    School of Biology, University of Leeds, UK
    Eur J Biochem 262:569-74. 1999
  7. ncbi Insect angiotensin-converting enzyme. A processing enzyme with broad substrate specificity and a role in reproduction
    R E Isaac
    School of Biology, University of Leeds, United Kingdom
    Ann N Y Acad Sci 897:342-7. 1999
  8. ncbi Conserved roles for peptidases in the processing of invertebrate neuropeptides
    R E Isaac
    School of Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem Soc Trans 28:460-4. 2000
  9. ncbi The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function
    A J Turner
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK
    Bioessays 23:261-9. 2001
  10. ncbi Functional redundancy of two nucleoside transporters of the ENT family (CeENT1, CeENT2) required for development of Caenorhabditis elegans
    Peter J Appleford
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Mol Membr Biol 21:247-59. 2004

Collaborators

Detail Information

Publications14

  1. ncbi Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase function
    D Coates
    School of Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem Soc Trans 28:464-9. 2000
    ....
  2. ncbi The angiotensin converting enzyme (ACE)
    David Coates
    Faculty of Biological Sciences, School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Int J Biochem Cell Biol 35:769-73. 2003
    ..The importance of therapies involving inhibition of angiotensin converting enzyme are undisputed, but our understanding of how and why these therapies work is now being informed by the tools of genomic and comparative biology...
  3. ncbi Mining proteases in the genome databases
    David Coates
    School of Biology, University of Leeds, Leeds LS2 9JT, U K
    Essays Biochem 38:185-96. 2002
    ....
  4. ncbi A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide
    R Isaac
    Department of Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem J 330:61-5. 1998
    ....
  5. ncbi Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme
    D Coates
    School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Biochemistry 39:8963-9. 2000
    ..The conservation of ACE enzymes with distinct active sites in the evolution of both vertebrate and invertebrate species provides further evidence that these two kinds of active sites have different physiological functions...
  6. ncbi Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin
    R E Isaac
    School of Biology, University of Leeds, UK
    Eur J Biochem 262:569-74. 1999
    ..6 in favour of the N-domain). We conclude that somatic forms of ACE should be considered as alternatives to CPs for the removal of basic residues from some Arg/Lys-extended peptides...
  7. ncbi Insect angiotensin-converting enzyme. A processing enzyme with broad substrate specificity and a role in reproduction
    R E Isaac
    School of Biology, University of Leeds, United Kingdom
    Ann N Y Acad Sci 897:342-7. 1999
    ..In this paper we review some of the recent findings about insect ACE, and we speculate as to the physiological role of this enzyme in insect reproduction...
  8. ncbi Conserved roles for peptidases in the processing of invertebrate neuropeptides
    R E Isaac
    School of Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem Soc Trans 28:460-4. 2000
    ..Invertebrates will continue to provide insights into the evolutionarily conserved functions of known peptidases and of those additional family members that are expected to be identified in the future from genome-sequencing projects...
  9. ncbi The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function
    A J Turner
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK
    Bioessays 23:261-9. 2001
    ..These model organisms also provide convenient systems for examining cell-specific expression, developmental and functional roles of this peptidase family, and reveal the power of functional genomics...
  10. ncbi Functional redundancy of two nucleoside transporters of the ENT family (CeENT1, CeENT2) required for development of Caenorhabditis elegans
    Peter J Appleford
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Mol Membr Biol 21:247-59. 2004
    ..Although disruption of ent-1 or ent-2 expression alone had no effect, simultaneous disruption of both genes yielded pronounced developmental defects involving the intestine and vulva...
  11. ncbi Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans
    V Laurent
    Molecular and Cellular Biosciences, Faculty of Biological Sciences, Miall Building, University of Leeds, UK
    Eur J Biochem 268:5430-8. 2001
    ....
  12. ncbi Characterisation of putative Drosophila angiotensin converting enzyme cDNA clones
    M J Cornell
    Department of Pure and Applied Biology, University of Leeds, UK
    Biochem Soc Trans 21:243S. 1993
  13. ncbi Expression and characterisation of a Psoroptes ovis glutathione S-transferase
    Alison J Lee
    School of Biology, The University of Leeds, LS2 9JT, Leeds, UK
    Vet Parasitol 105:49-63. 2002
    ..Neutrophil, mast cell and basophil counts were not significantly different to the controls. Eosinophil numbers were significantly higher than controls, but were not due to an IgE response...
  14. ncbi Expression and functional characterization of a Drosophila neuropeptide precursor with homology to mammalian preprotachykinin A
    R J Siviter
    School of Biology, University of Leeds, Leeds, West Yorkshire LS2 9JT, United Kingdom
    J Biol Chem 275:23273-80. 2000
    ..These data provide additional evidence for the conservation of both the structure and function of the tachykinin peptides in the brain and gut during the course of evolution...