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Genomes and GenesSpecies | Geoffrey CoastSummaryAffiliation: University of London Country: UK Publications
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Publications
Toward a consensus nomenclature for insect neuropeptides and peptide hormonesGeoffrey M Coast
School of Biological and Chemical Sciences, Birkbeck University of London, Malet Street, London WC1E 7HX, UK
Peptides 32:620-31. 2011..The proposed scheme is sufficiently flexible to allow the incorporation of novel peptides, and could be extended to other arthropods and non-arthropod invertebrates...- The endocrine control of salt balance in insectsGeoffrey Coast
School of Biological and Chemical Sciences, Birkbeck University of London, Malet Street, London WC1E 7HX, UK
Gen Comp Endocrinol 152:332-8. 2007..Particular emphasis is given to in vitro studies of the effect of neurohormones on Malpighian tubule ion transport and a consideration of their likely role in the regulation of salt balance in vivo... - Neuropeptide control of fluid balance in insectsGeoffrey M Coast
School of Biological and Chemical Sciences, Birkbeck, University of London, UK
Ann N Y Acad Sci 1040:1-8. 2005.... - An antidiuretic peptide (Tenmo-ADFb) with kinin-like diuretic activity on Malpighian tubules of the house cricket, Acheta domesticus (L.)Geoffrey M Coast
School of Biological and Chemical Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK
J Exp Biol 210:3979-89. 2007..Although the actions of Tenmo-ADFb are indistinguishable from those of Achdo-KII, it is unlikely to act at a kinin receptor, because the core sequence (residues 7-12) lacks the Phe and Trp residues that are critical for kinin activity... - Continuous recording of excretory water loss from Musca domestica using a flow-through humidity meter: hormonal control of diuresisGeoffrey M Coast
Department of Biology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
J Insect Physiol 50:455-68. 2004..Evidence is presented for Musdo-K having a hormonal role in the control of diuresis, although other neuropeptides may also be implicated... - Neuroendocrine control of ionic homeostasis in blood-sucking insectsGeoffrey M Coast
Birkbeck College, School of Biological and Chemical Sciences, London, WC1E 7HX UK
J Exp Biol 212:378-86. 2009..At such times, the hindgut has a negligible impact on the volume and composition of the final urine, and neurohormones acting on the Malpighian tubules have a dominant role in the control of ionic homeostasis... - Neurohormones implicated in the control of Malpighian tubule secretion in plant sucking heteropterans: The stink bugs Acrosternum hilare and Nezara viridulaGeoffrey M Coast
School of Biological and Chemical Sciences, Birkbeck University of London, Malet Street, London WC1E 7HX, UK
Peptides 31:468-73. 2010..prolixus. The antidiuretic activity of Rhopr-CAPA-2 has been linked with terminating the rapid diuresis, but results with stink bugs suggest it is a general feature of heteropteran MT... - Serotonin has kinin-like activity in stimulating secretion by Malpighian tubules of the house cricket Acheta domesticusGeoffrey Coast
Birkbeck, School of Biological and Chemical Sciences, Malet Street, London WC1E 7HX, United Kingdom
Peptides 32:500-8. 2011..The results are consistent with the diuretic activity of serotonin being mediated through a 5-HT(2)-like receptor... - The control of Malpighian tubule secretion in a predacious hemipteran insect, the spined soldier bug Podisus maculiventris (Heteroptera, Pentatomidae)Geoffrey M Coast
Birkbeck University of London, School of Biological and Chemical Sciences, Malet Street, London WC1E 7HX, United Kingdom
Peptides 32:493-9. 2011..On the other hand, the antidiuretic activity of members of the CAP(2b) family in all three bugs is consistent with this being a heteropteran feature rather than a specialism for hematophagy... - Diuretic and myotropic activities of N-terminal truncated analogs of Musca domestica kinin neuropeptideGeoffrey M Coast
School of Biological and Chemical Sciences, Birkbeck College, WC1E 7HX, London, UK
Peptides 23:701-8. 2002.... - The Drosophila melanogaster homologue of an insect calcitonin-like diuretic peptide stimulates V-ATPase activity in fruit fly Malpighian tubulesG M Coast
Department of Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK
J Exp Biol 204:1795-804. 2001..Since the K+ concentration of the secreted urine was unchanged, it is likely that Drome-DH31 has an equal effect on K+ and Na+ entry across the basolateral membrane... - Diuresis in the housefly (Musca domestica) and its control by neuropeptidesG M Coast
Department of Biology, Birkbeck College, London, United Kingdom
Peptides 22:153-60. 2001..Diuresis is partially blocked by injected anti-muscakinin antibodies, providing evidence of a hormonal function for this insect myokinin... - Mosquito natriuretic peptide identified as a calcitonin-like diuretic hormone in Anopheles gambiae (Giles)Geoffrey M Coast
Department of Biology, Birkbeck University of London, London WC1E 7HX, UK
J Exp Biol 208:3281-91. 2005..We conclude that the CT-like peptide Anoga-DH31 is the previously uncharacterised mosquito natriuretic peptide... - The influence of neuropeptides on Malpighian tubule writhing and its significance for excretionG M Coast
Department of Biology, Birkbeck College, London, UK
Peptides 19:469-80. 1998..Tubule writhing also serves to reduce unstirred layers (USLs) at the basolateral surface of the epithelium and thereby facilitates the excretion of solutes entering the lumen by passive diffusion... - Comparison of insect kinin analogs with cis-peptide bond motif 4-aminopyroglutamate identifies optimal stereochemistry for diuretic activityKrzysztof Kaczmarek
Areawide Pest Management Research Unit, Southern Plains Agricultural Research Center, ARS, U S Department of Agriculture, College Station, TX 77845, USA
Biopolymers 88:1-7. 2007..The work identifies the optimal stereochemistry for the APy scaffold with which to design biostable, peptidomimetic analogs with the potential to disrupt critical insect kinin-regulated processes in insects... - cis-peptide bond mimetic tetrazole analogs of the insect kinins identify the active conformationRonald J Nachman
Veterinary Entomology Research Laboratory, ARS, U S Department of Agriculture, 2881 F B Road, College Station, TX 77845, USA
Peptides 23:709-16. 2002.... - Enhanced in vivo activity of peptidase-resistant analogs of the insect kinin neuropeptide familyRonald J Nachman
Veterinary Entomology Research Laboratory, ARS, U S Department of Agriculture, 2881 F B Road, College Station, TX 77845, USA
Peptides 23:735-45. 2002..Potent peptidase resistant analogs of the insect kinins, coupled with an increased understanding of related regulatory factors, offer promise in the development of new, environmentally friendly pest insect control measures... - A C-terminal aldehyde insect kinin analog enhances inhibition of weight gain and induces significant mortality in Helicoverpa zea larvaeRonald J Nachman
Areawide Pest Management Research, Southern Plains Agricultural Research Center, USDA, 2881 F B Road, College Station, TX 77845, USA
Peptides 24:1615-21. 2003..Boc-VFFPWG-H represents a lead analog in the development of novel, environmentally friendly pest insect management agents based on the insect kinin class of neuropeptides... - An active insect kinin analog with 4-aminopyroglutamate, a novel cis-peptide bond, type VI beta-turn motifRonald J Nachman
Areawide Pest Management Research Unit, Southern Plains Agricultural Research Center, ARS, U S Department of Agriculture, 2881 F B Rd, College Station, TX 77845, USA
Biopolymers 75:412-9. 2004.... - Mass spectrometric assignment of Leu/Ile in neuropeptides from single neurohemal organ preparations of insectsRonald J Nachman
Areawide Pest Management Research, Southern Plains Agricultural Research Center, USDA, 2881 F B Road, College Station, TX 77845, USA
Peptides 26:2151-6. 2005..5 times more active than the native Leu sequence in a housefly Malpighian tubule fluid secretion assay, which reinforces the caveat that potency values in a biological assay cannot be relied upon to predict the native sequence... - Structure-activity relationships for in vitro diuretic activity of CAP2b in the houseflyRonald J Nachman
Areawide Pest Management Research, Southern Plains Agricultural Research Center, USDA, College Station, TX 77845, USA
Peptides 28:57-61. 2007.... - A C-terminal aldehyde analog of the insect kinins inhibits diuresis in the houseflyRonald J Nachman
Areawide Pest Management Research Unit, Southern Plains Agricultural Research Center, U S Department of Agriculture, College Station, TX 77845, USA
Peptides 28:146-52. 2007..The selective inhibitory activity of R-LK-CHO on housefly tubules represents an important lead in the development of environmentally friendly insect management agents based on the insect kinins... - Beta-amino acid analogs of an insect neuropeptide feature potent bioactivity and resistance to peptidase hydrolysisPawel Zubrzak
Areawide Pest Management Research Unit, Southern Plains Agricultural Research Center, U S Department of Agriculture, 2881 F B Road, College Station, TX, USA
Biopolymers 88:76-82. 2007..This paper describes the first instance of beta-amino acids analogs of an arthropod peptide that demonstrate significant bioactivity and resistance to peptidase degradation... - Identification of PVK/CAP2b neuropeptides from single neurohemal organs of the stable fly and horn fly via MALDI-TOF/TOF tandem mass spectrometryRonald J Nachman
Areawide Pest Management Research, Southern Plains Agricultural Research Center, USDA, 2881 F B Road, College Station, TX 77845, USA
Peptides 27:521-6. 2006..The identification of these novel neuropeptides adds to our knowledge of the peptidomes of flies, and can aid in the development of neuropeptide-based control strategies of these insect pests... - The effects of intracellular signalling pathway inhibitors on phagocytosis by haemocytes of Manduca sextaPatricia de Winter
School of Biological and Chemical Sciences, Birkbeck, University of London, London, UK
J Insect Physiol 53:975-82. 2007..JNK/SAPK did not seem to be involved in phagocytosis. The presence of protein phosphatases probably regulates phagocytosis at the intracellular level by dephosphorlyation of serine/threonine residues... - Occurrence of insect kinins in the flesh fly, stable fly and horn fly-mass spectrometric identification from single nerves and diuretic activityRonald J Nachman
Areawide Pest Management Research, Southern Plains Agricultural Research Center, USDA, 2881 F B Road, College Station, TX 77845, USA
Peptides 23:1885-94. 2002....