R B Clarke

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo
    Fredrik Warnberg
    Breast Biology Group, Christie Hospital NHS Trust, Manchester, UK
    Breast Cancer Res 8:R21. 2006
  2. ncbi High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?
    Andrew H Sims
    Breast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK
    Breast Cancer Res 8:214. 2006
  3. ncbi Isolation and characterization of human mammary stem cells
    R B Clarke
    Breast Biology Group, Division of Cancer Studies, University of Manchester, Christie Hospital, Wilmslow Road, Withington, Manchester, M20 4BX, UK
    Cell Prolif 38:375-86. 2005
  4. ncbi Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice: analysis of the relationship between estrogen-induced proliferation and progesterone receptor expression
    R B Clarke
    Clinical Research Department, Christie Hospital NHS Trust, Withington, Manchester, UK
    Breast Cancer Res Treat 45:121-33. 1997
  5. ncbi Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone
    R B Clarke
    Clinical Research Department, Christie Hospital NHS Trust, Withington, Manchester, UK
    Br J Cancer 75:251-7. 1997
  6. ncbi TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer
    A H Sims
    Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, UK
    Int J Radiat Biol 83:409-20. 2007
  7. ncbi Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status
    R B Clarke
    Clinical Research Dept, Christie Hospital NHS Trust, Withington, Manchester
    Br J Cancer 67:606-11. 1993
  8. ncbi Optimization of the reverse transcriptase polymerase chain reaction for the detection of circulating prostate cells
    I G McIntyre
    Department of Urology, Withington Hospital, Manchester, M21 1AH, UK
    Br J Cancer 83:992-7. 2000
  9. ncbi Breast stem cells and cancer
    G Farnie
    Breast Biology Group, School of Cancer and Imaging Sciences, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK
    Ernst Schering Found Symp Proc 5:141-53. 2006
  10. ncbi Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator
    N S Nguyen Huu
    University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    J Pathol 216:93-102. 2008

Collaborators

Detail Information

Publications16

  1. ncbi Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo
    Fredrik Warnberg
    Breast Biology Group, Christie Hospital NHS Trust, Manchester, UK
    Breast Cancer Res 8:R21. 2006
    ..Effects on tumour xenografts and human ductal carcinoma in situ (DCIS) of the breast in a xenograft mouse model were also tested...
  2. ncbi High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?
    Andrew H Sims
    Breast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK
    Breast Cancer Res 8:214. 2006
    ..Gene expression profiling is beginning to appear in the breast cancer clinic but it is not yet fully evaluated. This review explores the questions that must be addressed before this technology can become an everyday clinical tool...
  3. ncbi Isolation and characterization of human mammary stem cells
    R B Clarke
    Breast Biology Group, Division of Cancer Studies, University of Manchester, Christie Hospital, Wilmslow Road, Withington, Manchester, M20 4BX, UK
    Cell Prolif 38:375-86. 2005
    ..We speculate these two basic stem cell types may therefore be the cells of origin for ERalpha-positive and -negative breast tumours...
  4. ncbi Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice: analysis of the relationship between estrogen-induced proliferation and progesterone receptor expression
    R B Clarke
    Clinical Research Department, Christie Hospital NHS Trust, Withington, Manchester, UK
    Breast Cancer Res Treat 45:121-33. 1997
    ....
  5. ncbi Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone
    R B Clarke
    Clinical Research Department, Christie Hospital NHS Trust, Withington, Manchester, UK
    Br J Cancer 75:251-7. 1997
    ..The results are consistent with the suggestion that E2 may act to stimulate proliferation indirectly via a paracrine mechanism involving IGFs in normal as well as malignant human breast epithelial cells...
  6. ncbi TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer
    A H Sims
    Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, UK
    Int J Radiat Biol 83:409-20. 2007
    ..To evaluate a transcriptomic approach to identify healthy women at increased risk of breast cancer due to G2-radiosensitivity and look at transcripts that are differentially expressed between individuals...
  7. ncbi Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status
    R B Clarke
    Clinical Research Dept, Christie Hospital NHS Trust, Withington, Manchester
    Br J Cancer 67:606-11. 1993
    ..These data indicate that staining with the Ki67 antibody may be useful in monitoring response to anti-oestrogen therapy...
  8. ncbi Optimization of the reverse transcriptase polymerase chain reaction for the detection of circulating prostate cells
    I G McIntyre
    Department of Urology, Withington Hospital, Manchester, M21 1AH, UK
    Br J Cancer 83:992-7. 2000
    ..Each blood sample must be assayed several times with RT-PCR to avoid false-negative results and, if this is done, assay specificity can be increased with little effect on clinical sensitivity...
  9. ncbi Breast stem cells and cancer
    G Farnie
    Breast Biology Group, School of Cancer and Imaging Sciences, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK
    Ernst Schering Found Symp Proc 5:141-53. 2006
    ..Stem cell self-renewal pathways such as these may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer...
  10. ncbi Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator
    N S Nguyen Huu
    University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    J Pathol 216:93-102. 2008
    ..Thus, WWP1 is a prognostic marker and may be a potential therapeutic target for a subset of breast tumours...
  11. ncbi Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue
    C L Wilson
    Cancer Research UK Bioinformatics Group, Paterson Institute for Cancer Research, Wilmslow Road, Withington, Manchester M20 4BX, UK
    Endocr Relat Cancer 13:617-28. 2006
    ..This suggests that the response to oestrogen in normal breast is highly dependent upon epithelial-stromal/myoepithelial interactions which maintain the tissue microenvironment during epithelial cell proliferation...
  12. ncbi Human breast cell proliferation and its relationship to steroid receptor expression
    R B Clarke
    Breast Biology Group, Clinical Research Department, Christie Hospital, Manchester, UK
    Climacteric 7:129-37. 2004
    ....
  13. ncbi Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity
    G R Wilson
    Department of Academic Surgery, Research and Education Building 2nd Floor, South Manchester University Hospital, Wythenshawe, Manchester, UK
    Br J Cancer 95:1410-4. 2006
    ..011). Thus, high c-Src activity may identify a subset of DCIS with high risk of recurrence or progression to invasive cancer where therapeutics targeting c-Src may benefit this patient subset...
  14. ncbi Written report of presented lectures: endocrine treatment and prevention of breast and gynaecological cancers. The scientific basis of endocrine prevention
    A Howell
    CRC Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester, UK
    Eur J Cancer 38:S13-4. 2002
  15. ncbi Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis
    H A Coppock
    Centre for Molecular Medicine, University of Manchester, Manchester, UK
    Cell Prolif 40:721-40. 2007
    ..We aimed to determine whether p21(CIP1) or p27(KIP1) could induce a terminally differentiated phenotype in breast cells, and to examine if CDKI expression is regulated by basement membrane interactions...
  16. ncbi Effects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations
    M Bramley
    Department of Surgery, Christie Hospital NHS Trust, Manchester M20 4BX, USA
    Br J Cancer 94:1021-8. 2006
    ..We conclude that early anti-oestrogen treatment should prevent breast cancer in very high-risk women...