Sandra Cheesman

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Real-time quantitative PCR for analysis of genetically mixed infections of malaria parasites: technique validation and applications
    Sandra J Cheesman
    Division of Biological Sciences, Institute of Cell, Animal and Population Biology, Ashworth Laboratories, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 131:83-91. 2003
  2. ncbi Strain-specific immunity may drive adaptive polymorphism in the merozoite surface protein 1 of the rodent malaria parasite Plasmodium chabaudi
    Sandra Cheesman
    Institute for Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, The University of Edinburgh, The Kings Buildings, West Mains Road, Edinburgh EH93JT, UK
    Infect Genet Evol 9:248-55. 2009
  3. ncbi Validation of Pyrosequencing for accurate and high throughput estimation of allele frequencies in malaria parasites
    Sandra Cheesman
    Institute for Immunology and Infection Research, School of Biological Sciences, The University of Edinburgh, Ashworth Laboratories, The Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 152:213-9. 2007
  4. ncbi A single parasite gene determines strain-specific protective immunity against malaria: the role of the merozoite surface protein I
    Sandra Cheesman
    Institute of Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, The University of Edinburgh, The Kings Buildings, West Mains Road, Edinburgh EH93JT, UK
    Int J Parasitol 40:951-61. 2010
  5. ncbi Mixed strain infections and strain-specific protective immunity in the rodent malaria parasite Plasmodium chabaudi chabaudi in mice
    Sandra Cheesman
    School of Biological Sciences, Institute of Immunology and Infection Research, University of Edinburgh, The Kings Buildings, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Infect Immun 74:2996-3001. 2006
  6. ncbi Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites
    Paul Hunt
    Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratory, Kings Buildings, Edinburgh EH9 3JT, UK
    Mol Microbiol 65:27-40. 2007
  7. ncbi Linkage Group Selection--a fast approach to the genetic analysis of malaria parasites
    Richard Carter
    University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, West Mains Road, Edinburgh EH9 3JT, UK
    Int J Parasitol 37:285-93. 2007
  8. ncbi A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites
    Axel Martinelli
    Institute of Immunology and Infection Research, Ashworth Laboratories, King's Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 102:814-9. 2005
  9. ncbi Virulence and competitive ability in genetically diverse malaria infections
    Jacobus C de Roode
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Proc Natl Acad Sci U S A 102:7624-8. 2005
  10. ncbi Amplified fragment length polymorphism measures proportions of malaria parasites carrying specific alleles in complex genetic mixtures
    Axel Martinelli
    University of Edinburgh, Division of Biological Sciences, ICAPB, Ashworth Laboratory, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 136:117-22. 2004

Detail Information

Publications12

  1. ncbi Real-time quantitative PCR for analysis of genetically mixed infections of malaria parasites: technique validation and applications
    Sandra J Cheesman
    Division of Biological Sciences, Institute of Cell, Animal and Population Biology, Ashworth Laboratories, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 131:83-91. 2003
    ....
  2. ncbi Strain-specific immunity may drive adaptive polymorphism in the merozoite surface protein 1 of the rodent malaria parasite Plasmodium chabaudi
    Sandra Cheesman
    Institute for Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, The University of Edinburgh, The Kings Buildings, West Mains Road, Edinburgh EH93JT, UK
    Infect Genet Evol 9:248-55. 2009
    ..In contrast, two strains that do not induce reciprocal SSPI are identical at the 21 kDa region. Final identification of the region(s) controlling SSPI will provide important information to help guide decisions about MSP-1 based vaccines...
  3. ncbi Validation of Pyrosequencing for accurate and high throughput estimation of allele frequencies in malaria parasites
    Sandra Cheesman
    Institute for Immunology and Infection Research, School of Biological Sciences, The University of Edinburgh, Ashworth Laboratories, The Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 152:213-9. 2007
  4. ncbi A single parasite gene determines strain-specific protective immunity against malaria: the role of the merozoite surface protein I
    Sandra Cheesman
    Institute of Immunology and Infection Research, School of Biological Sciences, Ashworth Laboratories, The University of Edinburgh, The Kings Buildings, West Mains Road, Edinburgh EH93JT, UK
    Int J Parasitol 40:951-61. 2010
    ....
  5. ncbi Mixed strain infections and strain-specific protective immunity in the rodent malaria parasite Plasmodium chabaudi chabaudi in mice
    Sandra Cheesman
    School of Biological Sciences, Institute of Immunology and Infection Research, University of Edinburgh, The Kings Buildings, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Infect Immun 74:2996-3001. 2006
    ....
  6. ncbi Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites
    Paul Hunt
    Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratory, Kings Buildings, Edinburgh EH9 3JT, UK
    Mol Microbiol 65:27-40. 2007
    ..No mutations in the UBP-1 gene encoding the P. falciparum orthologue of the deubiquitinating enzyme were observed. The possible significance of these mutations in parasite responses to chloroquine or artemisinin is discussed...
  7. ncbi Linkage Group Selection--a fast approach to the genetic analysis of malaria parasites
    Richard Carter
    University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, West Mains Road, Edinburgh EH9 3JT, UK
    Int J Parasitol 37:285-93. 2007
    ..We have called the method Linkage Group Selection...
  8. ncbi A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites
    Axel Martinelli
    Institute of Immunology and Infection Research, Ashworth Laboratories, King's Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 102:814-9. 2005
    ..Another affected locus, unlinked to this selection valley, contained a member of the serine repeat antigen gene family...
  9. ncbi Virulence and competitive ability in genetically diverse malaria infections
    Jacobus C de Roode
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Proc Natl Acad Sci U S A 102:7624-8. 2005
    ..Our results imply that within-host competition is a major factor driving the evolution of virulence and can explain why many parasites harm their hosts...
  10. ncbi Amplified fragment length polymorphism measures proportions of malaria parasites carrying specific alleles in complex genetic mixtures
    Axel Martinelli
    University of Edinburgh, Division of Biological Sciences, ICAPB, Ashworth Laboratory, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 136:117-22. 2004
    ..The precision of the method is sufficient to detect reliably the effects of phenotypic selection at loci closely linked to a genetic locus under selection...
  11. ncbi Congenicity and genetic polymorphism in cloned lines derived from a single isolate of a rodent malaria parasite
    Sittiporn Pattaradilokrat
    Institute of Immunology and Infection Research, School of Biological Sciences, The University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Mol Biochem Parasitol 157:244-7. 2008
    ..The other genotype, genotype-2, is represented only by parasites with a slow growth phenotype (e.g. 17XA)...
  12. ncbi Host heterogeneity is a determinant of competitive exclusion or coexistence in genetically diverse malaria infections
    Jacobus C de Roode
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 271:1073-80. 2004
    ..Host genotype and resistance could therefore play a key role in the outcome of within-host competition between parasite clones and in the evolution of parasite virulence...