A Burkle

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi Mechanisms of ageing
    A Burkle
    Department of Gerontology, University of Newcastle upon Tyne, Newcastle General Hospital, UK
    Eye (Lond) 15:371-5. 2001
  2. ncbi Poly(ADP-ribosyl)ation, genomic instability, and longevity
    A Burkle
    Deutsches Krebsforschungszentrum, Abteilung Tumorvirologie, Heidelberg, Germany
    Ann N Y Acad Sci 908:126-32. 2000
  3. ncbi Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability
    A Burkle
    Department of Gerontology, Institute for the Health of the Elderly, University of Newcastle upon Tyne, IHE, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, NE4 6BE, UK
    Cancer Lett 163:1-5. 2001
  4. ncbi In memoriam Bernard Strehler--genomic instability in ageing: a persistent challenge
    Alexander Burkle
    Department of Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, NGH, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 123:899-906. 2002
  5. ncbi Physiology and pathophysiology of poly(ADP-ribosyl)ation
    A Burkle
    Department of Gerontology, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Bioessays 23:795-806. 2001
  6. ncbi Poly(ADP-ribosyl)ation: a posttranslational protein modification linked with genome protection and mammalian longevity
    A Burkle
    Deutsches Krebsforschungszentrum, Abteilung Tumorvirologie, Heidelberg, Germany
    Biogerontology 1:41-6. 2000
  7. ncbi Selective loss of poly(ADP-ribose) and the 85-kDa fragment of poly(ADP-ribose) polymerase in nucleoli during alkylation-induced apoptosis of HeLa cells
    R Alvarez-Gonzalez
    Division of Tumor Virology, German Cancer Research Center, Heidelberg, Germany
    J Biol Chem 274:32122-6. 1999
  8. ncbi Stress, DNA damage and ageing -- an integrative approach
    T von Zglinicki
    Department of Gerontology, Institute for the Health of the Elderly, Wolfson Research Centre, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Exp Gerontol 36:1049-62. 2001
  9. ncbi Inhibition of carcinogen-inducible DNA amplification in a simian virus 40-transformed hamster cell line by ethacridine or ethanol
    A Burkle
    Institut für Virusforschung, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    Cancer Res 49:2584-7. 1989
  10. ncbi Genomic structure, conservation and FISH mapping of the Rattus norvegicus Adprt gene
    S Beneke
    Abteilung Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    Cytogenet Genome Res 98:298-301. 2002

Collaborators

Detail Information

Publications10

  1. ncbi Mechanisms of ageing
    A Burkle
    Department of Gerontology, University of Newcastle upon Tyne, Newcastle General Hospital, UK
    Eye (Lond) 15:371-5. 2001
    ..Whether augmentation of cellular DNA repair capacity will have the same effect remains to be seen...
  2. ncbi Poly(ADP-ribosyl)ation, genomic instability, and longevity
    A Burkle
    Deutsches Krebsforschungszentrum, Abteilung Tumorvirologie, Heidelberg, Germany
    Ann N Y Acad Sci 908:126-32. 2000
    ....
  3. ncbi Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability
    A Burkle
    Department of Gerontology, Institute for the Health of the Elderly, University of Newcastle upon Tyne, IHE, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, NE4 6BE, UK
    Cancer Lett 163:1-5. 2001
    ....
  4. ncbi In memoriam Bernard Strehler--genomic instability in ageing: a persistent challenge
    Alexander Burkle
    Department of Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, NGH, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 123:899-906. 2002
    ....
  5. ncbi Physiology and pathophysiology of poly(ADP-ribosyl)ation
    A Burkle
    Department of Gerontology, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Bioessays 23:795-806. 2001
    ..Therefore pharmacological modulation of poly(ADP-ribosyl)ation may prove to be an exciting option for various highly prevalent, disabling and even lethal diseases...
  6. ncbi Poly(ADP-ribosyl)ation: a posttranslational protein modification linked with genome protection and mammalian longevity
    A Burkle
    Deutsches Krebsforschungszentrum, Abteilung Tumorvirologie, Heidelberg, Germany
    Biogerontology 1:41-6. 2000
    ....
  7. ncbi Selective loss of poly(ADP-ribose) and the 85-kDa fragment of poly(ADP-ribose) polymerase in nucleoli during alkylation-induced apoptosis of HeLa cells
    R Alvarez-Gonzalez
    Division of Tumor Virology, German Cancer Research Center, Heidelberg, Germany
    J Biol Chem 274:32122-6. 1999
    ....
  8. ncbi Stress, DNA damage and ageing -- an integrative approach
    T von Zglinicki
    Department of Gerontology, Institute for the Health of the Elderly, Wolfson Research Centre, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Exp Gerontol 36:1049-62. 2001
    ..We describe how an integrative approach to studying these mechanisms, coupled with computational modelling, may be of considerable importance in resolving some of the complexity of cellular ageing...
  9. ncbi Inhibition of carcinogen-inducible DNA amplification in a simian virus 40-transformed hamster cell line by ethacridine or ethanol
    A Burkle
    Institut für Virusforschung, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    Cancer Res 49:2584-7. 1989
    ..It is concluded that ethacridine or ethanol treatment uncouples the toxic effects of an alkylating agent or ionizing radiation from their ability to induce amplification in CO60 cells...
  10. ncbi Genomic structure, conservation and FISH mapping of the Rattus norvegicus Adprt gene
    S Beneke
    Abteilung Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    Cytogenet Genome Res 98:298-301. 2002
    ..Kimura protein distance comparison with human PARP-1 as reference revealed the bovine protein to be the least conserved with 10.3 substitutions per 100 amino acids, followed by rat (8.6) and mouse (8.4)...