Research Topics
Genomes and GenesSpecies | Amy H BuckSummaryAffiliation: University of Edinburgh Country: UK Publications
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Publications
Discrete clusters of virus-encoded micrornas are associated with complementary strands of the genome and the 7.2-kilobase stable intron in murine cytomegalovirusAmy H Buck
Division of Pathway Medicine, University of Edinburgh, Edinburgh, United Kingdom
J Virol 81:13761-70. 2007..One cluster of miRNAs occurs in close proximity to the 5' splice site of the previously identified 7.2-kb stable intron, implying a variety of potential regulatory mechanisms for MCMV miRNAs...
Post-transcriptional regulation of miR-27 in murine cytomegalovirus infectionAmy H Buck
Centre for Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh EH93JT, UK
RNA 16:307-15. 2010....
Improved silicon nitride surfaces for next-generation microarraysJonathan G Terry
Institute for Integrated Micro and Nano Systems, University of Edinburgh, Scottish Microelectronics Centre, West Mains Road, Edinburgh EH9 3JF, UK
Langmuir 22:11400-4. 2006....
A DNA nanoswitch incorporating the fluorescent base analogue 2-aminopurine detects single nucleotide mismatches in unlabelled targetsColin J Campbell
Division of Pathway Medicine, University of Edinburgh, Edinburgh, UK EH16 4SB
Analyst 134:1873-9. 2009....
Combined agonist-antagonist genome-wide functional screening identifies broadly active antiviral microRNAsDiwakar Santhakumar
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Proc Natl Acad Sci U S A 107:13830-5. 2010..Overall, we report a general strategy for examining the contributions of individual host miRNAs in viral infection and provide evidence that these molecules confer broad inhibitory potential against multiple viruses...
The evolution of RNAi as a defence against viruses and transposable elementsDarren J Obbard
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh EH9 3JT, UK
Philos Trans R Soc Lond B Biol Sci 364:99-115. 2009..Over longer time scales, key RNAi genes are repeatedly duplicated or lost across the metazoan phylogeny, with important implications for RNAi as an immune defence...
Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a targetValentina Libri
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Proc Natl Acad Sci U S A 109:279-84. 2012..This virus-host interaction reveals a mode of miRNA regulation in which a mRNA directs the degradation of a miRNA. We speculate that RNA-mediated miRNA degradation could be a more general viral strategy for manipulating host cells...
