Research Topics
Genomes and GenesSpecies | N H BrownSummaryAffiliation: University of Cambridge Country: UK Publications
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Detail Information
Publications
Talin is essential for integrin function in DrosophilaNicholas H Brown
Wellcome Trust Cancer Research UK Institute, University of Cambridge, United Kingdom
Dev Cell 3:569-79. 2002..These results indicate that talin is essential for integrin function and acts by stably linking clusters of ECM-linked integrins to the cytoskeleton...- An integrin chicken and egg problem: which comes first, the extracellular matrix or the cytoskeleton?N H Brown
Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Tennis Court Rd, CB2 1QR, Cambridge, UK
Curr Opin Cell Biol 12:629-33. 2000..Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word... - Cell-cell adhesion via the ECM: integrin genetics in fly and wormN H Brown
Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Tennis Court Rd, CB2 1QR, Cambridge, UK
Matrix Biol 19:191-201. 2000..The continued use of genetic approaches to identify proteins required for integrin function in these two model organisms should lead to the identification of the minimal set of conserved components that form integrin adhesive structures... - Uncoupling integrin adhesion and signaling: the betaPS cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryoM D Martin-Bermudo
Wellcome Trust Cancer Research Campaign Institute of Cancer and Developmental Biology, and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, UK
Genes Dev 13:729-39. 1999..Therefore, oligomerization of the 47-amino-acid betaPS intracellular domain is sufficient to initiate a signaling pathway that regulates gene expression in the developing embryo... - Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membraneC G Zervas
Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, United Kingdom
J Cell Biol 152:1007-18. 2001..Our data suggest that ILK is a component of the structure linking the cytoskeleton and the plasma membrane at sites of integrin-mediated adhesion... - Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryosA Prokop
Department of Zoology, Downing Street, Cambridge, CB2 3EJ, United Kingdom
Dev Biol 196:58-76. 1998..We suggest that neuromuscular contact in part requires basement membrane adhesion to the general muscle surface, and this form of adhesion is completely abolished in the absence of laminin A... - Genetic analysis of the Drosophila alphaPS2 integrin subunit reveals discrete adhesive, morphogenetic and sarcomeric functionsJ W Bloor
Wellcome CRC Institute, Cambridge, United Kingdom
Genetics 148:1127-42. 1998..One new allele reveals that the PS2 integrin is required for the development of the adult halteres and legs as well as the wing... - kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophinS L Gregory
Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, United Kingdom
J Cell Biol 143:1271-82. 1998..Kakapo is also expressed more widely at a lower level where it is essential for epidermal cell layer stability. These results suggest that the Kakapo protein forms essential links among integrins, actin, and microtubules... - Null mutations in the alpha PS2 and beta PS integrin subunit genes have distinct phenotypesN H Brown
Wellcome CRC Institute, Cambridge, UK
Development 120:1221-31. 1994.... - Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous systemJ A Kaltschmidt
Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Nat Cell Biol 2:7-12. 2000..This observation contradicts the widely held hypothesis that the cleavage furrow is always placed midway between the two centrosomes... - A conserved double-stranded RNA-binding domainD St Johnston
Wellcome Cancer Research Campaign Institute, Cambridge, United Kingdom
Proc Natl Acad Sci U S A 89:10979-83. 1992..On the basis of the binding studies and computer analysis, we have derived a consensus sequence that defines a 65- to 68-amino acid dsRNA-binding domain... - Modulation of integrin activity is vital for morphogenesisM D Martin-Bermudo
Wellcome CRC Institute, Cambridge CB2 1QR, England and Department of Biochemistry, Cambridge University, Cambridge CB2 1QW, England
J Cell Biol 141:1073-81. 1998..These results suggest that the alphaPS2 subunit cytoplasmic domain is required for inside-out regulation of integrin affinity, as has been seen with the integrin alphaIIbbeta3... - Specific tracheal migration is mediated by complementary expression of cell surface proteinsM Boube
Institut de Biologia de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
Genes Dev 15:1554-62. 2001.... - Developmentally regulated alternative splicing of Drosophila integrin PS2 alpha transcriptsN H Brown
Department of Cellular and Developmental Biology, Harvard University Biological Laboratories, Cambridge, Massachusetts 02138
Cell 59:185-95. 1989..We suggest that the variable region A may be important in determining the specificity and affinity of integrin receptors for their ligands... - The localized assembly of extracellular matrix integrin ligands requires cell-cell contactM D Martin-Bermudo
Wellcome CRC Institute, Cambridge University, Tennis Court Road, Cambridge CB2 1QR, UK
J Cell Sci 113:3715-23. 2000..Thus, interaction between cells generates an extracellular environment capable of nucleating extracellular matrix assembly... - Isolation and characterization of the Drosophila translational elongation factor 2 geneY Grinblat
Biological Laboratories, Harvard University, Cambridge, MA 02138
Nucleic Acids Res 17:7303-14. 1989.... - A screen to identify Drosophila genes required for integrin-mediated adhesionE P Walsh
Wellcome CRC Institute and Department of Biochemistry, Cambridge CB2 1QR, United Kingdom
Genetics 150:791-805. 1998..Thus several of these loci are good candidates for genes encoding cytoplasmic proteins required for integrin function... - Migration of the Drosophila primordial midgut cells requires coordination of diverse PS integrin functionsM D Martin-Bermudo
Wellcome CRC Institute and Department of Anatomy, Cambridge University, Tennis Court Road, Cambridge CB2 1QR, UK cam ac uk
Development 126:5161-9. 1999..Thus integrins are involved in mediating migration by creating an optimal substratum for adhesion, adhering to that substratum and possibly by activating Rac and Cdc42... - Intracellular signals direct integrin localization to sites of function in embryonic musclesM D Martin-Bermudo
Wellcome CRC Institute, Cambridge, England
J Cell Biol 134:217-26. 1996..Our results challenge the view that the transmission of signals from the extracellular environment via integrins is required for the organization of the cytoskeleton and the resultant cellular polarity... - Specificity of PS integrin function during embryogenesis resides in the alpha subunit extracellular domainM D Martin-Bermudo
Wellcome CRC Institute, and Department of Biochemistry, Cambridge University, UK
EMBO J 16:4184-93. 1997..We conclude that the two alpha subunits are not equivalent and have distinct functions which reside in the extracellular domains... - Drosophila development. Exploring signalling pathwaysN H Brown
Nature 370:414-5. 1994 - Embryonic expression pattern of a family of Drosophila proteins that interact with a central nervous system regulatory elementS J Bray
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
Genes Dev 3:1130-45. 1989..The antibodies also were used to isolate cDNA clones encoding Elf-1. Alternate forms of Elf-1 mRNA result in at least three protein isoforms...