Research Topics
Genomes and GenesSpecies | Neil BrockdorffSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Genome Environment Browser (GEB): a dynamic browser for visualising high-throughput experimental data in the context of genome featuresDerek Huntley
Centre for Bioinformatics, Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK
BMC Bioinformatics 9:501. 2008..There is a need for novel bioinformatic tools that facilitate these studies...- Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cellsTatyana B Nesterova
Developmental Epigenetics Group, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
Epigenetics Chromatin 4:17. 2011..abstract:.. - SAT in silenceNeil Brockdorff
Department of Biochemistry, University of Oxford, UK
Dev Cell 16:483-4. 2009..In this issue of Developmental Cell, Agrelo et al. show that the nuclear matrix protein SATB1 is a critical determinant of Xist responsiveness... - Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisationY Amy Tang
MRC Clinical Sciences Centre, Faculty of Medicine ICSTM, Hammersmith Hospital, London, UK
Epigenetics Chromatin 3:10. 2010.... - Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivationMariana de Napoles
Developmental Epigenetics Group, MRC Clinical Sciences Centre, ICFM, Hammersmith Hospital, DuCane Road, London W12 ONN, United Kingdom
Dev Cell 7:663-76. 2004..These observations link H2A ubiquitylation, X inactivation, and PRC1 PcG function, suggesting an unanticipated and novel mechanism for chromatin-mediated heritable gene silencing... - Reactivation of the paternal X chromosome in early mouse embryosWinifred Mak
X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London, W12 0NN, UK
Science 303:666-9. 2004..Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions... - Early loss of Xist RNA expression and inactive X chromosome associated chromatin modification in developing primordial germ cellsMariana de Napoles
Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, London, United Kingdom
PLoS ONE 2:e860. 2007.... - Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cellsJulie K Stock
Nuclear Organisation, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
Nat Cell Biol 9:1428-35. 2007..These observations provide an insight into the molecular mechanisms that allow ES cells to self-renew and yet retain the ability to generate multiple lineage outcomes... - Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexesJose Silva
X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
Dev Cell 4:481-95. 2003..Functional analysis demonstrates that Eed-Enx1 is required to establish methylation of histone H3 at lysine 9 and/or lysine 27 on Xi and that this, in turn, is required to stabilize the Xi chromatin structure... - Global hypomethylation of the genome in XX embryonic stem cellsIlona Zvetkova
MRC Clinical Sciences Centre, ICFM, Hammersmith Hospital, DuCane Road, London, W12 ONN, UK
Nat Genet 37:1274-9. 2005..Finally, we show that hypomethylation is associated with reduced levels of the de novo DNA methyltransferases Dnmt3a and Dnmt3b and that ectopic expression of these factors restores global methylation levels... - Skewing X chromosome choice by modulating sense transcription across the Xist locusTatyana B Nesterova
X Inactivation Group, MRC Clinical Sciences Centre, Faculty of Medicine ICSTM, Hammersmith Hospital, London W12 0NN, UK
Genes Dev 17:2177-90. 2003..These results indicate that X chromosome choice is determined by the balance of Xist sense and antisense transcription prior to the onset of random X inactivation... - Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivationClaire E Senner
Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK
Development 138:1541-50. 2011..Analysis of cells that express Xist(INV) RNA demonstrates reduced association of the mutant RNA to the X chromosome, suggesting that conserved sequences in the inverted region are important for Xist RNA localisation... - Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cellsMiguel Casanova
Developmental Epigenetics Group, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK
Development 138:1471-82. 2011..The role of Pcl2 in PRC2 targeting in ES cells is critically dependent on a conserved PHD finger domain, suggesting that Pcl2 might function through the recognition of a specific chromatin configuration... - X-chromosome inactivation: closing in on proteins that bind Xist RNANeil Brockdorff
X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, DuCane Road, W12 0NN, London, UK
Trends Genet 18:352-8. 2002..A key issue has been to identify the factors that interact with Xist RNA to initiate heritable gene silencing. This review discusses recent progress that has put this goal in sight... - RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3Ligia Tavares
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Cell 148:664-78. 2012..We discuss the implications of these findings for understanding recruitment and function of Polycomb repressors... - Xist gene regulation at the onset of X inactivationClaire E Senner
MRC Clinical Sciences Centre, Imperial College, Hammersmith Campus, London, UK
Curr Opin Genet Dev 19:122-6. 2009..This review focuses on recent advances in this area and discusses the implications for our understanding of Xist gene regulation at the onset of X inactivation... - Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulatorsDavid Landeira
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN UK
Nat Cell Biol 12:618-24. 2010..Collectively, these data indicate that transcriptional priming of bivalent genes in pluripotent ES cells is Jarid2-dependent, and suggests that priming is critical for subsequent multi-lineage differentiation... - Enox, a novel gene that maps 10 kb upstream of Xist and partially escapes X inactivationColette M Johnston
X Inactivation Group, MRC Clinical Sciences Centre, Faculty of Medicine ICSTM, Hammersmith Hospital, Du Cane Road, London, UK
Genomics 80:236-44. 2002..In female somatic tissue Enox partially escapes from X inactivation. We discuss the implications of these findings in relation to our understanding of the Xic... - Chromosome silencing mechanisms in X-chromosome inactivation: unknown unknownsNeil Brockdorff
Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK
Development 138:5057-65. 2011..Taking this point as a theme, I discuss our current understanding of the molecular mechanism of chromosome silencing in X-chromosome inactivation and focus on topics where new findings are challenging the prevailing view... - A scaffold for X chromosome inactivationAnna Tattermusch
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Hum Genet 130:247-53. 2011..In this review we provide a perspective on these studies in the context of previous work on chromosome/nuclear architecture in XCI... - Xist expression and macroH2A1.2 localisation in mouse primordial and pluripotent embryonic germ cellsTatyana B Nesterova
X Inactivation Group, MRC Clinical Sciences Centre, Faculty of Medicine ICSTM, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
Differentiation 69:216-25. 2002..2. Although macroH2A1.2 expression was observed in PGCs, no significant localisation to the inactive X was detected at any stage. We discuss these results in the context of understanding X chromosome reactivation... - Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cellsWinifred Mak
X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London W12 0NN, United Kingdom
Curr Biol 12:1016-20. 2002..The association of Eed/Enx1 complexes is mitotically stable, suggesting a mechanism for the maintenance of imprinted X inactivation in these cells... - Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivationJacqueline E Mermoud
X Inactivation Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
Curr Biol 12:247-51. 2002..Here we show that H3-K9 methylation is a very early event in the process of X inactivation, which closely parallels the onset of Xist RNA accumulation...