Research Topics
| Dennis BraySummaryAffiliation: University of Cambridge Country: UK Publications
Research Grants
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Detail Information
Publications
The cell as a thermostat: how much does it know?Dennis Bray
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Adv Exp Med Biol 736:193-8. 2012..This information is far richer than anything carried by a thermostat and closer to the 'knowledge' that higher animals have about the world...- How the "melting" and "freezing" of protein molecules may be used in cell signalingDennis Bray
Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
ACS Chem Biol 3:89-91. 2008..We discuss the thermodynamic basis for this effect and argue that the "freezing" or "melting" of protein structure may be the language of signaling... - The chemotactic behavior of computer-based surrogate bacteriaDennis Bray
Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
Curr Biol 17:12-9. 2007..In many species of bacteria, this occurs when extracellular signals are detected by transmembrane receptors and relayed to flagellar motors, which control the cell's swimming behavior... - Flexible peptides and cytoplasmic gelsDennis Bray
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK
Genome Biol 6:106. 2005..Unstructured, flexible polypeptides are likely to be functionally important and may cause local cytoplasmic regions to become gel-like... - Conformational spread: the propagation of allosteric states in large multiprotein complexesDennis Bray
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
Annu Rev Biophys Biomol Struct 33:53-73. 2004..We suggest that conformational spread could provide the basis of a solid-state "circuitry" in a living cell, able to integrate biochemical and biophysical events over hundreds of protein molecules... - Balls and chains--a mesoscopic approach to tethered protein domainsBernhard Windisch
Department of Physics, Cavendish Laboratory, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
Biophys J 91:2383-92. 2006..The possible biological significance of these and other results is discussed... - Signal amplification in a lattice of coupled protein kinasesJacki P Goldman
Department of Physiology, Development, and Neuroscience, University of Cambridge, UK
Mol Biosyst 5:1853-9. 2009..We test this idea with detailed, molecular-based stochastic simulations and show that it gives an accurate reproduction of signalling in this system, including ligand-specific adaptation... - A spatially extended stochastic model of the bacterial chemotaxis signalling pathwayThomas S Shimizu
Department of Zoology, University of Cambridge, UK
J Mol Biol 329:291-309. 2003..The model also has some of the properties of a cellular automaton and shows an unexpected emergence of spatial patterns of methylation within the receptor lattice... - Simulated diffusion of phosphorylated CheY through the cytoplasm of Escherichia coliKaren Lipkow
Department of Anatomy, University of Cambridge, Downing St, Cambridge CB2 3DY, United Kingdom
J Bacteriol 187:45-53. 2005..These and other results are left as predictions for future experiments... - Binding and diffusion of CheR molecules within a cluster of membrane receptorsMatthew D Levin
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
Biophys J 82:1809-17. 2002..We explore the possible consequences of this motion, which we term "molecular brachiation", for chemotactic adaptation and suggest that a similar mechanism may be operative in other large assemblies of protein molecules... - Size and composition of membrane protein clusters predicted by Monte Carlo analysisJacki Goldman
Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
Eur Biophys J 33:506-12. 2004..Our results suggest that the self-assembly of microdomains might require a critical level of subunits and that for optimal co-aggregation, proteins should be present in the membrane in the correct stoichiometric ratios... - Genomics. Molecular prodigalityDennis Bray
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
Science 299:1189-90. 2003 - Stochastic simulation of chemical reactions with spatial resolution and single molecule detailSteven S Andrews
Department of Zoology, University of Cambridge, UK
Phys Biol 1:137-51. 2004..Capabilities of these methods are demonstrated with simulations of a simple bimolecular reaction and the Lotka-Volterra system... - Modelling the bacterial chemotaxis receptor complexThomas Simon Shimizu
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Novartis Found Symp 247:162-77; discussion 177-81, 198-206, 244-52. 2002..The adaptation reactions may also exploit the proximity of receptor molecules, and a hypothetical mechanism by which this may occur is currently being tested... - Molecular networks: the top-down viewDennis Bray
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Science 301:1864-5. 2003..Network theory can give a useful overview of how a biological system works. But to make testable predictions, we need the details... - Bacterial chemotaxis and the question of gainDennis Bray
Department of Zoology, University of Cambridge, Cambridge, United Kingdom
Proc Natl Acad Sci U S A 99:7-9. 2002
Research Grants
- MOLECULAR EVENTS IN A DISCRETE CYTOPLASMIC SPACEDennis Bray; Fiscal Year: 2004....
- BACTERIAL CHEMOTAXIS: A COMPUTER-BASED STUDYDennis Bray; Fiscal Year: 2007..Moreover, the intimate involvement of computational and experimental approaches in our study will both contribute to, and derive benefit from, the raidly expanding area of systems biology. ..