Research Topics
Genomes and Genes | Rachel L BatterhamSummaryAffiliation: University College London Country: UK Publications
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Publications
Gut hormone PYY(3-36) physiologically inhibits food intakeRachel L Batterham
Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
Nature 418:650-4. 2002..Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway...- Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parametersCarel W le Roux
Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
Ann Surg 243:108-14. 2006..CONCLUSIONS: Following RYGB and JIB, a pleiotropic endocrine response may contribute to the improved glycemic control, appetite reduction, and long-term changes in body weight... - PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humansRachel L Batterham
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
Nature 450:106-9. 2007..An increased understanding of how such homeostatic and higher brain functions are integrated may pave the way for the development of new treatment strategies for obesity... - Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgeryWilliam R Scott
Centre for Obesity Research, Dept of Medicine, Rayne Institute, University College London, WC1E 6JJ, UK
Am J Physiol Regul Integr Comp Physiol 301:R15-27. 2011..Here we review mechanisms of weight loss and T2D resolution after Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy bariatric surgery, two markedly different procedures with robust clinical outcomes... - Critical role for peptide YY in protein-mediated satiation and body-weight regulationRachel L Batterham
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, WC1E 6JJ, United Kingdom
Cell Metab 4:223-33. 2006..Our findings suggest that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity... - AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neuronsMarc Claret
Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
J Clin Invest 117:2325-36. 2007.... - Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neuronsHind Al-Qassab
Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, UK
Cell Metab 10:343-54. 2009..These results demonstrate distinct metabolic roles for the p110alpha and p110beta isoforms of PI3K in hypothalamic energy regulation... - Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YYKeval Chandarana
Centre for Obesity Research, Department of Medicine, University College London, Rayne Institute, London, UK
Diabetes 60:810-8. 2011..To evaluate PYY's role in mediating weight loss post-GIBP, we undertook GIBP surgery in PyyKO mice... - The role of gut hormones in the regulation of body weight and energy homeostasisEfthimia Karra
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London, United Kingdom
Mol Cell Endocrinol 316:120-8. 2010.... - Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in miceJames Cantley
Centre for Diabetes and Endocrinology, Faculty of Medicine, Rayne Institute, University College London, London, UK
J Clin Invest 119:125-35. 2009..These data suggest that VHL/HIF oxygen-sensing mechanisms play a critical role in glucose homeostasis and that activation of this pathway in response to decreased islet oxygenation may contribute to beta cell dysfunction... - Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null miceColin Selman
Centre for Diabetes and Endocrinology, Department of Medicine, Rayne Institute, University College London, University St, London, UK
FASEB J 22:807-18. 2008..Our results therefore suggest that IRS1 signaling is an evolutionarily conserved pathway regulating mammalian life span and may be a point of intervention for therapies with the potential to delay age-related processes... - Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy malesDavid R Broom
Department of Medicine, School of Sport and Exercise Sciences, Loughborough Univ, Leicestershire, LE11 3TU, UK
Am J Physiol Regul Integr Comp Physiol 296:R29-35. 2009..These findings suggest ghrelin and PYY may regulate appetite during and after exercise, but further research is required to establish whether exercise-induced changes in ghrelin and PYY influence subsequent food intake... - The role of peptide YY in appetite regulation and obesityEfthimia Karra
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
J Physiol 587:19-25. 2009..Taken together these findings, coupled with the retained responsiveness of obese subjects to the effects of PYY3-36, suggest that targeting the PYY system may offer a therapeutic strategy to help treat obesity... - Ribosomal protein S6 kinase 1 signaling regulates mammalian life spanColin Selman
Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
Science 326:140-4. 2009..Our results demonstrate that S6K1 influences healthy mammalian life-span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging... - Gaining new insights into food reward with functional neuroimagingMarianne T Neary
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London, UK
Forum Nutr 63:152-63. 2010..Finally, we discuss the potential to use such information to guide development of pharmaceuticals, functional foods and life-style modifications... - Subject standardization, acclimatization, and sample processing affect gut hormone levels and appetite in humansKeval Chandarana
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
Gastroenterology 136:2115-26. 2009..However, controversy surrounds the effects that adiposity, dietary manipulations, and bariatric surgery have on their circulating concentrations. We sought to determine whether these discrepancies are due to methodologic differences... - Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgeryEfthimia Karra
Department of Medicine, University College London, Centre for Obesity Research, 5 University Street, London WC1E 6JJ, United Kingdom
Trends Endocrinol Metab 21:337-44. 2010..Understanding the mechanisms mediating these beneficial outcomes of bariatric surgery could result in new non-surgical treatment strategies for obesity and T2DM... - The role of insulin receptor substrate 2 in hypothalamic and beta cell functionAgharul I Choudhury
Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
J Clin Invest 115:940-50. 2005..Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis... - Peptide YY: food for thoughtMarianne T Neary
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Building, London, United Kingdom
Physiol Behav 97:616-9. 2009..Taken in concert, these findings suggest that the PYY system may hold significant potential in the treatment and prevention of obesity... - Gut hormones: implications for the treatment of obesityMarianne T Neary
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
Pharmacol Ther 124:44-56. 2009..Up-to-date outcomes of clinical trials are evaluated and directions for the future suggested... - Metabolic state alters economic decision making under risk in humansMkael Symmonds
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
PLoS ONE 5:e11090. 2010..We hypothesised that baseline metabolic reserves and alterations in metabolic state would systematically modulate decision-making and financial risk-taking in humans... - Inhibition of food intake in obese subjects by peptide YY3-36Rachel L Batterham
Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
N Engl J Med 349:941-8. 2003..001). CONCLUSIONS: We found that obese subjects were not resistant to the anorectic effects of PYY. Endogenous PYY levels were low in the obese subjects, suggesting that PYY deficiency may contribute to the pathogenesis of obesity... - Oxyntomodulin suppresses appetite and reduces food intake in humansMark A Cohen
Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom W12 0NN
J Clin Endocrinol Metab 88:4696-701. 2003..0001). Elevated levels of endogenous OXM associated with disorders of the gastrointestinal tract may contribute to anorexia...