Anne C Barton

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure
    Neil Shephard
    ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom
    BMC Genet 4:S26. 2003
  2. ncbi High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 10:1901-6. 2001
  3. ncbi Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:748-52. 2004
  4. ncbi Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population
    A Barton
    ARC EU, Stopford Building, University of Manchester, Manchester, UK
    Brain 127:1717-22. 2004
  5. ncbi Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:752-8. 2005
  6. ncbi A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:1117-21. 2004
  7. ncbi Genetic epidemiology. Psoriatic arthritis
    Anne C Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, UK
    Arthritis Res 4:247-51. 2002
  8. ncbi Genetic approaches to the investigation of rheumatoid arthritis
    Anne Barton
    ARC Epidemiology Unit, University of Manchester, Manchester, UK
    Curr Opin Rheumatol 14:260-9. 2002
  9. ncbi Commentary on "Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus", by RR Graham et al
    Anne C Barton
    Arthritis and Rheumatism Campaign Epidemiology Unit, Stopford Building, University of Manchester M13 9PT, Manchester, UK
    Arthritis Res 4:84-6. 2002
  10. ncbi Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?
    Stephen Eyre
    ARC EU, University of Manchester, UK
    Arthritis Res Ther 8:R117. 2006

Detail Information

Publications46

  1. ncbi Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure
    Neil Shephard
    ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom
    BMC Genet 4:S26. 2003
    ....
  2. ncbi High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 10:1901-6. 2001
    ..The difficult task of identifying a disease mutation from a linkage result should, in this case at least, be facilitated by the combined use of animal and human based investigations...
  3. ncbi Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:748-52. 2004
    ..The aim of this study was to investigate the association of the CTLA-4 polymorphism with RA...
  4. ncbi Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population
    A Barton
    ARC EU, Stopford Building, University of Manchester, Manchester, UK
    Brain 127:1717-22. 2004
    ..Our results suggest that the promoter and proximal gene region should be not only included but prioritized in any screening strategy...
  5. ncbi Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:752-8. 2005
    ..The purpose of this study was to investigate the association between the OCTN locus and RA in a Caucasian population...
  6. ncbi A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:1117-21. 2004
    ..In the present study, we investigated the association of single-nucleotide polymorphisms (SNPs) in the PADI4 gene with RA in a UK population...
  7. ncbi Genetic epidemiology. Psoriatic arthritis
    Anne C Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, UK
    Arthritis Res 4:247-51. 2002
    ..These aetiological factors may be genetic and/or environmental, and in this review, the evidence for distinct psoriatic arthritis genetic susceptibility factors is considered...
  8. ncbi Genetic approaches to the investigation of rheumatoid arthritis
    Anne Barton
    ARC Epidemiology Unit, University of Manchester, Manchester, UK
    Curr Opin Rheumatol 14:260-9. 2002
    ..This review summarizes the results of many of the HLA and non-HLA studies and tries to draw lessons from the investigation of genetic susceptibility factors in other complex diseases...
  9. ncbi Commentary on "Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus", by RR Graham et al
    Anne C Barton
    Arthritis and Rheumatism Campaign Epidemiology Unit, Stopford Building, University of Manchester M13 9PT, Manchester, UK
    Arthritis Res 4:84-6. 2002
    ..3 Mb. This commentary discusses their approach and identifies lessons that may be applicable to the investigation of other complex diseases...
  10. ncbi Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?
    Stephen Eyre
    ARC EU, University of Manchester, UK
    Arthritis Res Ther 8:R117. 2006
    ....
  11. ncbi Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites
    Sally John
    University of Manchester, Manchester, United Kingdom
    Am J Hum Genet 75:54-64. 2004
    ..The high SNP density allows loci to be defined more precisely and provides a partial scaffold for association studies, substantially reducing the resource requirement for gene-mapping studies...
  12. ncbi PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population
    Marian L Burr
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, UK
    Ann Rheum Dis 69:666-70. 2010
    ..However, studies in European populations have produced conflicting results. This study explored the association of the PADI4 genotype with RA in a large UK Caucasian population...
  13. ncbi Investigation of susceptibility loci identified in the UK rheumatoid arthritis whole-genome scan in a further series of 217 UK affected sibling pairs
    Stephen Eyre
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 50:729-35. 2004
    ..03). CONCLUSION: These results support the evidence for heterogeneity of RA. This information will inform the future design of association-based investigations as the search for disease genes in the linked regions begins...
  14. ncbi Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis
    Pauline Ho
    University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Arthritis Rheum 52:3596-602. 2005
    ..The SLC22A4 gene has also been associated with rheumatoid arthritis. This study was undertaken to further elucidate associations of PsA with Crohn's disease susceptibility genes...
  15. ncbi Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK
    Anne Hinks
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 66:683-6. 2007
    ....
  16. ncbi Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes
    Anne Barton
    University of Manchester, Manchester, UK
    Hum Mol Genet 18:2518-22. 2009
    ..94, P = 1.1 x 10(-4) and OR 0.86, 95% CI 0.79-0.94, P = 5.4 x 10(-4), respectively). These findings take the number of established RA susceptibility loci to 13, only one of which has not been associated with other autoimmune diseases...
  17. ncbi Investigation of association of the IL12B and IL23R genes with psoriatic arthritis
    Charlotte Filer
    University of Manchester, Manchester, UK
    Arthritis Rheum 58:3705-9. 2008
    ..The aim of this study was to determine whether these variants are also associated with susceptibility to psoriatic arthritis (PsA)...
  18. ncbi Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study
    Gisela Orozco
    Epidemiology Unit, Faculty of Medical and Human Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:813-6. 2010
    ..The aim of the current study was to validate these potential RA susceptibility markers in a UK population...
  19. ncbi Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:251-7. 2009
    ..The aim of this study was to determine whether SNPs within the IL2RA/CD25 gene are associated with juvenile idiopathic arthritis (JIA)...
  20. ncbi Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p
    William Brintnell
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:3823-30. 2004
    ..To investigate whether the large linkage peak on chromosome 6p harbors rheumatoid arthritis (RA) susceptibility loci in addition to the well-characterized HLA-DRB1 gene...
  21. ncbi Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis
    Anne Hinks
    Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1049-53. 2010
    ..Rheumatoid arthritis (RA) is an autoimmune disease that shares similar clinical and pathological features with JIA and, therefore, recently identified confirmed RA susceptibility loci are also excellent JIA candidate loci...
  22. ncbi Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment
    Rachael J L Tan
    Arthritis Research Campaign Epidemiology Unit, Stopford Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1029-35. 2010
    ..The aim of the current study was to investigate the association of markers within confirmed RA susceptibility loci with the response to anti-TNF treatment...
  23. ncbi Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility
    Anne Barton
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Hum Mol Genet 17:2274-9. 2008
    ..The effect sizes are less than those reported previously but are likely to be a more accurate reflection of the true effect size given the larger size of the cohort investigated in the current study...
  24. ncbi Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis
    Tracey M Farragher
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 58:359-69. 2008
    ..To examine the role of the variants of the PTPN22 and HLA-DRB1 genes as predictors of mortality in inflammatory polyarthritis (IP) and rheumatoid arthritis (RA)...
  25. ncbi Rheumatoid arthritis association at 6q23
    Wendy Thomson
    Arthritis Research Campaign ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Nat Genet 39:1431-3. 2007
    ..1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3)...
  26. ncbi Investigation of association between the TRAF family genes and RA susceptibility
    Catherine Potter
    Arthritis Research Campaign Epidemiology Unit, Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 66:1322-6. 2007
    ..A study was undertaken to investigate the association between single nucleotide polymorphisms (SNPs) spanning six TRAF genes and RA in a British population...
  27. ncbi Investigation of the MHC2TA gene, associated with rheumatoid arthritis in a Swedish population, in a UK rheumatoid arthritis cohort
    Stephen Eyre
    University of Manchester, Manchester, UK
    Arthritis Rheum 54:3417-22. 2006
    ..Therefore, we undertook this study to investigate the association of the MHC2TA gene promoter with RA in a UK Caucasian population...
  28. ncbi Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23
    Gisela Orozco
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 18:2693-9. 2009
    ..This is the first study to show that the confirmed loci from the GWA studies, that confer only a modest effect size, could harbour a significantly greater effect once the effect of additional risk variants are accounted for...
  29. ncbi Fine mapping of genes within the IDDM8 region in rheumatoid arthritis
    Anne Hinks
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Arthritis Res Ther 8:R145. 2006
    ..Our study has failed to detect evidence of association with any of the known genes mapping to the IDDM8 locus with RA...
  30. ncbi Characterisation of the genomic architecture of human chromosome 17q and evaluation of different methods for haplotype block definition
    Eleftheria Zeggini
    Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
    BMC Genet 6:21. 2005
    ..5 kb, we constructed haplotype block maps using published methods and additional methods we have developed. Haplotype tagging SNPs (htSNPs) were identified for each map...
  31. ncbi Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:258-63. 2009
    ..The purpose of this study was to perform a systematic search of the genome to identify novel susceptibility loci for JIA...
  32. ncbi Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
    Anne Barton
    Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK
    Nat Genet 40:1156-9. 2008
    ....
  33. ncbi HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis
    Pauline Y P C Ho
    ARC EU, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 66:807-11. 2007
    ..Human leucocyte antigen (HLA) genes predict disease severity in psoriasis (HLA-Cw6) and rheumatoid arthritis (shared epitope (SE)), but the situation is unclear for psoriatic arthritis (PsA)...
  34. ncbi Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom
    Kirsten MacKay
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Arthritis Rheum 46:632-9. 2002
    ..To undertake a systematic whole-genome screen to identify regions exhibiting genetic linkage to rheumatoid arthritis (RA)...
  35. ncbi Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:1694-9. 2005
    ....
  36. ncbi Benefit of early treatment in inflammatory polyarthritis patients with anti-cyclic citrullinated peptide antibodies versus those without antibodies
    Tracey M Farragher
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Care Res (Hoboken) 62:664-75. 2010
    ..To compare the clinical utility of anti-cyclic citrullinated peptide (anti-CCP) antibodies and rheumatoid factor (RF) testing in predicting both functional outcome and response to treatment in early inflammatory polyarthritis (IP) patients...
  37. ncbi Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis
    A Hinks
    Arthritis Research Campaign Epidemiology Unit ARC EU, University of Manchester, Manchester, UK
    Genes Immun 11:194-8. 2010
    ..All results require validation in independent JIA data sets. Further characterisation of the specific causal variants will be required before functional studies can be performed...
  38. ncbi Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci
    Annie McClure
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Rheumatology (Oxford) 48:1369-74. 2009
    ..The largest single effect is conferred by SE. We hypothesized that combinations of susceptibility alleles may increase risk over and above that of any individual locus alone...
  39. ncbi Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients
    John D Bowes
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Pharmacogenet Genomics 19:319-23. 2009
    ..We conclude that analysis of the common variation in the selected candidate genes did not provide strong evidence to implicate their involvement in varying patient response to anti-TNF treatment...
  40. ncbi Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients
    Tracey M Farragher
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    Arthritis Care Res (Hoboken) 62:676-82. 2010
    ....
  41. ncbi Update on the genetic risk factors for rheumatoid arthritis
    Gisela Orozco
    Arthritis Research Campaign Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Expert Rev Clin Immunol 6:61-75. 2010
    ..Finally, we discuss what still needs to be accomplished before a more complete picture of the genetic risk to RA can be attained...
  42. ncbi Polymorphisms in the mannose binding lectin (MBL) gene are not associated with radiographic erosions in rheumatoid or inflammatory polyarthritis
    Anne Barton
    Arthritis and Rheumatism Campaign Epidemiology Unit, University of Manchester, Manchester, UK 1 ser man ac uk
    J Rheumatol 31:442-7. 2004
    ....
  43. ncbi Approaches to identifying genetic predictors of clinical outcome in rheumatoid arthritis
    Anne Barton
    School of Epidemiology and Health Sciences, University of Manchester, Manchester, England, UK
    Am J Pharmacogenomics 3:181-91. 2003
    ....
  44. ncbi Increasing age at symptom onset is associated with worse radiological damage at presentation in patients with early inflammatory polyarthritis
    Marwan Bukhari
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 66:389-93. 2007
    ..Increasing age at onset has been associated with worse outcome in rheumatoid arthritis, although there are few data from unselected inception cohorts...
  45. ncbi Genetic susceptibility factors for psoriatic arthritis
    Madhura Castelino
    ARC Epidemiology Unit, Manchester Academy of Health Sciences, The University of Manchester, Manchester, UK
    Curr Opin Rheumatol 22:152-6. 2010
    ..However, using a variety of approaches, some confirmed associations have now been identified with PsA susceptibility, making a review of these recent developments timely...
  46. ncbi The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register
    Darren Plant
    ARC Epidemiology Unit, Manchester Academic Health Sciences Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 50:78-84. 2011
    ..We therefore sought to investigate the role of recently identified RA susceptibility SNP markers in predicting erosive outcome in patients with recent-onset inflammatory polyarthritis (IP)...