Research Topics
| K S BabuSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
Aspirin and asthmaK S Babu
Department of Respiratory Cell and Molecular Biology, University of Southampton, Southampton General Hospital, Southampton, UK
Chest 118:1470-6. 2000..This review covers the latest understanding of pathogenesis, clinical features, and management of AIA...
Role of tumor necrosis factor alpha in asthmaK Suresh Babu
Respiratory Cell and Molecular Biology Infection, Inflammation and Repair, Southampton General Hospital, Level D, Centre Block, Mailpoint 810, Southampton SO16 6YD, UK
Immunol Allergy Clin North Am 24:583-97, v-vi. 2004..This article examines the role of TNF-alpha in asthma and the effects of blocking TNF-alpha as a possible therapeutic option in patients with severe corticosteroid-dependent asthma...
Drug-induced airway diseasesK Suresh Babu
Mail Point 810, Level D, Centre Block, Southampton General Hospital, Southampton SO16 6YD, UK
Clin Chest Med 25:113-22. 2004..In view of the constantly-evolving therapies, an active policy to identify and report adverse effects is essential to develop management strategies and treatment recommendations...
Inhaled synthetic surfactant abolishes the early allergen-induced response in asthmaK S Babu
Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, UK
Eur Respir J 21:1046-9. 2003..Exogenous surfactant administration could serve as a useful adjunct in controlling the early allergen-induced symptoms in patients with allergic asthma...
Newer therapies for asthma: a focus on anti-IgEK Suresh Babu
Respiratory Cell and Molecular Biology, Southampton General Hospital, UK
Indian J Chest Dis Allied Sci 44:107-15. 2002..This review gives a brief overview of the newer therapies under investigation with special reference to omalizumab in the treatment of allergic asthma...
Management of cutaneous drug reactionsK S Babu
Medical Specialities, Southampton General Hospital, Mail Point 810, Level D, Centre Block, Southampton SO16 6YD, UK
Curr Allergy Asthma Rep 2:26-33. 2002..The management of a cutaneous drug eruption is very much individualized, based on the clinical setting. This review aims to provide a general approach to the patient with a presumed cutaneous drug reaction...
Omalizumab, a novel anti-IgE therapy in allergic disordersK S Babu
Department of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, UK
Expert Opin Biol Ther 1:1049-58. 2001..Omalizumab also demonstrated a high level of safety in adults, adolescents and children with a side effect profile no different from the placebo. Its development is an exciting milestone in the treatment of allergic diseases...
The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trialJ B Morjaria
Infection, Inflammation and Repair Division, Southampton University Hospitals Trust, Southampton, UK
Thorax 63:584-91. 2008..Tumour necrosis factor alpha (TNFalpha) is a cytokine recognised as a therapeutic target in chronic inflammatory diseases...
Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthmaP H Howarth
Allergy and Inflammation Research, Division of Infection, Inflammation and Repair, School of Medicine, F Level South Block (810, Southampton General Hospital, Southampton SO16 6YD, UK
Thorax 60:1012-8. 2005..CONCLUSIONS: These findings may be of clinical significance in identifying TNFalpha as a new therapeutic target in subjects with severe asthma. The effects of anti-TNF treatment now require confirmation in placebo controlled studies...
Absence of respiratory effects with ivabradine in patients with asthmaK Suresh Babu
Infection, Inflammation and Repair, Southampton General Hospital, Southampton, UK
Br J Clin Pharmacol 66:96-101. 2008..Ivabradine has been recently approved for the treatment of stable angina. This study assessed the effects of repeated administration of ivabradine on lung function in patients with asthma...
The role of anti-IgE therapies in the treatment of asthmaK Suresh Babu
Department of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton SO16 6YD
Hosp Med 63:483-6. 2002....
The role of allergy in the development of airway inflammation in childrenK Suresh Babu
Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, UK
Paediatr Respir Rev 4:40-6. 2003..The persistent airway inflammation leads to tissue remodelling and airway hyperresponsiveness, the clinical sine qua non of asthma...
Technology evaluation: mepolizumab, GlaxoSmithKlineGnanasegaram Gnanakumaran
Mail Point 810, Level D, Centre Block, Southampton General Hospital, Southampton, SO16 6YD, UK
Curr Opin Mol Ther 5:321-5. 2003..Phase II trials in asthma were underway by April 1998 and by March 2002, phase II trials had also been initiated in atopic dermatitis...
