D D Axe

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi An irregular beta-bulge common to a group of bacterial RNases is an important determinant of stability and function in barnase
    D D Axe
    MRC Center, Cambridge University Chemical Laboratory and Cambridge Center for Protein Engineering, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 286:1471-85. 1999
  2. ncbi Extreme functional sensitivity to conservative amino acid changes on enzyme exteriors
    D D Axe
    MRC Centre, Centre for Protein Engineering, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 301:585-95. 2000

Collaborators

Detail Information

Publications2

  1. ncbi An irregular beta-bulge common to a group of bacterial RNases is an important determinant of stability and function in barnase
    D D Axe
    MRC Center, Cambridge University Chemical Laboratory and Cambridge Center for Protein Engineering, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 286:1471-85. 1999
    ..If this is a general characteristic of the structure-function relationship, it may pose a formidable obstacle to the de novo design of new enzymes...
  2. ncbi Extreme functional sensitivity to conservative amino acid changes on enzyme exteriors
    D D Axe
    MRC Centre, Centre for Protein Engineering, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 301:585-95. 2000
    ..Homologues sharing less than about two-thirds sequence identity should probably be viewed as distinct designs with their own sets of optimising features...