Darren L Asquith

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis
    Darren L Asquith
    Glasgow Biomedical Research Center, Division of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow, UK
    Arthritis Rheum 60:2655-65. 2009
  2. ncbi Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, GBRC, University of Glasgow, Glasgow, United Kingdom
    Circ Res 107:650-8. 2010
  3. ncbi Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis
    Darren L Asquith
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 62:472-7. 2010
  4. ncbi IL-33 induces skin inflammation with mast cell and neutrophil activation
    Axel J Hueber
    Glasgow Biomedical Research Centre, University of Glasgow, UK
    Eur J Immunol 41:2229-37. 2011
  5. ncbi Simultaneous activation of the liver X receptors (LXR? and LXR?) drives murine collagen-induced arthritis disease pathology
    Darren L Asquith
    Correspondence to Dr Darren L Asquith, Glasgow Biomedical Research Centre, Institute of Immunity, Infection and Inflammation, College of Medical, Veterinary and Life Sciences, 120 University Place, University of Glasgow, Glasgow G12 8TA, UK
    Ann Rheum Dis 70:2225-8. 2011
  6. ncbi Mast cells express IL-17A in rheumatoid arthritis synovium
    Axel J Hueber
    Division of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 184:3336-40. 2010
  7. ncbi Animal models of rheumatoid arthritis
    Darren L Asquith
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Eur J Immunol 39:2040-4. 2009
  8. ncbi IL-33 reduces the development of atherosclerosis
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, UK
    J Exp Med 205:339-46. 2008
  9. ncbi MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
    Mariola Kurowska-Stolarska
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 108:11193-8. 2011
  10. ncbi Emerging cytokine targets in rheumatoid arthritis
    Darren L Asquith
    Glasgow Biomedical Research Centre, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Curr Opin Rheumatol 19:246-51. 2007

Collaborators

Detail Information

Publications10

  1. ncbi Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis
    Darren L Asquith
    Glasgow Biomedical Research Center, Division of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow, UK
    Arthritis Rheum 60:2655-65. 2009
    ..This study was therefore undertaken to explore the biologic mechanisms of LXRs in vivo and in vitro in an experimental inflammatory arthritis model...
  2. ncbi Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, GBRC, University of Glasgow, Glasgow, United Kingdom
    Circ Res 107:650-8. 2010
    ..The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear...
  3. ncbi Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis
    Darren L Asquith
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 62:472-7. 2010
    ..To determine whether elevated serum lipid levels resulting from feeding animals a high-fat diet can affect the inflammatory process in C57BL/6 (B6) wild-type (WT) and B6 ApoE(-/-) mouse models of collagen-induced arthritis (CIA)...
  4. ncbi IL-33 induces skin inflammation with mast cell and neutrophil activation
    Axel J Hueber
    Glasgow Biomedical Research Centre, University of Glasgow, UK
    Eur J Immunol 41:2229-37. 2011
    ..These results therefore demonstrate that IL-33 may play a role in psoriasis-like plaque inflammation. IL-33 targeting may provide a new treatment strategy for psoriasis...
  5. ncbi Simultaneous activation of the liver X receptors (LXR? and LXR?) drives murine collagen-induced arthritis disease pathology
    Darren L Asquith
    Correspondence to Dr Darren L Asquith, Glasgow Biomedical Research Centre, Institute of Immunity, Infection and Inflammation, College of Medical, Veterinary and Life Sciences, 120 University Place, University of Glasgow, Glasgow G12 8TA, UK
    Ann Rheum Dis 70:2225-8. 2011
    ..It has previously been shown that dual activation of the Liver X Receptors (LXR? and LXR?) by the agonist, GW3965, enhances pathology in a murine model of collagen-induced arthritis...
  6. ncbi Mast cells express IL-17A in rheumatoid arthritis synovium
    Axel J Hueber
    Division of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 184:3336-40. 2010
    ....
  7. ncbi Animal models of rheumatoid arthritis
    Darren L Asquith
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Eur J Immunol 39:2040-4. 2009
    ..Here, we describe these animal models and discuss their advantages and limitations...
  8. ncbi IL-33 reduces the development of atherosclerosis
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, UK
    J Exp Med 205:339-46. 2008
    ..In conclusion, IL-33 may play a protective role in the development of atherosclerosis via the induction of IL-5 and ox-LDL antibodies...
  9. ncbi MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
    Mariola Kurowska-Stolarska
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 108:11193-8. 2011
    ..Our data therefore identify a role of miR-155 in clinical and experimental arthritis and suggest that miR-155 may be an intriguing therapeutic target...
  10. ncbi Emerging cytokine targets in rheumatoid arthritis
    Darren L Asquith
    Glasgow Biomedical Research Centre, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Curr Opin Rheumatol 19:246-51. 2007
    ..Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive to remission induction, requires that further therapeutic targets be identified...