Timothy R Arnett

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Isolated osteoclast cultures
    Astrid Hoebertz
    Department of Anatomy and Developmental Biology, University College London, London, UK
    Methods Mol Med 80:53-64. 2003
  2. ncbi Regulation of bone cell function by acid-base balance
    Tim Arnett
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Proc Nutr Soc 62:511-20. 2003
  3. ncbi Extracellular pH regulates bone cell function
    Timothy R Arnett
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    J Nutr 138:415S-418S. 2008
  4. ncbi Hypoxia is a major stimulator of osteoclast formation and bone resorption
    Timothy R Arnett
    Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
    J Cell Physiol 196:2-8. 2003
  5. ncbi Acidosis, hypoxia and bone
    Timothy R Arnett
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Arch Biochem Biophys 503:103-9. 2010
  6. ncbi Hypoxia stimulates vesicular ATP release from rat osteoblasts
    Isabel R Orriss
    Department of Cell and Developmental Biology, University College London, London, UK
    J Cell Physiol 220:155-62. 2009
  7. ncbi Osteoblast responses to nucleotides increase during differentiation
    Isabel R Orriss
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Bone 39:300-9. 2006
  8. ncbi Purinergic signalling and bone remodelling
    Isabel R Orriss
    Department of Cell and Developmental Biology, University College London, London, UK
    Curr Opin Pharmacol 10:322-30. 2010
  9. ncbi Inhibition of osteoblast function in vitro by aminobisphosphonates
    Isabel R Orriss
    Department of Cell and Developmental Biology, University College London, London, UK
    J Cell Biochem 106:109-18. 2009
  10. ncbi Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate
    Isabel R Orriss
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    Endocrinology 148:4208-16. 2007

Collaborators

Detail Information

Publications18

  1. ncbi Isolated osteoclast cultures
    Astrid Hoebertz
    Department of Anatomy and Developmental Biology, University College London, London, UK
    Methods Mol Med 80:53-64. 2003
  2. ncbi Regulation of bone cell function by acid-base balance
    Tim Arnett
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Proc Nutr Soc 62:511-20. 2003
    ..The present results suggest that even subtle chronic acidosis could be sufficient to cause appreciable bone loss over time...
  3. ncbi Extracellular pH regulates bone cell function
    Timothy R Arnett
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    J Nutr 138:415S-418S. 2008
    ..Diets or drugs that shift acid-base balance in the alkaline direction may provide useful treatments for bone loss disorders...
  4. ncbi Hypoxia is a major stimulator of osteoclast formation and bone resorption
    Timothy R Arnett
    Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
    J Cell Physiol 196:2-8. 2003
    ..These findings may help explain the bone loss associated with a wide range of pathological states involving local or systemic hypoxia, and emphasize the importance of the vasculature in bone...
  5. ncbi Acidosis, hypoxia and bone
    Timothy R Arnett
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Arch Biochem Biophys 503:103-9. 2010
    ..These observations may contribute to our understanding of the bone disturbances that occur in numerous settings, including ageing, inflammation, fractures, tumours, anaemias, kidney disease, diabetes, respiratory disease and smoking...
  6. ncbi Hypoxia stimulates vesicular ATP release from rat osteoblasts
    Isabel R Orriss
    Department of Cell and Developmental Biology, University College London, London, UK
    J Cell Physiol 220:155-62. 2009
    ..Moreover, increased extracellular ATP levels following acute exposure to low O(2) could influence local purinergic signaling and affect the balance between bone formation and bone resorption...
  7. ncbi Osteoblast responses to nucleotides increase during differentiation
    Isabel R Orriss
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Bone 39:300-9. 2006
    ..Taken together, these data suggest that the P2Y(2) receptor, and possibly the P2Y(4) receptor, could function as 'off-switches' for mineralized bone formation...
  8. ncbi Purinergic signalling and bone remodelling
    Isabel R Orriss
    Department of Cell and Developmental Biology, University College London, London, UK
    Curr Opin Pharmacol 10:322-30. 2010
    ..This review discusses the current understanding of the effects of extracellular nucleotides on skeletal cells...
  9. ncbi Inhibition of osteoblast function in vitro by aminobisphosphonates
    Isabel R Orriss
    Department of Cell and Developmental Biology, University College London, London, UK
    J Cell Biochem 106:109-18. 2009
    ..Although no data are available on the bisphosphonate concentrations that osteoblasts could be exposed to in vivo, our results are consistent with earlier observations that bisphosphonates may inhibit bone formation...
  10. ncbi Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate
    Isabel R Orriss
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    Endocrinology 148:4208-16. 2007
    ..Thus, a component of the profound inhibitory action of ATP and UTP on bone mineralization could be mediated directly by PPi, independently of P2 receptors...
  11. ncbi Hypoxia stimulates osteoclast formation from human peripheral blood
    Jennifer C Utting
    Department of Cell and Developmental Biology, University College London, London, UK
    Cell Biochem Funct 28:374-80. 2010
    ....
  12. ncbi The P2Y(6) receptor stimulates bone resorption by osteoclasts
    Isabel R Orriss
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    Endocrinology 152:3706-16. 2011
    ..Taken together these results show the P2Y(6) receptor may play an important role in the regulation of bone cell function in vivo...
  13. ncbi The in vitro effect of pH on osteoclasts and bone resorption in the cat: implications for the pathogenesis of FORL
    Mariusz Muzylak
    Department of Veterinary Basic Sciences, The Royal Veterinary College, London, UK
    J Cell Physiol 213:144-50. 2007
    ..These results demonstrate that acidosis is a major regulator of osteoclast formation and functional activation in the cat, and suggest that local pH changes may play a significant role in the pathogenesis of FORL...
  14. ncbi Rat osteoblast cultures
    Isabel R Orriss
    Department of Cell and Developmental Biology, University College London, London, UK
    Methods Mol Biol 816:31-41. 2012
    ..A special focus of this chapter is on the role of ?-glycerophosphate in cell-mediated mineralisation in these cultures...
  15. ncbi ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling
    Astrid Hoebertz
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Cell Biochem 86:413-9. 2002
    ..These findings suggest that extracellular nucleotides could function locally as important negative modulators of bone metabolism, perhaps contributing to bone loss in a number of pathological states...
  16. ncbi Rodent osteoclast cultures
    Isabel R Orriss
    Department of Cell and Developmental Biology, University College London, London, UK
    Methods Mol Biol 816:103-17. 2012
    ..A special focus will be on the role of extracellular pH, a critical factor in the control of osteoclast function...
  17. ncbi Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro
    Gary J Spencer
    Biomedical Tissue Research, Department of Biology, University of York, PO Box 373, York, YO10 5YW, UK
    J Cell Sci 119:1283-96. 2006
    ....
  18. ncbi Regulation of bone resorption and formation by purines and pyrimidines
    Astrid Hoebertz
    Research Institute of Molecular Biology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Trends Pharmacol Sci 24:290-7. 2003
    ..In this review, the current understanding of the actions of nucleotides on skeletal cells and the probable receptor subtypes involved are discussed...