Daniel James Antoine

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science
    Daniel J Antoine
    University of Liverpool, MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, L69 3GE, UK
    Expert Opin Drug Metab Toxicol 4:1415-27. 2008
  2. ncbi Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity
    Daniel James Antoine
    Medical Research Council Centre for Drug Safety Science Department of Pharmacology and Therapeutics, Institute for Translational Medicine, University of Liverpool, Liverpool, UK
    Mol Med 16:479-90. 2010
  3. ncbi Mechanism-based bioanalysis and biomarkers for hepatic chemical stress
    D J Antoine
    Department of Pharmacology and Therapeutics, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK
    Xenobiotica 39:565-77. 2009
  4. ncbi Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells
    Daniel J Antoine
    MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Merseyside, L69 3GE, UK
    Biochem Pharmacol 79:647-54. 2010
  5. ncbi High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo
    Daniel J Antoine
    MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L693GE, UK
    Toxicol Sci 112:521-31. 2009

Detail Information

Publications5

  1. ncbi Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science
    Daniel J Antoine
    University of Liverpool, MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, L69 3GE, UK
    Expert Opin Drug Metab Toxicol 4:1415-27. 2008
    ..Some of the steps being made to generate improved physiological systems to identify more sensitive, reflective mechanism-based biomarkers to aid the earlier identification of DILI and develop safer medicines are also discussed...
  2. ncbi Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity
    Daniel James Antoine
    Medical Research Council Centre for Drug Safety Science Department of Pharmacology and Therapeutics, Institute for Translational Medicine, University of Liverpool, Liverpool, UK
    Mol Med 16:479-90. 2010
    ..Thus, the inhibition of caspase-driven apoptosis and HMGB1 oxidation by ATP depletion from fasting promotes an inflammatory response during drug-induced hepatotoxicity/liver pathology...
  3. ncbi Mechanism-based bioanalysis and biomarkers for hepatic chemical stress
    D J Antoine
    Department of Pharmacology and Therapeutics, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK
    Xenobiotica 39:565-77. 2009
    ..These biomarkers can provide both the means to inform the pharmacologist and chemist with respect to safe drug design, and provide clinicians with valuable tools for patient monitoring...
  4. ncbi Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells
    Daniel J Antoine
    MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Merseyside, L69 3GE, UK
    Biochem Pharmacol 79:647-54. 2010
    ..In summary, our data suggest that the inhibition of the mevalonate pathway by statins may provide a potential therapeutic strategy to prevent AG-induced nephrotoxicity...
  5. ncbi High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo
    Daniel J Antoine
    MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L693GE, UK
    Toxicol Sci 112:521-31. 2009
    ..Based on these findings, potential exists for the qualification and measurement of these proteins to further assist in vitro, in vivo, and clinical bridging in toxicological research...