Judith C W Marsh

Summary

Affiliation: St George's Hospital Medical School
Country: UK

Publications

  1. ncbi Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: a report from the European Blood and Marrow Transplant (EBMT) S
    J Marsh
    Department of Haematology, St George s Hospital Medical School, London, UK
    Blood 93:2191-5. 1999
  2. ncbi Management of acquired aplastic anaemia
    Judith C W Marsh
    Department of Haematology, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Blood Rev 19:143-51. 2005
  3. ncbi Insights into the autoimmune nature of aplastic anaemia
    Judith C W Marsh
    St George's Hospital Medical School, London SW17 ORE, UK
    Lancet 364:308-9. 2004
  4. ncbi Stem cells in paroxysmal nocturnal haemoglobinuria and aplastic anaemia: increasing evidence for overlap of haemopoietic defect
    J C W Marsh
    Department of Haematology, St George s Hospital Medical School, London, UK
    Transfus Med 13:377-86. 2003
  5. ncbi Epstein-Barr virus infections after allogeneic stem cell transplantation: a comparison between non-malignant and malignant hematological disorders
    Md Serajul Islam
    Department of Hematology, St George s Hospital, London, UK
    Hematology 15:344-50. 2010
  6. ncbi A third course of anti-thymocyte globulin in aplastic anaemia is only beneficial in previous responders
    Vikas Gupta
    Division of Haematology, Department of Cellular and Molecular Sciences, St George's Hospital and Medical School, London, UK
    Br J Haematol 129:110-7. 2005
  7. ncbi Early cytomegalovirus infections following allogeneic stem cell transplantation: a comparison between non-malignant and malignant haematological disorders
    Md Serajul Islam
    Department of Haematology, St George s Hospital, London, UK
    Hematology 15:4-10. 2010
  8. ncbi Clinical relevance of cytogenetic abnormalities at diagnosis of acquired aplastic anaemia in adults
    Vikas Gupta
    Department of Haematology, St George's Hospital, London, UK
    Br J Haematol 134:95-9. 2006
  9. ncbi Evaluation of the haemopoietic reservoir in de novo haemolytic paroxysmal nocturnal haemoglobinuria
    Modupe O Elebute
    Department of Haematology, St George s Hospital Medical School, London, UK
    Br J Haematol 123:552-60. 2003
  10. ncbi Hematopoietic growth factors in the treatment of acquired bone marrow failure states
    Judith C W Marsh
    Department of Haematology, St George s Hospital St George s, University of London, London, UK
    Semin Hematol 44:138-47. 2007

Collaborators

Detail Information

Publications27

  1. ncbi Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: a report from the European Blood and Marrow Transplant (EBMT) S
    J Marsh
    Department of Haematology, St George s Hospital Medical School, London, UK
    Blood 93:2191-5. 1999
    ..001). We conclude that the combination of ATG and CSA is superior to CSA alone in terms of the hematologic response, the quality of response, and early mortality, and a second course of immunosuppression is less frequently required...
  2. ncbi Management of acquired aplastic anaemia
    Judith C W Marsh
    Department of Haematology, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Blood Rev 19:143-51. 2005
    ..Difficulties remain for those patients who fail immunosuppressive therapy and in whom BMT is not possible, since alternative immunosuppressive agents have so far proven to be somewhat disappointing...
  3. ncbi Insights into the autoimmune nature of aplastic anaemia
    Judith C W Marsh
    St George's Hospital Medical School, London SW17 ORE, UK
    Lancet 364:308-9. 2004
  4. ncbi Stem cells in paroxysmal nocturnal haemoglobinuria and aplastic anaemia: increasing evidence for overlap of haemopoietic defect
    J C W Marsh
    Department of Haematology, St George s Hospital Medical School, London, UK
    Transfus Med 13:377-86. 2003
    ..This results in the selection of the PIG-deficient clone, in contrast to the PIG-normal stem cells which possess the PIG anchor and hence are targeted and depleted by the autoreactive T cells...
  5. ncbi Epstein-Barr virus infections after allogeneic stem cell transplantation: a comparison between non-malignant and malignant hematological disorders
    Md Serajul Islam
    Department of Hematology, St George s Hospital, London, UK
    Hematology 15:344-50. 2010
    ..Post-transplant EBV infections did not influence overall survival (non-malignant, P=0·66; malignant, P=0·41) in either of the subgroups. There were no deaths directly attributable to EBV infections...
  6. ncbi A third course of anti-thymocyte globulin in aplastic anaemia is only beneficial in previous responders
    Vikas Gupta
    Division of Haematology, Department of Cellular and Molecular Sciences, St George's Hospital and Medical School, London, UK
    Br J Haematol 129:110-7. 2005
    ..Patients refractory to previous two courses of ATG have a much lower response rate and may be suitable candidates for novel therapeutic options...
  7. ncbi Early cytomegalovirus infections following allogeneic stem cell transplantation: a comparison between non-malignant and malignant haematological disorders
    Md Serajul Islam
    Department of Haematology, St George s Hospital, London, UK
    Hematology 15:4-10. 2010
    ..022; odds ratio: 0.18) and recipient seropositivity in patients with malignancies (negative versus positive; P=0.001, odds ratio: 0.01) were identified to be significant factors for risk of CMV infection...
  8. ncbi Clinical relevance of cytogenetic abnormalities at diagnosis of acquired aplastic anaemia in adults
    Vikas Gupta
    Department of Haematology, St George's Hospital, London, UK
    Br J Haematol 134:95-9. 2006
    ..None of the patients with a non-numerical karyotypic abnormality responded. No significant differences in survival or later clonal disorders were observed between patients with a normal karyotype and those with an abnormal karyotype...
  9. ncbi Evaluation of the haemopoietic reservoir in de novo haemolytic paroxysmal nocturnal haemoglobinuria
    Modupe O Elebute
    Department of Haematology, St George s Hospital Medical School, London, UK
    Br J Haematol 123:552-60. 2003
    ....
  10. ncbi Hematopoietic growth factors in the treatment of acquired bone marrow failure states
    Judith C W Marsh
    Department of Haematology, St George s Hospital St George s, University of London, London, UK
    Semin Hematol 44:138-47. 2007
    ..G-CSF is used in supportive care of MDS to improve neutropenia during infectious complications, but to date there is no compelling evidence for a survival benefit or alteration of the course of the disease through the use of HGFs in MDS...
  11. ncbi The spectrum of PIG-A gene mutations in aplastic anemia/paroxysmal nocturnal hemoglobinuria (AA/PNH): a high incidence of multiple mutations and evidence of a mutational hot spot
    Yousef Mortazavi
    Department of Haematology, St George s Hospital Medical School, London, United Kingdom
    Blood 101:2833-41. 2003
    ..Our results suggest that the large majority of AA/PNH patients have multiple mutations. These data may suggest a process of hypermutation in the PIG-A gene in AA stem cells...
  12. ncbi A pilot study of antithymocyte globulin (ATG) in the treatment of patients with 'low-risk' myelodysplasia
    Sally B Killick
    Department of Haematology, St George s Hospital, London, UK
    Br J Haematol 120:679-84. 2003
    ..The median duration of response was 15.5 months (2-42+ months) at the time of analysis...
  13. ncbi Favorable effect on acute and chronic graft-versus-host disease with cyclophosphamide and in vivo anti-CD52 monoclonal antibodies for marrow transplantation from HLA-identical sibling donors for acquired aplastic anemia
    Vikas Gupta
    Department of Cellular and Molecular Sciences, Division of Haematology, St George s Hospital and Medical School, London, UK
    Biol Blood Marrow Transplant 10:867-76. 2004
    ..The favorable effect on the incidence and severity of GVHD is noteworthy in this study and warrants further investigation...
  14. ncbi Bone marrow failure syndromes
    Judith C W Marsh
    Division of Cellular and Molecular Medicine, St George's University of London, Department of Haematology, St George's Hospital, London
    Clin Med 5:332-6. 2005
  15. ncbi Marrow transplants from matched unrelated donors for aplastic anaemia using alemtuzumab, fludarabine and cyclophosphamide based conditioning
    V Gupta
    Department of Cellular and Molecular Sciences, Division of Haematology, St George's Hospital and Medical School, London, UK
    Bone Marrow Transplant 35:467-71. 2005
    ....
  16. ncbi Autologous recovery following non-myeloablative unrelated donor bone marrow transplantation for severe aplastic anaemia
    M O Elebute
    Department of Haematology, St George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Ann Hematol 81:378-81. 2002
    ..This study also shows that autologous recovery with long-term survival can occur following non-irradiation conditioning regimens...
  17. ncbi Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia
    M S Islam
    Department of Haematology, St George s Hospital, Tooting, London, UK
    Bone Marrow Transplant 45:886-94. 2010
    ..0) and OS (P=0.57), were not significantly influenced by the CD34+ cell dose. These findings are different to the published studies on the relevance of CD34+ cell dose in allogeneic transplantation for haematological cancers...
  18. ncbi Low dose antithymocyte globulin for the treatment of older patients with aplastic anaemia
    S B Killick
    Department of Haematology, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK
    Leuk Res 30:1517-20. 2006
    ..Only one of the 12 evaluable patients responded to treatment and remains transfusion independent at 14 months after ATG. These results suggest that this lower dose of ATG, though well tolerated, had low efficacy in the treatment of AA...
  19. ncbi Aplastic anaemia in association with coeliac disease: a series of three cases
    E Grey-Davies
    Department of Haematology, St George s Hospital, London, UK
    Br J Haematol 143:258-60. 2008
    ..Immunosuppressive therapy for AA could modulate the course of celiac disease. We recommend clinicians should be vigilant for signs of coeliac disease in patients with AA...
  20. ncbi Guidelines for the diagnosis and management of acquired aplastic anaemia
    J C W Marsh
    St. George's Hospital Medical School, London, UK
    Br J Haematol 123:782-801. 2003
  21. ncbi Treatment of acquired aplastic anemia
    Judith C W Marsh
    Haematologica 92:2-5. 2007
  22. ncbi Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia
    Hubert Schrezenmeier
    Institute of Clinical Transfusion Medicine and Immunogenetics, University of Ulm, Germany
    Blood 110:1397-400. 2007
    ..Corresponding probabilities for older patients were 52% and 64%. These data indicate that BM grafts are preferred to PBPC grafts in young patients undergoing HLA-matched sibling donor transplantation for SAA...
  23. ncbi Role of nonmyeloablative allogeneic stem-cell transplantation after failure of autologous transplantation in patients with lymphoproliferative malignancies
    Katharine Branson
    CR (UK) Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom
    J Clin Oncol 20:4022-31. 2002
    ..The low incidence of early GVHD enabled the subsequent administration of DLI to improve further clinical responses in this poor-risk group of lymphoma and myeloma patients...
  24. ncbi Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria
    Peter Hillmen
    Department of Haematology, Leeds Teaching Hospitals National Health Science Trust, Leeds, United Kingdom
    N Engl J Med 350:552-9. 2004
    ..We tested the clinical efficacy of eculizumab, a humanized antibody that inhibits the activation of terminal complement components, in patients with PNH...
  25. ncbi Bone marrow stem cells and stromal cells in autoimmune cytopenias
    Helen A Papadaki
    Department of Haematology, University of Crete School of Medicine, University Hospital of Heraklion, Greece
    Leuk Lymphoma 43:753-60. 2002
    ..The underlying mechanisms possibly involved in the pathogenesis of the observed abnormalities are also discussed...
  26. ncbi Influence of donor/recipient sex matching on outcome of allogeneic hematopoietic stem cell transplantation for aplastic anemia
    Martin Stern
    University Hospital, Department of Hematology, Basel, Switzerland
    Transplantation 82:218-26. 2006
    ..Wherever possible, donor-recipient sex-matching should be integrated into donor selection algorithms...