Patricia S Fletcher

Summary

Affiliation: St George's
Country: UK

Publications

  1. ncbi Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants
    Patricia S Fletcher
    Centre for Infection, Department of Cellular and Molecular Medicine, St George s, University of London, London, UK
    Retrovirology 3:46. 2006
  2. ncbi Preclinical evaluation of lime juice as a topical microbicide candidate
    Patricia S Fletcher
    St George s University of London, UK
    Retrovirology 5:3. 2008
  3. ncbi PRO-2000, an antimicrobial gel for the potential prevention of HIV infection
    Patricia S Fletcher
    St George s University of London, Cranmer Terrace, London, SW17 0RE, UK
    Curr Opin Investig Drugs 9:189-200. 2008
  4. ncbi Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides
    Patricia S Fletcher
    St George's, University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    AIDS 20:1237-45. 2006
  5. ncbi In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories
    Brigitte E Beer
    Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA
    Antimicrob Agents Chemother 50:713-23. 2006

Detail Information

Publications5

  1. ncbi Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants
    Patricia S Fletcher
    Centre for Infection, Department of Cellular and Molecular Medicine, St George s, University of London, London, UK
    Retrovirology 3:46. 2006
    ..Here we have evaluated two candidate polyanion compounds in clinical trials, PRO 2000 and dextrin sulphate (DxS) to determine their safety and efficacy against in vitro HIV-1 and HSV-2 infection using cellular and tissue explant models...
  2. ncbi Preclinical evaluation of lime juice as a topical microbicide candidate
    Patricia S Fletcher
    St George s University of London, UK
    Retrovirology 5:3. 2008
    ..One suggested practice would be vaginal douching with natural products including lime or lemon juice. Here we present a comprehensive preclinical evaluation of lime juice (LiJ) as a potential intervention strategy against HIV...
  3. ncbi PRO-2000, an antimicrobial gel for the potential prevention of HIV infection
    Patricia S Fletcher
    St George s University of London, Cranmer Terrace, London, SW17 0RE, UK
    Curr Opin Investig Drugs 9:189-200. 2008
    ..A second phase III trial began for the prevention of sexually transmitted infections, including HIV, herpes, Chlamydia and gonorrhea, in Africa in October 2005...
  4. ncbi Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides
    Patricia S Fletcher
    St George's, University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
    AIDS 20:1237-45. 2006
    ..CONCLUSION: Colorectal explant culture was shown to be a useful tool for the preclinical evaluation of potential microbicides. The data suggest that rectally applied microbicides might provide protection from HIV-1 transmission...
  5. ncbi In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories
    Brigitte E Beer
    Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA
    Antimicrob Agents Chemother 50:713-23. 2006
    ..This comparative work can be used to develop standardized microbicide testing protocols that will help advance potential microbicides to clinical trials...