K W Colston

Summary

Affiliation: St George's Hospital Medical School
Country: UK

Publications

  1. ncbi Direct effects of bisphosphonates on breast cancer cells
    Siddhika G Senaratne
    Department of Oncology, Gastroenterology, Endocrinology, and Metabolism, St George's Hospital Medical School, Cranmer Terrace, London, UK
    Breast Cancer Res 4:18-23. 2002
  2. ncbi Mechanisms implicated in the growth regulatory effects of vitamin D in breast cancer
    K W Colston
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London SW17 0RE, UK
    Endocr Relat Cancer 9:45-59. 2002
  3. ncbi Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro
    K W Colston
    Division of Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London, UK
    Br J Cancer 76:1017-20. 1997
  4. ncbi Differential and antagonistic effects of 9-cis-retinoic acid and vitamin D analogues on pancreatic cancer cells in vitro
    F Pettersson
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London, UK
    Br J Cancer 83:239-45. 2000
  5. ncbi Bisphosphonates induce apoptosis in human breast cancer cell lines
    S G Senaratne
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London, UK
    Br J Cancer 82:1459-68. 2000
  6. ncbi Retinoic acid enhances the cytotoxic effects of gemcitabine and cisplatin in pancreatic adenocarcinoma cells
    F Pettersson
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George's Hospital Medical School, London, UK
    Pancreas 23:273-9. 2001
  7. ncbi Advances in the use of bisphosphonates in the prostate cancer setting
    J P Coxon
    Department of Urology, St George s Hospital, London, UK
    Prostate Cancer Prostatic Dis 7:99-104. 2004
  8. ncbi Interaction of vitamin D analogs with signaling pathways leading to active cell death in breast cancer cells
    G Pirianov
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George's Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Steroids 66:309-18. 2001
  9. ncbi The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells
    S G Senaratne
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Br J Cancer 86:1479-86. 2002
  10. ncbi A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer
    T Gulliford
    Cancer Research Campaign Laboratories, Department of Cancer Medicine, Imperial College School of Medicine, London, UK
    Br J Cancer 78:6-13. 1998

Collaborators

Detail Information

Publications17

  1. ncbi Direct effects of bisphosphonates on breast cancer cells
    Siddhika G Senaratne
    Department of Oncology, Gastroenterology, Endocrinology, and Metabolism, St George's Hospital Medical School, Cranmer Terrace, London, UK
    Breast Cancer Res 4:18-23. 2002
    ..These newly recognized direct actions of bisphosphonates on breast cancer cells indicate that these agents may have a greater role to play in treatment of patients suffering from cancers with a propensity to metastasize to bone...
  2. ncbi Mechanisms implicated in the growth regulatory effects of vitamin D in breast cancer
    K W Colston
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London SW17 0RE, UK
    Endocr Relat Cancer 9:45-59. 2002
    ....
  3. ncbi Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro
    K W Colston
    Division of Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London, UK
    Br J Cancer 76:1017-20. 1997
    ..p. thrice weekly for 4-6 weeks. Tumour growth was significantly inhibited in treated animals compared with controls in the absence of hypercalcaemia. These findings may have therapeutic implications in pancreatic cancer...
  4. ncbi Differential and antagonistic effects of 9-cis-retinoic acid and vitamin D analogues on pancreatic cancer cells in vitro
    F Pettersson
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London, UK
    Br J Cancer 83:239-45. 2000
    ..Our results show that retinoic acids as well as vitamin D analogues have inhibitory effects on pancreatic tumour cells but different and antagonistic mechanisms seem to be employed...
  5. ncbi Bisphosphonates induce apoptosis in human breast cancer cell lines
    S G Senaratne
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London, UK
    Br J Cancer 82:1459-68. 2000
    ....
  6. ncbi Retinoic acid enhances the cytotoxic effects of gemcitabine and cisplatin in pancreatic adenocarcinoma cells
    F Pettersson
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George's Hospital Medical School, London, UK
    Pancreas 23:273-9. 2001
    ..CONCLUSION: Our results clearly suggest the need for additional studies exploring the potential role of the combination of retinoids and gemcitabine in the management of pancreatic cancer...
  7. ncbi Advances in the use of bisphosphonates in the prostate cancer setting
    J P Coxon
    Department of Urology, St George s Hospital, London, UK
    Prostate Cancer Prostatic Dis 7:99-104. 2004
    ....
  8. ncbi Interaction of vitamin D analogs with signaling pathways leading to active cell death in breast cancer cells
    G Pirianov
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George's Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Steroids 66:309-18. 2001
    ....
  9. ncbi The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells
    S G Senaratne
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Br J Cancer 86:1479-86. 2002
    ..This process may be initiated by inhibition of the enzymes in the mevalonate pathway leading to impaired prenylation of key intracellular proteins including Ras...
  10. ncbi A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer
    T Gulliford
    Cancer Research Campaign Laboratories, Department of Cancer Medicine, Imperial College School of Medicine, London, UK
    Br J Cancer 78:6-13. 1998
    ..The dose estimated to be tolerable for most patients from this study is around 7 microg m(-2) day(1). These data support previous work that has demonstrated EB 1089 to be significantly less calcaemic than 1,25-dihydroxyvitamin D3...
  11. ncbi Involvement of stress activated protein kinases (JNK and p38) in 1,25 dihydroxyvitamin D3-induced breast cell death
    C M Brosseau
    Department of Cellular and Molecular Medicine, Division of Clinical Sciences, St George s University of London, London, UK
    Steroids 75:1082-8. 2010
    ..These results implicate JNK and p38 signalling in 1,25-D(3)-induced cancer breast cell death...
  12. ncbi The potential role of bisphosphonates in prostate cancer
    G M Oades
    Department of Urology, St George s Hospital and Medical School, London, UK
    Prostate Cancer Prostatic Dis 5:264-72. 2002
    ..Both preclinical and clinical evidence of a role for bisphosphonates in the treatment and prevention of bone metastases secondary to prostate cancer is assessed...
  13. ncbi Effects of Seocalcitol (EB1089) on nitrosomethyl urea-induced rat mammary tumors
    K W Colston
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London, UK
    Breast Cancer Res Treat 80:303-11. 2003
    ..However, reduction in tumor volume was maintained in the majority of animals...
  14. ncbi Vitamin D receptor-dependent antitumour effects of 1,25-dihydroxyvitamin D3 and two synthetic analogues in three in vivo models of prostate cancer
    G M Oades
    Department of Urology, St George s Hospital and Medical School, London, UK
    BJU Int 90:607-16. 2002
    ....
  15. ncbi Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax
    F Pettersson
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London SW17 ORE, UK
    Br J Cancer 87:555-61. 2002
    ..Our results encourage further work evaluating the clinical use of receptor subtype selective retinoids in pancreatic carcinoma...
  16. ncbi Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population
    D Bretherton-Watt
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London
    Br J Cancer 85:171-5. 2001
    ....
  17. ncbi A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer
    T R J Evans
    CRC Department of Medical Oncology, Beatson Oncology Centre, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
    Br J Cancer 86:680-5. 2002
    ..Further studies are necessary to determine if this agent has any cytostatic activity in this malignancy in minimal disease states...